Proprotein Convertase Subtilisin/kexin Type 6 (PCSK6) Antikörper

Antigen: Proprotein Convertase Subtilisin/kexin Type 6 (PCSK6)

Synonyme: SPC4, PACE4, Spc4, Pace4, PCSK6

Klonalität: Polyklonal

Wirt: Ziege

Applikation: ELISA

Produktnummer: ABIN308430

Produktbeschreibung

Weitere Bezeichnung: PCSK6

Gen-ID: 5046

Immunogen: C-YHTFSAHQSRSR

Format: Affinity-purified

Beschreibung: All names and symbols: PCSK6, proprotein convertase subtilisin/kexin type 6, PACE4, SPC4, paired basic amino acid cleaving system 4, subtilisin-like proprotein convertase 4, subtilisin-like protease, subtilisin/kexin-like protease PACE4. Official Symbol: PCSK6. RefSeq number(s): NP_002561.1, NP_612192.1, NP_612195.1, NP_612197.1, NP_612196.1, NP_612198.2, NP_612193.1, NP_612194.1

Spezifität: This antibody is expected to recognize reported isoforms a, b, g and h (NP_002561.1, NP_612192.1, NP_612193.1, NP_612194.1 resp.). Human

Anwendungen

Applikationshinweise: Peptide ELISA: antibody detection limit dilution 1:32,000. Western Blot: Preliminary experiments gave an approx 40-45 kDa band in Human Brain (Cerebellum) lysates after 0.2 µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 106 kDa according to NP_002561.1. The 40-45 kDa band was successfully blocked by incubation with the immunizing peptide. We would appreciate any feedback from people in the field - have any results been reported with other antibodies/lysates? Have any further splice variants/modified forms been reported?

Reinigung: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Buffer: Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Lagerung: Aliquot and store at -20°C. Minimize freezing and thawing.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Jin, Wang, Millar et al.: "Hepatic proprotein convertases modulate HDL metabolism." in: Cell metabolism, Vol. 6, Issue 2, pp. 129-36, 2007 (PubMed).