CYP3A5 Antikörper (C-Term)

Produktnummer ABIN307112

Der Maus Monoklonal anti-CYP3A5 Antikörper wird verwendet zum Nachweis von CYP3A5 in Proben von Human. Er wurde validiert für WB, IHC und ELISA.

Kurzübersicht für CYP3A5 Antikörper (C-Term) (ABIN307112)

Target: CYP3A5 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 (CYP3A5))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CYP3A5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Klon: F18 P3 B6

Produktdetails anti-CYP3A5 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Mouse anti Human Cytochrome P450 3A5

Kreuzreaktivität: Human

Produktmerkmale: CYP3A genes encode monooxygenases, enzymes which catalyze drug metabolism and the synthesis of cholesterol, steroids and other lipids. CYP3A (cytochrome P450, family 3, subfamily A), the most abundant p450 enzyme in human liver, is responsible for the metabolism of more than 50 % of all clinical drugs. CYP3A members localize in organs that associate with drug disposition, including the liver, gastrointestinal tract and kidney. The CYP3A cluster consists of four genes: CYP3A43, CYP3A4, CYP3A7 and CYP3A5, and two pseudogenes: CYP3A5P1 and CYP3A5P2. The CYP3A cluster maps to gene locus 7q21.3-q22.1.

Aufreinigung: Protein A/G Chromatography

Immunogen: Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with a synthetic peptide derived from the C-terminus of the human CYP3A5 protein and mouse myeloma Ag8563 cells.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Antibody can be used for Western blotting (1-2 μg/mL) and immunohistochemistry on formalin-fixed, paraffin-embedded tissues (1-5 μg/mL). When used in conjunction with CYP3A7 (Cat. No. X2048M), can differentiate between the CYP3A family members, 3A5 and 3A7. Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu CYP3A5

Target: CYP3A5 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 (CYP3A5))

Andere Bezeichnung: Cytochrome P450 3A5

Hintergrund: CYP3A5, CYP450 3A5 (EC 1.14.14.1), Niphedipine oxidase, CYPIIIA5, P450-PCN3, HLp2

UniProt: P20815

Pathways: Steroid Hormone Biosynthesis