Retinoblastoma-Like Protein 2 (RBL2) Antikörper

Antigen: Retinoblastoma-Like Protein 2 (RBL2)

Synonyme: Rb2, P130, FLJ26459, p130

Klonalität: Monoklonal (KAB40)

Wirt: Maus

Reaktivität: Human, Maus, Ratte (Rattus)

Applikation: Western Blot (WB)

Produktnummer: ABIN306630

Produktbeschreibung

Weitere Bezeichnung: p130

Swiss-Prot: Q08999

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: KAB40

Beschreibung: The immunogen used was a GST fusion protein to the N terminus of p130. p130 is related both in structure and function to the retinoblastoma tumor suppressor protein and p107(collectively known as pocket proteins) and are known to regulate the activity of E2F transcription factors. E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in the progression through G1 and into the S-phase of the cell cycle. Binding of p130 converts E2F transcription factors from transcriptional activators to transcriptional repressors. This antibody recognizes both the phosphorylated and unphosphorylated forms of p130 at a MW of 130kDa. Synonyms: p130, Retinoblastoma-like protein 2, RBR-2, PRB2.

Anwendungen

Lagerung: Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles

Beschränkungen: Nur für Forschungszwecke einsetzbar