SLIT1 Antikörper (AA 487-504)

Produktnummer ABIN303378

Der Kaninchen Polyklonal anti-SLIT1 Antikörper (ABIN303378) detektiert spezifisch SLIT1 in WB, IHC (p), IF und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Huhn und Frosch.

Kurzübersicht für SLIT1 Antikörper (AA 487-504) (ABIN303378)

Target: SLIT1 (Slit Homolog 1 (SLIT1))

Reaktivität: Human, Maus, Huhn, Frosch

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLIT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-SLIT1 Antikörper

Bindungsspezifität: AA 487-504

Spezifität: This antibody recognises Slit Homolog 1 (SLIT1).

Kreuzreaktivität (Details): Species reactivity (expected):Chicken, Frog.
Species reactivity (tested):Human and Mouse.

Aufreinigung: Immunoaffinity Chromatography.

Immunogen: Synthetic Peptide corresponding to aa 487-504 of Mouse SLIT-1 protein.

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on Paraffin Sections (5 μg/mL). Immunofluorescence. Western Blot (1/500-1/2000). ELISA (1/10000-1/50000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2 with 0.01 % (w/v) Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid cycles of freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. Dilute only prior to immediate use.

Details zu SLIT1

Target: SLIT1 (Slit Homolog 1 (SLIT1))

Andere Bezeichnung: SLIT1

Hintergrund: SLIT-1 (also known as KIAA0813, MEGF4, multiple epidermal growth factor-like domains 4 and Slit homolog 1 protein) is a Slit protein. This protein is a ligand for the Roundabout (Robo) receptors and acts as guidance cues in axonal migration/navigation during neural development, at the ventral midline of the neural tube. Slit1 and Slit2 are essential for midline guidance in the forebrain by acting as repulsive signals preventing inappropriate midline crossing by axons projecting from the olfactory bulb. Each SLIT gene encodes a putative secreted protein, which contains conserved protein-protein interaction domains including leucine-rich repeats and epidermal growth factor-like motifs, similar to those of the Drosophila protein. In situ hybridization studies indicated that the rat SLIT-1 mRNA was specifically expressed in the neurons of fetal and adult forebrains. This data suggests that the SLIT genes form an evolutionarily conserved group in vertebrates and invertebrates, and that the mammalian SLIT proteins may participate in the formation and maintenance of the nervous and endocrine systems by protein-protein interactions. Alternative splicing isoforms have been identified for Slit1 protein.Synonyms: KIAA0813, MEGF4, Multiple epidermal growth factor-like domains protein 4, SLIL1, SLIT-1, Slit homolog 1 protein

Gen-ID: 6585

NCBI Accession: NP_003052

UniProt: O75093

Pathways: Regulation of Cell Size