H/K/N-Ras Antikörper

Antigen: H/K/N-Ras

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Enzyme Immunoassay (EIA), Immunhistochemie (Paraffinschnitte) (IHC (p)), Western Blot (WB)

Produktnummer: ABIN271800

Produktbeschreibung

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Beschreibung: The KRAS gene encodes the human cellular homolog of a transforming gene isolated fromthe Kirsten rat sarcoma virus. The RAS proteins are GDP/GTP-binding proteins that act asintracellular signal transducers. The most well-studied members of the RAS (derived from'RAt Sarcoma' virus) gene family include KRAS, HRAS, and NRAS. These genes encodeimmunologically related proteins with a molecular mass of 21 kD and are homologs ofrodent sarcoma virus genes that have transforming abilities. While these wildtype cellularproteins in humans play a vital role in normal tissue signaling, including proliferation,differentiation, and senescence, mutated genes are potent oncogenes that play a role inmany human cancers.

Spezifität: RASH/RASK (H27) antibody detects endogenous levels of RASH/RASK protein. Species: Human, Mouse, Rat. Others not tested.

Anwendungen

Applikationshinweise: ELISA: 1: 20000~1: 40000. WB: 1: 500~1: 1000. IHC: 1: 50~1: 200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Konzentration: 1,0 mg/ml

Reinigung: Aff - Purified

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Lagerung: Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Beschränkungen: Nur für Forschungszwecke einsetzbar