HSV ICP27 Antikörper

Antigen: HSV ICP27

Klonalität: Monoklonal (H1113)

Wirt: Maus

Applikation: Western Blot (WB), Immunfluoreszenz (IF)

Produktnummer: ABIN265583

Produktbeschreibung

Produktmerkmale: Mouse monoclonal antibody to ICP27 of Herpes Simplex Virus. This antibody originates from ascites fluids and is purified by protein G agarose affinity chromatography.

Format: Affinity-purified

Isotyp: IgG1 kappa  (Passende Sekundärantikörper)

Klon: H1113

Beschreibung: Herpes simplex virus (HSV) ICP27 (Infected cell polypeptide 27) is an essential and multifunctional regulator of viral gene expression that modulates RNA splicing,polyadenylation, and nuclear export. ICP27 Belongs to the herpes viruses UL69 family. It is involved in the down-regulation of viral immediate-early genes and acts incombination with ICP0 and ICP4 as an activator of late genes. Alternate Names: anti-Herpes simplex virus 1 ICP27 antibody, anti-Herpes simplex virus 1 transcriptional regulator IE63 antibody, anti-Herpes simplex virus 2 ICP27 antibody, anti-Herpessimplex virus 2 transcriptional regulator IE63 antibody

Anwendungen

Applikationshinweise: Reactive with ICP27 of Herpes Simplex Virus in immunofluorescence (IFA) and western blot at 10 ug/ml.

Konzentration: 1.0 mg/ml

Reinigung: Protein G agarose affinity chromatography

Buffer: Phosphate Buffered Saline pH 7.4 (no azide)

Lagerung: This product is supplied frozen on dry ice. Upon receipt, store at -20°C. Avoid multiple freeze-thaw cycles as product degradation may result.

Forschungsgebiet: Virologie

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Salaun, MacDonald, Larralde et al.: "Poly(A)-binding protein 1 partially relocalizes to the nucleus during herpes simplex virus type 1 infection in an ICP27-independent manner and does not inhibit virus replication." in: Journal of virology, Vol. 84, Issue 17, pp. 8539-48, 2010 (PubMed).

Jin, Yan, Ma et al.: "An Herpesvirus Virulence Factor Inhibits Dendritic Cell Maturation Through Protein Phosphatase 1 and I{kappa}B Kinase." in: Journal of virology, 2011 (PubMed).

Luganini, Nicoletto, Pizzuto et al.: "Inhibition of herpes simplex virus type 1 and type 2 infections by peptide-derivatized dendrimers." in: Antimicrobial agents and chemotherapy, Vol. 55, Issue 7, pp. 3231-9, 2011 (PubMed). (1:200).

Malik, Tabarraei, Kehlenbach et al.: "Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through NUP62, inhibiting host nucleocytoplasmic transport pathways." in: The Journal of biological chemistry, 2012 (PubMed). (1:2000).