1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (Lysophosphatidic Acid Acyltransferase, Beta) (AGPAT2) Antikörper

Antigen: 1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (Lysophosphatidic Acid Acyltransferase, Beta) (AGPAT2)

Synonyme: BSCL, BSCL1, LPAAB, 1-AGPAT2, LPAAT-beta, AV000834, 2510002J07Rik, AGPAT2, MGC138073, zgc:153984

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Enzyme Immunoassay (EIA), Western Blot (WB)

Produktnummer: ABIN265083

Produktbeschreibung

Produktmerkmale: Synonyms: 1-AGP acyltransferase 2, LPAAT-beta, 1-acyl-sn-glycerol-3-phosphate acyltransferase beta,Lysophosphatidic acid acyltransferase beta, 1-acylglycerol-3-phosphate O-acyltransferase2

Weitere Bezeichnung: AGPAT2

Swiss-Prot: O15120

Immunogen: Synthetic peptide derived from the LPAAT-beta protein.

Kreuzreaktivität: Human

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Lysophospholipid Acyltransferases (LPLATs) catalyse the addition of fatty acyl moieties tothe glycerol backbone of lysophospholipids . In addition to playing a crutial role in thesynthesis of structural membrane components the LPLATs are also implicated in cellularsignalling responses for cytokines, growth factors and other agonists. Cellular signallingthrough the interleukin 1 receptor in human mesangial cells and EL-4 cells proceeds by theactivation of lysophosphatidic acid acyltransferase (LPAAT). Activation of LPAAT byinterleukin 1 results in the generation of unsaturated phosphatidic acid species, that arecrucial to the generation of diacylglycerol and interleukin 1 signalling. LPLATs are alsoinvolved in signalling for increased interleukin 2 synthesis through the T cell antigenreceptor. Activation of T-cells via anti-CD3 stimulation has been shown to increaseincorporation of polyunsaturated fatty acids into phosphatidylcholine vialysophosphatidylcholine acyltransferase. Activation of this enzyme is essential for thesustained activation and translocation of protein kinase C.

Spezifität: This antibody detects Lysophosphatidic Acid Acetyltransferase beta. Species: Human. Others not tested.

Anwendungen

Applikationshinweise: Western Blot: 5-10 µg/ml. Enzyme Immunoassay. Positive Control: Human Brain Lysate. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Konzentration: Lot specific

Reinigung: Purified

Buffer: Phosphate buffered saline with 0.08% Sodium Azide as preservative.

Lagerung: Ship on dry ice. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Beschränkungen: Nur für Forschungszwecke einsetzbar