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Antikörper
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anti-P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) Antikörper
P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) Antikörper
| Antigen |
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| Synonyme |
CD62, GRMP, PSEL, CD62P, GMP140, LECAM3, PADGEM, FLJ45155, Grmp, MGC129336, MGC129337, P-selectin, PSELECT, MGC124632, SELP |
| Klonalität |
Monoklonal (HI62P) |
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Wirt
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Reaktivität
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Human (55), Ratte (Rattus) (10), Ziege (9), Schaf (9), Affe (8), Maus (5), Katze (4), Rind (Kuh) (4), Pferd (4), Schwein (3), Primate (2), Barley (Hordeum vulgare) (1), Barnyard Grass (Echinochloa crus-galli) (1), Beet (Beta vulgaris) (1), Cotton (Gossypium hirsutum) (1), Fruchtfliege (Drosophila melanogaster) (1), Mung bean (Vigna radiata) (1), Sorghum (1), Hefe (Saccharomyces Cerevisiae) (1)
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Applikation
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| Produktnummer |
ABIN238417 |
| Menge |
0.1 mg (1.0 mg/ml) |
| Preis |
190,00 € Zzgl. Versandkosten €20,00 und MWSt
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| Lieferung nach |
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| Verfügbarkeit |
Lieferung in 7 bis 10 Werktagen |
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Produktmerkmale
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Synonyms: SELP, GMRP, GRMP, PADGEM, GMP-140, LECAM3, Granule membrane protein 140,Leukocyte-endothelial cell adhesion molecule 3, CD62 antigen-like family member P
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Weitere Bezeichnung
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CD62P / P-Selectin
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Swiss-Prot
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P16109
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Immunogen
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Human platelets.
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Kreuzreaktivität
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Human
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Isotyp
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IgG1
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Klon
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HI62P
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Beschreibung
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CD62P (P-selectin) is an adhesion glycoprotein that is expressed on platelets andendothelial cells upon their activation. Interaction between CD62P and its mucin-likeligand PSGL-1 (P-selectin glycoprotein ligand-1) expressed on the microvilli of mostleukocytes supports leukocyte rolling along postkapillary venules at the earliest time ofinflammation. Both CD62P and PSGL-1 are extended glycoproteins that form homodimers. CD62P dimerization is probably mediated through interactions of the transmembranedomains and stabilizes leukocyte tethering and rolling, probably by increasing rebindingwithin a bond cluster.
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Spezifität
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The antibody HI62P recognizes CD62P (P-selectin), a 140 kD single chain type Itransmembrane glycoprotein present in secretory α-granules in platelets, in Weibel-Paladebodies in endothelial cells and in megakaryocytes, it is relocated to the plasma membraneupon activation. Species: Human. Others not tested.
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Applikationshinweise
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Flow Cytometry. Western Blotting. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
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Konzentration
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1.0 mg/ml
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Reinigung
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Aff - Purified
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Buffer
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PBS, pH 7.4 with 15 mM sodium azide as preservative.
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Lagerung
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Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
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Beschränkungen
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Nur für Forschungszwecke einsetzbar
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Alternativen zu Antigen "P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP)", Typ "Antikörper" finden
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Wirte
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Maus (54), Kaninchen (2), Huhn (1)
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Reaktivitäten
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Human (55), Ratte (Rattus) (10), Ziege (9), Schaf (9), Affe (8), Maus (5), Katze (4), Rind (Kuh) (4), Pferd (4), Schwein (3), Primate (2), Barley (Hordeum vulgare) (1), Barnyard Grass (Echinochloa crus-galli) (1), Beet (Beta vulgaris) (1), Cotton (Gossypium hirsutum) (1), Fruchtfliege (Drosophila melanogaster) (1), Mung bean (Vigna radiata) (1), Sorghum (1), Hefe (Saccharomyces Cerevisiae) (1)
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Applikationen
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Durchflusszytometrie (FACS) (51), Western Blot (WB) (18), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (16), Immunpräzipitation (IP) (10), Immunhistochemie (Paraffinschnitte) (IHC (p)) (6), Immunfluoreszenz (IF) (4), ELISA (Detektionsantikörper) (3), Blockierende Antikörper (Inhibition) (2), Funktionale Studien (Func) (2), Immunolokalisation (IL) (1)
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Konjugate
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PE (13), FITC (6), APC (2), Biotin (2), Alexa Fluor 647 (1), PE,Cy5 (1), PE,DY647 (1)
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Alternativen 
