CD1a Molecule (CD1A) Antikörper (PE)

Antigen: CD1a Molecule (CD1A)

Synonyme: R4, T6, CD1, FCB6, HTA1, CD1A, CD1.1, CD1.2, CD1A2

Klonalität: Monoklonal (HI149)

Wirt: Maus

Reaktivität: Human

Konjugat: PE

Applikation: Durchflusszytometrie (FACS)

Produktnummer: ABIN238416

Produktbeschreibung

Weitere Bezeichnung: CD1a

Swiss-Prot: P06126

Immunogen: Human thymocytes.

Kreuzreaktivität: Human

Isotyp: IgG1

Klon: HI149

Beschreibung: CD1a, together with CD1b and c, belongs to group 1 of CD1 glycoproteins. These proteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent upon vesicular acidification.

Spezifität: The antibody HI149 reacts with CD1a (T6), a 49 KDa polypeptide associated with b 2- microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells and some T cell leukemias and lymphomas. The antibody does not react with peripheral blood T and B lymphocytes, monocytes, granulocytes, platelets and erythrocytes.

Anwendungen

Applikationshinweise: Suitable for Flow Cytometry analysis of human blood cells using 20 m l reagent / 100 m l of whole blood or 10e6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Buffer: PBS containing 15 mM sodium azide as preservative and 0.2% (w/v) high-grade BSA (Protease free) as stabilizer.

Lagerung: Store the antibody in the dark at 2-8°C. Do Not Freeze! Avoid prolonged exposure to light. Shelf Life: one year from despatch.

Forschungsgebiet: Immunologie, Adaptive Immunität, CD Antigene, Oberflächenrezeptoren der Immunzellen

Beschränkungen: Nur für Forschungszwecke einsetzbar