»
Antikörper
»
anti-Death-Domain Associated Protein (DAXX) Antikörper
Death-Domain Associated Protein (DAXX) Antikörper
| Antigen |
|
| Synonyme |
DAP6, EAP1, BING2, MGC126245, MGC126246, MGC150289, DAP-3, 4921514D13Rik, im:6905684, LOC100226911 |
| Klonalität |
Monoklonal (DAXX-03) |
|
Wirt
|
|
|
Reaktivität
|
|
|
Applikation
|
 Alternativen Immunfluoreszenz (IF), Immunpräzipitation (IP), Western Blot (WB)
Western Blot (WB) (64), Immunfluoreszenz (IF) (36), Durchflusszytometrie (FACS) (23), Immunhistochemie (Paraffinschnitte) (IHC (p)) (17), ELISA (16), Enzyme Immunoassay (EIA) (15), Immunzytochemie (ICC) (9), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (8), Immunpräzipitation (IP) (8), Immunhistochemie (IHC) (7), Dot Blot (Dot) (4), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (2), ELISA (Detektionsantikörper) (1), Immunoelectron Microscopy (IEM) (1)
|
| Produktnummer |
ABIN238399 |
| Menge |
0.1 mg (1.0 mg/ml) |
| Preis |
200,00 € Zzgl. Versandkosten €20,00 und MWSt
|
| Lieferung nach |
|
| Verfügbarkeit |
Lieferung in 7 bis 10 Werktagen |
|
Produktmerkmale
|
Synonyms: BING2, DAP6, EAP1, Death domain-associated protein 6, Fas death domain-associatedprotein, ETS1-associated protein 1
|
|
Weitere Bezeichnung
|
DAXX
|
|
Swiss-Prot
|
Q9UER7
|
|
Immunogen
|
His6-tagged protein corresponding to amino acids 580-740 of human Daxx.
|
|
Kreuzreaktivität
|
Human
|
|
Isotyp
|
IgG1 (Passende Sekundärantikörper)
|
|
Klon
|
DAXX-03
|
|
Beschreibung
|
Daxx is an apoptosis-modulating death-domain associated protein with functions intranscriptional regulation. Daxx functions bot in cytoplasm, where it interacts with Fas, andin nucleus (residing in PML oncogenic domains), where it is involved in SUMO-dependentregulation of transcription and subnuclear compartmentalization. Daxx senzitizes the cellsto apoptosis, but on the other hand, this protein may also serve in preventing apoptosis inthe early embryo. Even regarding the transcription, Daxx can serve both as a corepressorand a coactivator. During ischemic stress, Daxx translocates from the nucleus to thecytoplasm, where in regulates sodium hydrogen exchanger isoform 1 (NHE1).
|
|
Spezifität
|
The antibody DAXX-03 reacts with C-terminal part of Daxx, a 110 kDa intracellular protein. Species: Human. Others not tested.
|
|
Applikationshinweise
|
Immunoprecipitation. Western Blotting (2 μg/ml. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
|
|
Konzentration
|
1.0 mg/ml
|
|
Reinigung
|
Aff - Purified
|
|
Buffer
|
PBS, pH 7.4 with 15 mM sodium azide as preservative.
|
|
Lagerung
|
Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid freeze/thaw cycles. Shelf life: One year from despatch.
|
|
Beschränkungen
|
Nur für Forschungszwecke einsetzbar
|
Alternativen zu Antigen "Death-Domain Associated Protein (DAXX)", Typ "Antikörper" finden
|
Wirte
|
Kaninchen (64), Maus (22)
|
|
Reaktivitäten
|
Human (84), Maus (38), Ratte (Rattus) (30), Rind (Kuh) (19), Hund (16), Schwein (16), Kaninchen (16), Schaf (15), Affe (7), Pferd (1)
|
|
Applikationen
|
Western Blot (WB) (64), Immunfluoreszenz (IF) (36), Durchflusszytometrie (FACS) (23), Immunhistochemie (Paraffinschnitte) (IHC (p)) (17), ELISA (16), Enzyme Immunoassay (EIA) (15), Immunzytochemie (ICC) (9), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (8), Immunpräzipitation (IP) (8), Immunhistochemie (IHC) (7), Dot Blot (Dot) (4), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (2), ELISA (Detektionsantikörper) (1), Immunoelectron Microscopy (IEM) (1)
|
|
Konjugate
|
Alexa Fluor 488 (2), Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
|
|
Epitope
|
C-Term (7), S495 (2), pSer213 (2), pSer495 (2), pSer517 (2), pSer671 (2), AA 272-291 (1), AA 561- 661 (1), S213 (1), S517 (1), pS671 (1)
|
