APP Antikörper (C-Term)

Produktnummer ABIN205860

Der Kaninchen Polyklonal anti-APP Antikörper (ABIN205860) detektiert spezifisch APP in WB, IHC und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für APP Antikörper (C-Term) (ABIN205860)

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-APP Antikörper

Bindungsspezifität: AA 737-751, C-Term

Spezifität: Recognizes both intact Amyloid Precursor Protein (APP), and also the C99 fragment generated by Beta-secretase. The sequence recognized by this corresponds to amino acids 85-99 of the C99 fragment. The C99 fragment itself is a substrate for gamma-secretase to generate the 4 kD beta amyloid peptide, found in the brains of Alzheimer's disease patients. APP also inhibits Notch signaling through it's interaction with NUMB. Has been used successfully for the detection of the ~14 kD beta C-terminal fragment of APP, produced as a result of cleavage by BACE1 using western blotting -in rat retinal lysates.

Aufreinigung: Purified

Immunogen: Synthetic peptide corresponding to amino acids 737-751 of human APP ( C-TERMINAL ).

Type of Immunogen: Synthetic peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Approved: IHC, IHC-P, WB (1:500 - 1:1000)

Usage: Immunohistology: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS,  pH 7.4, 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Details zu APP

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Andere Bezeichnung: APP / beta Amyloid

Hintergrund: Name/Gene ID: APP
Family: Amyloid precursor protein

Synonyms: APP, ABPP, A4, ABETA, AD1, Alzheimer disease, Amyloid beta, Beta-amyloid peptide, APPI, Beta amyloid, CVAP, AAA, PN2, PreA4, Amyloid beta A4 protein, Peptidase nexin-II, CTFgamma, PN-II, Protease nexin-II

Gen-ID: 351

UniProt: P05067

Pathways: Caspase Kaskade in der Apoptose, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour