CCL5 Antikörper

Produktnummer ABIN205820

Der Kaninchen Polyklonal anti-CCL5 Antikörper wird verwendet zum Nachweis von CCL5 in Proben von Human. Er wurde validiert für WB, ELISA und Func.

Kurzübersicht für CCL5 Antikörper (ABIN205820)

Target: CCL5 (Chemokine (C-C Motif) Ligand 5 (CCL5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCL5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Functional Studies (Func)

Produktdetails anti-CCL5 Antikörper

Spezifität: Recognizes human RANTES (regulated upon activation, normal T cell expressed and secreted), otherwise known as CCL5, a 68 amino acid CC- chemokine involved in T cell activation and cell recruitment, expressed by cytotoxic (CD8+) T cells (CTLs), macrophages, keratinocytes and endothelial cells. RANTES acts as a chemoattractant for monocytes, CD4+/CD45RO+ memory T cells, basophils and eosinophils, thorough binding to chemokine (C-C motif) receptor 1 (CCR1), CCR3 and CCR5. Both CCR3 and CCR5 are known co-receptors for the entry of HIV viruses into target cells and the binding of RANTES to CCR3 on CTLs has been shown to enhance HIV-1-specific cytotoxicity, whilst binding to CCR5 inhibits membrane fusion and hence HIV entry.

Aufreinigung: Purified

Immunogen: Recombinant human RANTES.

Type of Immunogen: Recombinant protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Approved: ELISA (0.5 - 2 μg/mL), Func (5 - 7 μg/mL), WB (0.1 - 0.2 μg/mL)

Usage: ELISA: May be used in an indirect ELISA or as a capture reagent in a sandwich ELISA. Western Blot: May be used in either reducing or non-reducing conditions.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Distilled Water. For long term storage the addition of 0.09 % sodium azide is recommended. For functional studies do not add azide.

Konzentration: Lot specific

Buffer: Lyophilized, PBS,  pH 7.4.

Details zu CCL5

Target: CCL5 (Chemokine (C-C Motif) Ligand 5 (CCL5))

Andere Bezeichnung: CCL5 / RANTES

Hintergrund: Name/Gene ID: CCL5
Family: Intercrine

Synonyms: CCL5, Chemokine (C-C motif) ligand 5, D17S136E, EoCP, T-cell specific protein p288, SCYA5, SISd, T cell-specific protein P228, Beta-chemokine RANTES, C-C motif chemokine 5, RANTES, SIS-delta, Small-inducible cytokine A5, T-cell-specific protein RANTES, TCP228

Gen-ID: 6352

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of G-Protein Coupled Receptor Protein Signaling, Smooth Muscle Cell Migration