Substance P Antikörper
| Antigen |
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| Synonyme |
NK2, NPK, NKNA, TAC2, Hs.2563, SP, NK1, NK-1, Nkna, PPT-A, MGC151458, 4930528L02Rik |
| Klonalität |
Monoklonal (SP-DE4-21) |
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Wirt
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Reaktivität
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Human (39), Ratte (Rattus) (25), Maus (21), Rind (Kuh) (16), Meerschweinchen (16), Kaninchen (16), Pferd (15), Schaf (15), Säugetiere (2), Huhn (1), Fisch (1), Affe (1), Schwein (1)
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Applikation
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Alternativen Immunhistochemie (Gefrierschnitte) (IHC (fro)), Enzyme Immunoassay (EIA), Immunfluoreszenz (IF)
Immunfluoreszenz (IF) (31), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (20), Durchflusszytometrie (FACS) (19), Immunhistochemie (Paraffinschnitte) (IHC (p)) (17), ELISA (8), Immunhistochemie (IHC) (8), Western Blot (WB) (4), Enzyme Immunoassay (EIA) (3), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (2), Immunpräzipitation (IP) (2), Immunoelectron Microscopy (IEM) (1), Radioimmunoassay (RIA) (1)
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| Produktnummer |
ABIN192028 |
| Menge |
100 µg (Varianten) |
| Preis |
330,00 € Zzgl. Versandkosten €40,00 und MWSt
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| Lieferung nach |
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| Verfügbarkeit |
Lieferung in 7 bis 10 Werktagen |
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Produktmerkmale
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Synonyms: Substance-P
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Gen-ID
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6863
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Swiss-Prot
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P20366
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Immunogen
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Synthetic human Substance P. AA Sequence: R-P-R-P-Q-Q-F-F-G-L-M
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Kreuzreaktivität
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Meerschweinchen, Human, Maus, Ratte (Rattus)
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Isotyp
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IgG1 (Passende Sekundärantikörper)
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Klon
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SP-DE4-21
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Beschreibung
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Substance P (SP) is currently thought to be one of the most important neurotransmittersand neurotransmitters in the brain. It is an undecapeptide belonging to the tachykininfamily, which consists of excitatory neuropeptides synthesised in neuronal and glial cellsof the human central and peripheral nervous system. Substance P, Neurokinin A,Neuropeptide K, and Neuropeptide gamma are all generated by post-translation cleavageof the precursor Protachykinin-1. Substance P forms the major endogenous ligand forNeurokinin 1 Receptor. The pharmacology of Substance P has been associated with anumber of neurological and psychiatric disorders, namely nociception, migraine, asthma,nausea, inflammatory bowel syndrome, urinary incontinence, anxiety and depression. Ithas also been linked to obesity.
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Spezifität
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The antibody reacts specifically with Substance P. No cross reaction against related Tachykinins (Neurokinin A, Neurokinin B, and Kassinin). Species: Human. Others not tested. Add. Information: LocusID 6863 (tachykinin precursor contains: substance K, substance P, neurokinin 1,neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
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Applikationshinweise
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ELISA (1/10.000)Immunostaining (1/1000)Immunostaining of Rat Tissue (1/2000). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
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Reinigung
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Purified
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Buffer
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0.1 M Glycin PBS pH 7,4Reconstitution: Restore in aqua bidest to 1 mg/ml.
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Lagerung
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Store the antibody lyophilized at 2-8°C and reconstituted at -20°C. Avoid repeated freezing and thawing. Shelf life: One year from despatch.
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Forschungsgebiet
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Neurologie, Zell-/Gewebemarker
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Beschränkungen
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Nur für Forschungszwecke einsetzbar
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Alternativen zu Antigen "Substance P", Typ "Antikörper" finden
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Wirte
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Kaninchen (39), Maus (8), Meerschweinchen (4), Ratte (3)
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Reaktivitäten
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Human (39), Ratte (Rattus) (25), Maus (21), Rind (Kuh) (16), Meerschweinchen (16), Kaninchen (16), Pferd (15), Schaf (15), Säugetiere (2), Huhn (1), Fisch (1), Affe (1), Schwein (1)
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Applikationen
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Immunfluoreszenz (IF) (31), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (20), Durchflusszytometrie (FACS) (19), Immunhistochemie (Paraffinschnitte) (IHC (p)) (17), ELISA (8), Immunhistochemie (IHC) (8), Western Blot (WB) (4), Enzyme Immunoassay (EIA) (3), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (2), Immunpräzipitation (IP) (2), Immunoelectron Microscopy (IEM) (1), Radioimmunoassay (RIA) (1)
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Konjugate
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Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
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Epitope
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AA 4-11 (2)
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