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EGFR Antikörper (pTyr998)

Name: EGFR Antikörper (pTyr998)
SKU: ABIN1881284
Price: 467.5 EUR
Availability: InStock

EGFR Reaktivität: Human WB, DB Wirt: Kaninchen Polyclonal RB11058 unconjugated

Western blot analysis of EGFR (arrow) in Hela cell lysates, either induced (Lane 1) or noninduced with EGF (Lane 2). (EGFR Antikörper (pTyr998))

Dot blot analysis of Phospho-EGFR- Antibody (ABIN1881284 and ABIN2850455) and EGFR Non Phospho-specific Pab on nitrocellulose membrane. (EGFR Antikörper (pTyr998))

2 Abbildungen

(5 Referenzen)

Produktnummer ABIN1881284

Datenblatt (PDF)

Target Alle EGFR Antikörper anzeigen

EGFR (Epidermal Growth Factor Receptor (EGFR))
Bindungsspezifität
39

38

31

31

30

28

26

26

25

22

21

18

16

16

16

15

15

15

11

11

10

9

9

9

8

8

7

6

5

5

5

4

4

4

4

4

4

4

4

3

3

3

3

3

3

3

3

3

3

3
pTyr998
Reaktivität
761

299

287

25

25

24

20

14

8

3

2

2

1

1

1

1

1

1
Human
Wirt
580

178

14

13

5

4

1

1
Kaninchen
Passende Sekundärantikörper
Klonalität
542

249

2
Polyklonal
Konjugat
415

58

29

22

20

18

18

17

16

16

16

12

10

10

10

10

10

10

10

10

10

8

8

5

4

4

4

4

4

2

1

1

1

1

1

1
Dieser EGFR Antikörper ist unkonjugiert
Applikation
537

252

154

151

128

102

99

93

82

46

36

34

34

19

11

8

6

5

4

4

3

3

3

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
Western Blotting (WB), Dot Blot (DB)

Homologie

M

Aufreinigung

This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen

This EGFR Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y998 of human EGFR.

Klon

RB11058

Isotyp

Ig Fraction

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EGFR Reaktivität: Human WB, IHC, IP, ICC Wirt: Maus Monoclonal C4 unconjugated

anti-Epidermal Growth Factor Receptor (EGFR) (AA 1163-1191), (C-Term) antibody
EGFR Reaktivität: Human WB, IHC (p) Wirt: Maus Monoclonal 688CT33-1-3 unconjugated

anti-Epidermal Growth Factor Receptor (EGFR) (C-Term) antibody
EGFR Reaktivität: Human, Maus, Ratte, Schwein, Affe, Rind (Kuh), Huhn, Hund, Pferd, Kaninchen, Meerschweinchen, Avian, Cat, Esel, Ziege, Hamster, Schaf WB Wirt: Ziege Polyclonal unconjugated

anti-Epidermal Growth Factor Receptor (EGFR) (AA 693-893) antibody
EGFR Reaktivität: Human WB, ELISA, FACS Wirt: Maus Monoclonal 5E10D3 unconjugated

anti-Epidermal Growth Factor Receptor (EGFR) (pSer1026) antibody
EGFR Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Epidermal Growth Factor Receptor (EGFR) (pSer1071) antibody
EGFR Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Epidermal Growth Factor Receptor (EGFR) (pSer695) antibody
EGFR Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Epidermal Growth Factor Receptor (EGFR) (AA 1021-1210) antibody
EGFR Reaktivität: Human WB, IF, IP Wirt: Kaninchen Polyclonal unconjugated

anti-Epidermal Growth Factor Receptor (EGFR) (C-Term) antibody
EGFR Reaktivität: Human, Ratte WB, ELISA, IHC, IP Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

WB: 1:1000. DB: 1:500

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Haltbarkeit

6 months
Aifa, Aydin, Nordvall, Lundström, Svensson, Hermanson: "A basic peptide within the juxtamembrane region is required for EGF receptor dimerization." in: Experimental cell research, Vol. 302, Issue 1, pp. 108-14, (2004) (PubMed).

Adams, McKern, Ward: "Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor." in: Growth factors (Chur, Switzerland), Vol. 22, Issue 2, pp. 89-95, (2004) (PubMed).

Ichinose, Murata, Yanagida, Sako: "EGF signalling amplification induced by dynamic clustering of EGFR." in: Biochemical and biophysical research communications, Vol. 324, Issue 3, pp. 1143-9, (2004) (PubMed).

Kuribayashi, Kataoka, Kurabayashi, Miura: "Evidence that basal activity, but not transactivation, of the epidermal growth factor receptor tyrosine kinase is required for insulin-like growth factor I-induced activation of extracellular signal-regulated kinase in oral carcinoma cells." in: Endocrinology, Vol. 145, Issue 11, pp. 4976-84, (2004) (PubMed).

Kapoor, Zhan, Johnson, ORourke: "Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells." in: Molecular and cellular biology, Vol. 24, Issue 2, pp. 823-36, (2003) (PubMed).
Target

EGFR (Epidermal Growth Factor Receptor (EGFR))

Andere Bezeichnung

EGFR (EGFR Produkte)

Hintergrund

Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR overexpression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma. EGFR is a receptor for EGF, but also for other members of the EGF family, including TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation.

Molekulargewicht

134277

NCBI Accession

NP_005219, NP_958439, NP_958440, NP_958441

UniProt

P00533

Pathways

NF-kappaB Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteine