P2RX7 Antikörper (N-Term)

Produktnummer ABIN183188

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-P2RX7 Antikörper wird verwendet zum Nachweis von P2RX7 in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Kaninchen und Meerschweinchen. Er wurde validiert für WB und IHC.

Kurzübersicht für P2RX7 Antikörper (N-Term) (ABIN183188)

Target: P2RX7 (Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser P2RX7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-P2RX7 Antikörper

Bindungsspezifität: N-Term

Sequenz: IQSMNYGTIK WFFHVIIFSY VCFALVSDKL YQRKEPVISS VHTKVKGIAE

Homologie: Cow: 93%, Dog: 79%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against P2RX7. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human P2RX7

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 595 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-P2RX7 Antikörper (ABIN183188)

Schneider, Glaser, Lameu, Abdelbaset-Ismail, Sellers, Moniuszko, Ulrich, Ratajczak: "Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells." in: Molecular cancer, Vol. 14, pp. 201, (2015) (PubMed).

Details zu P2RX7

Target: P2RX7 (Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7))

Andere Bezeichnung: P2RX7

Hintergrund: The product P2RX7 belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression.
Alias Symbols: P2X7
Protein Interaction Partner: KRTAP10-8, KRT31, TM9SF1, CASK, EFNB3, EMP3, PANX1, SVIL, ACTB,
Protein Size: 595

Molekulargewicht: 69 kDa

Gen-ID: 5027

UniProt: Q99572

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Vesicle Exocytosis