ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 6 (ABCB6) Antikörper

Antigen: ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 6 (ABCB6)

Synonyme: ABC, PRP, umat, ABC14, MTABC3, EST45597, FLJ22414, 1200005B17Rik, MGC93242, ABCB6, ABCA6, abcb6, MGC145484

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Rind (Kuh), Maus, Ratte (Rattus)

Applikation: ELISA, Western Blot (WB), Immunpräzipitation (IP)

Produktnummer: ABIN129698

Produktbeschreibung

Weitere Bezeichnung: ABCB6 (ATP-Binding Cassette Sub-Family B Member 6)

Swiss-Prot: Q9NP58

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeatedimmunizations with a synthetic peptide corresponding to amino acids 440-455 of human ABCB6 protein. Protein Sequence: Human ABCB6, 842 aa, predicted MW 93.9 kDa 1 mvtvgnycea egpvgpawmq dglspcffft lvpstrmalg tlalvlalpc rrrerpagad 61 slswgagpri spyvlqllla tlqaalplag lagrvgtarg aplpsyllla svleslagac 121 glwllvvers qarqrlamgi wikfrhspgl lllwtvafaa enlalvswns pqwwwaradl 181 gqqvqfslwv lryvvsgglf vlglwapglr pqsytlqvhe edqdversqv rsaaqqstwr 241 dfgrklrlls gylwprgspa lqlvvliclg lmgleralnv lvpifyrniv nlltekapwn 301 slawtvtsyv flkflqgggt gstgfvsnlr tflwirvqqf tsrrvellif shlhelslrw 361 hlgrrtgevl riadrgtssv tgllsylvfn viptladiii giiyfsmffn awfglivflc 421 mslyltltiv vtewrtkfrr amntqenatr aravdsllnf etvkyynaes yeveryreai 481 ikyqglewks saslvllnqt qnlviglgll agsllcayfv teqklqvgdy vlfgtyiiql 541 ymplnwfgty yrmiqtnfid menmfdllke etevkdlpga gplrfqkgri efenvhfsya 601 dgretlqdvs ftvmpgqtla lvgpsgagks tilrllfrfy dissgcirid gqdisqvtqa 661 slrshigvvp qdtvlfndti adnirygrvt agndeveaaa qaagihdaim afpegyrtqv 721 gerglklsgg ekqrvaiart ilkapgiill deatsaldts neraiqasla kvcanrttiv 781 vahrlstvvn adqilvikdg civergrhea llsrggvyad mwqlqqgqee tsedtkpqtm 841 er

Format: Liquid (sterile filtered)

Beschreibung: ABCB6 (ATP-binding cassette sub-family Bmember 6, also known as mitochondrialprecursor ABC transporter 3, Mt-ABCtransporter 3, and ABC transporter umat)is a member of the superfamily of ATP-binding cassette (ABC) transporters.ABCB6 is a membrane-associatedprotein that transports various moleculesacross the extra- and intra-cellularmembranes. ABC genes are divided intoseven distinct subfamilies (ABC1, DR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of theMDR/TAP subfamily confer multi-drug resistance (MDR) to cancer cells and are also involved in antigen presentation.ABCB6 also likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate genefor lethal neonatal metabolic syndrome, a disorder of mitochondrial function.

Spezifität: This affinity-purified antibody is directed against human ABCB6 protein. The product wasaffinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used tosuggest cross reactivity with ABCB6 protein from human and dog based on 100% homology with the immunizingsequence. Expect partial reactivity with ABCB6 from mouse and rat sources based on partial (~93%, 15/16)sequence homology. Reactivity against homologues from other sources is not known.

Anwendungen

Applikationshinweise: This affinity-purified antibody has been tested for use in ELISA and western blot. Specificconditions for reactivity should be optimized by the end user. Expect a band approximately 94 kDa in sizecorresponding to ABCB6 protein by western blotting in the appropriate cell lysate or extract. Dilutions: ELISA 1:40,000 - 1:200,000 WESTERN BLOT 1:1,000 - 1:5,000 IF MICROSCOPY User Optimized OTHER APPLICATION User Optimized

Konzentration: 1.37 mg/ml (by UV absorbance at 280 nm)

Buffer: Stabilizer: None. Preservative: 0.01% (w/v) Sodium Azide. Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2.

Lagerung: Store vial at -20°C prior to opening. Dilute only prior toimmediate use. For extended storagealiquot contents and freeze at -20° C orbelow. Avoid cycles of freezing andthawing. Expiration date is one (1)year from date of opening.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 6 (ABCB6) antibody

1.37 mg/ml (by UV absorbance at 280 nm)

Publikationen

Publikationen: Fukuda, Aguilar-Bryan, Vaxillaire et al.: "Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC) transporters ABCB6 and sulfonylurea receptor 1 (SUR1)/ABCC8." in: The Journal of biological chemistry, Vol. 286, Issue 10, pp. 8481-92, 2011 (PubMed).