ZIC2 (ZIC2) Antikörper

Antigen: ZIC2 (ZIC2)

Synonyme: HPE5

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Rind (Kuh), Maus, Ratte (Rattus)

Applikation: ELISA, Western Blot (WB), Immunpräzipitation (IP)

Produktnummer: ABIN129629

Produktbeschreibung

Weitere Bezeichnung: ZIC-2

Gen-ID: NP_009060

Swiss-Prot: O95409

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizationswith a synthetic peptide corresponding amino acids 189-206 of Mouse ZIC-2.

Format: Liquid (sterile filtered)

Beschreibung: ZIC2 (also known as zinc finger protein of thecerebellum 2, HPE5, Zic family member 2 and odd-pairedDrosophila homolog) is a nuclear protein that functions as a transcriptional repressor and may regulate tissue specificexpression of dopamine receptor D1. In mouse, knockout of Zic1 leads to aplasia of cerebellum and skeletal abnormalities. Mutation in Zic2 and Zic3 in mouse and/orhuman cause holoprosencephaly and heterotaxis,respectively. Holoprosencephaly is the most commonstructural anomaly of the human brain.

Spezifität: This affinity purified antibody is directed against mouse ZIC2 protein. The product was affinitypurified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest reactivitywith this protein from human, chimpanzee, mouse, rat and dog based on 100% homology for the immunogen sequence.Expect cross reactivity with ZIC2 from chicken, zebrafish and frog as the core 16 amino acid residues within the immunogen sequence show very high degrees of homology with ZIC2 from these sources. Cross reactivity with ZIC2homologues from other sources has not been determined.

Anwendungen

Applikationshinweise: This affinity purified antibody has been tested for use in ELISA and by western blot. Specific conditions for reactivity should be optimized by the enduser. Expect a band approximately 55 kDa in sizecorresponding to ZIC2 by western blotting in the appropriate cell lysate or extract.

Konzentration: 1.0 mg/ml (by UV absorbance at 280 nm)

Buffer: Stabilizer: None. Preservative: 0.01% (w/v) Sodium Azide. Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2.

Lagerung: Store vial at -20° C prior to opening. Dilute only prior to immediate use. For extended storagealiquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) yearfrom date of opening.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-ZIC2 (ZIC2) antibody