CGRP Antikörper (AA 23-37)

Produktnummer ABIN112616

Der Ziege Polyklonal anti-CGRP Antikörper wird verwendet zum Nachweis von CGRP in Proben von Ratte, Maus und Reptile. Er wurde validiert für IHC (p), IF und EIA.

Kurzübersicht für CGRP Antikörper (AA 23-37) (ABIN112616)

Target: CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))

Reaktivität: Ratte, Maus, Reptile

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser CGRP Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-CGRP Antikörper

Bindungsspezifität: AA 23-37

Spezifität: Recognizes Calcitonin gene-related peptide, also known as CGRP, a neuropeptide that acts as a vasodilator and may play a role in migraine. This antibody is reactive with both whole molecule (1-37) and the C-terminal (23-37). Specifically visualises CGRP in brain cells.

Aufreinigung: Affinity Chromatography on Protein G

Immunogen: Synthetic Rat Tyr-CGRP (23-37) conjugated to gamma globulin

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA (1/500-1/2500). Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 5.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CGRP

Target: CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))

Andere Bezeichnung: CGRP / CALCA

Hintergrund: CGRP is present in C-cells of the thyroid and in central and peripheral nerves. CGRP has several important physiologic roles: it is a potent vasodilator, and can affect the force and rate of heart beat, it can modulate acetylcholine receptor function at the neuromuscular junction, it has been demonstrated to block tolerance to morphine, and it can modulate antigen presentation in Langerhans cells in the skin. Despite these important physiologic functions, therapeutic strategies using CGRP have been impeded due to the lack of a cloned CGRP receptor with which ligands could be developed.Synonyms: Alpha-type CGRP, CALC1, CGRP-I, Calcitonin gene-related peptide I

Gen-ID: 24241

NCBI Accession: NP_001029127

UniProt: P01256

Pathways: Hormone Activity, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, Feeding Behaviour