Gai2 (Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide-2) Antikörper

Antigen: Gai2 (Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide-2)

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunpräzipitation (IP), Western Blot (WB)

Produktnummer: ABIN110589

Produktbeschreibung

Format: Protein A purified, 0.1% sodium azide, Lyophilized

Beschreibung: Gai2 is a 40-41 kDa alpha-subunit of heterotrimeric protein, that shares sequence homology with Gai3 and Gai1. All these G proteins can be ADP-ribosylated at the carboxy terminal Cys of the CAAX sequence, interfering with receptor coupling. Gai2 is expressed widely in tissues and cell lines. Activation of PLC-ß by Gai-coupled receptors is the result of release of Gß. subunits from Gai. Gai2regulates potassium channel activation. Mutation at Arg179 has been identified in tumors. This and the Q205L mutant inhibit adenylyl cyclase.

Anwendungen

Lagerung: 4°C for short term storage or -20°C in small aliquots for long term storage. Avoid repeated freeze and thaw. Reconstitute to 1 mg/ml by adding 200 µl PBS

Beschränkungen: Nur für Forschungszwecke einsetzbar