Carcinoembryonic Antigen-Related Cell Adhesion Molecule 7 (CEACAM7) Antikörper

Antigen: Carcinoembryonic Antigen-Related Cell Adhesion Molecule 7 (CEACAM7)

Synonyme: CEA, CGM2, CEACAM7

Klonalität: Monoklonal (BAC2)

Wirt: Maus

Reaktivität: Human

Applikation: Durchflusszytometrie (FACS), Zell-ELISA (cELISA)

Produktnummer: ABIN108732

Produktbeschreibung

Weitere Bezeichnung: CEACAM7 (CGM2)

Immunogen: immunisation with a CEACAM7/Fc fusion protein

Format: Purified

Isotyp: IgG1

Klon: BAC2

Beschreibung: CEA-related cell adhesion molecule 7 (CEACAM7, CGM2) belongs to the carcinoembryonic antigen (CEA) family (1). It encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein which is only found on the apical surface of highly differentiated epithelial cells adult colon and on a small epithelial cell population in pancreatic ducts (2). CEACAM7 expression is completely lost upon malignant transformation already in hyperplastic polyps and early adenomas as well as in adenocarcinomas of the colon (2). Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by one immunoglobulin constantlike A domain.

Spezifität: Anti-human CEACAM7 (CGM2)

Anwendungen

Applikationshinweise: Flow cytometry: 1.2 ug/10^6 cells. CELISA: 1:200 - 1:400.

Konzentration: 1mg/ml

Reinigung: Protein G

Buffer: phosphate buffered saline, pH 7.2

Lagerung: Short term: 2°C - 8°C. Long term: -20°C (avoid repeated freezing and thawing)

Forschungsgebiet: Krebs

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Specificity testing of BAC2. Members of the CEACAM family were expressed on BOSC cells after transient transfection with expression vectors containing either the cDNA of CEACAM1, 5, 6, 7, 8 or a recombinant transmembrane- anchored PSG1 fusion protein. Re

FACS analysis of BOSC23 cells using BAC2.BOSC23 cells were transiently transfected with an expression vectorencoding either CEACAM7 (red curve) or an irrelevant protein (control transfectant). Binding of BAC2 was detected with a PE conjugatedsecondary an

Publikationen

Publikationen: Schoelzel, Zimmermann, Schwarzkopf et al.: "Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas." in: The American journal of pathology, Vol. 156, Issue 2, pp. 595-605, 2000 (PubMed).

Kilic, Oliveira-Ferrer, Neshat-Vahid et al.: "Lymphatic reprogramming of microvascular endothelial cells by CEA-related cell adhesion molecule-1 via interaction with VEGFR-3 and Prox1." in: Blood, Vol. 110, Issue 13, pp. 4223-33, 2007 (PubMed).