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Produktdetails

anti-CEACAM1 (biliary glycoprotein I, BGP, CD66a) Antikörper

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Bild für anti-CEACAM1 (biliary glycoprotein I, BGP, CD66a) Antikörper
Antigen: CEACAM1 (biliary glycoprotein I, BGP, CD66a)
Klonalität: Monoklonal (GM8G5)
Applikation: Durchflusszytometrie (FACS), Cell-ELISA (cELISA), Immunhistochemie (IHC)
Reaktivität: Human
Wirt: Maus
5 Publikationen vorhanden 5 Publikationen vorhanden
Menge: 100 ug
Preis: 250,00 €   (Zzgl. Versandkosten und MWSt)
Bestellnummer: ABIN108725
Verfügbarkeit: Versandbereit innerhalb von 1 bis 2 Werktagen
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Produktbeschreibung  » anti-CEACAM1 (biliary glycoprotein I, BGP, CD66a) Antikörper

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Antigen CEACAM1 (biliary glycoprotein I, BGP, CD66a)
Immunogen GM8G5 was generated by genetic immunisation of BALB/c mice with an immunisation vector containing the cDNA of the human CEACAM1-A2 domain. The antibody was purified by protein G affinity chromatography from cell culture supernatants and is routinely test
Reaktivität Human
Wirt Maus
Klonalität Monoklonal
Format Purified
Isotyp IgG1 »Passende Sekundärantikörper
Beschreibung CEACAM1 (BGP) belongs to the carcinoembryonic antigen (CEA) gene family. It is expressed on cells of epithelial and myeloid origin. CEACAM1 expression is downregulated in many tumors indicating a tumor - suppressive function. The antitumor effect may be due to inhibition of tumor angiogenesis, possibly by increased secretion of antiangiogenic molecules from the cells. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by two immunoglobulin constant-like A (A1, A2) and one B domain. While the N, A1 and B domains can also be found in other CEA-family members, the A2 domain of CEACAM1 differs from those found in other CEACAM.
Klon GM8G5
Spezifität GM8G5 recognises CEACAM1 transiently expressed on the cell surface of transfected BOSC cells (Fig. 1) as well as the naturally expressed protein (Fig. 2, kindly provided by Dr. R. Riesenberg, Labor für Tumorimmunologie, Urologische Klinik, Klinikum Grossh

Anwendungen  » anti-CEACAM1 (biliary glycoprotein I, BGP, CD66a) Antikörper

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Applikation Durchflusszytometrie (FACS), Cell-ELISA (cELISA), Immunhistochemie (IHC)
» Hier finden Sie 6 Protokolle zu den gelisteten Anwendungen
Applikationshinweise GM8G5 has been tested for the use in flow cytometry, cell-ELISA and immunohistology on cryo-sections (Fig. 3, kindly provided by Prof. M. Neumaier, Institut für Klinische Chemie, Universitätsklinikum Mannheim). It is expected that the antibody will be su
Lagerung Store the antibody at 4°C. Avoid repeated freezing and thawing.
Forschungsgebiet Rezeptoren, Immunologie, Krebs, Rezeptoren, Zell-/Gewebemarker, Krebs
Beschränkungen Nur für Forschungszwecke einsetzbar

Publikationen  » anti-CEACAM1 (biliary glycoprotein I, BGP, CD66a) Antikörper

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Publikationen Kammerer, Riesenberg, Weiler et al.: "The tumour suppressor gene CEACAM1 is completely but reversibly downregulated in renal cell carcinoma." In: The Journal of pathology, Vol. 204, Issue 3, pp. 258-67, 2004 (PubMed)

Beau, Berger, Servin: "Rotavirus impairs the biosynthesis of brush-border-associated dipeptidyl peptidase IV in human enterocyte-like Caco-2/TC7 cells." In: Cellular microbiology, Vol. 9, Issue 3, pp. 779-89, 2007 (PubMed)

Yoon, Terada, Kita: "CD66b regulates adhesion and activation of human eosinophils." In: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 12, pp. 8454-62, 2007 (PubMed)

Thomas, Zhu, Schnaar et al.: "Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow." In: The Journal of biological chemistry, Vol. 283, Issue 23, pp. 15647-55, 2008 (PubMed)

Suemiramoth, Gleizes, Turbica et al.: "Escherichia coli type 1 pili trigger late IL-8 production by neutrophil-like differentiated PLB-985 cells through a Src family kinase- and MAPK-dependent mechanism." In: Journal of leukocyte biology, Vol. 85, Issue 2, pp. 310-21, 2009 (PubMed)