Integrin beta 3 (ITGB3) Antikörper

Antigen: Integrin beta 3 (ITGB3)

Synonyme: LAD, CD18, MF17, MFI7, LCAMB, LFA-1, MAC-1, CD61, GP3A, GPIIIa, INGRB3, MGC159221, MGC159223, integrin, ITGB3

Klonalität: Monoklonal (BB10)

Wirt: Maus

Reaktivität: Human

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN108422

Produktbeschreibung

Weitere Bezeichnung: Integrin, beta3

Immunogen: Monoclonal antibody to b3 integrin is derived from the hybridoma produced by fusion between myeloma cells and Balb/c spleen cells. Partially purified platelet glycoprotein IIb/IIIa complex was used as an immunogen

Format: Purified

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: BB10

Beschreibung: Monoclonal Antibody to Human Integrins

Spezifität: The antibody reacts with b3 integrin including the GPIIIa of platelets.

Anwendungen

Applikationshinweise: No reactivity with paraffin sections. Working dilution in western blotting is at least 1:1000

Lagerung: This product should be stored at +2 C to +8 C

Forschungsgebiet: Extrazelluläre Matrix

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Human primary fibroblasts (MAb BB10, b3-Integrin)

Publikationen

Publikationen: Korhonen M, Ylanne J, Laitinen L et al.: "Distribution of beta 1 and beta 3 integrins in human fetal and adult kidney." in: Lab Invest, Vol. 62, Issue 5, pp. 616-25, 1990 (PubMed).

Ylanne J, Virtanen I: "The Mr 140,000 fibronectin receptor complex in normal and virus-transformed human fibroblasts and in fibrosarcoma cells: identical localization and function." in: Int J Cancer, Vol. 43, Issue 6, pp. 1126-36, 1989 (PubMed).

Ylanne J, Hormia M, Jarvinen M et al.: "Platelet glycoprotein IIb/IIIa complex in cultured cells. Localization in focal adhesion sites in spreading HEL cells." in: Blood, Vol. 72, Issue 5, pp. 1478-86, 1988 (PubMed).

Ylanne J, Huuskonen J, O'Toole TE et al.: "Mutation of the cytoplasmic domain of the integrin beta 3 subunit. Differential effects on cell spreading, recruitment to adhesion plaques, endocytosis, and phagocytosis." in: J Biol Chem, Vol. 270, Issue 16, pp. 9550-7, 1995 (PubMed).

Koukoulis GK, Shen J, Monson R et al.: "Pleural mesotheliomas have an integrin profile distinct from visceral carcinomas." in: Hum Pathol, Vol. 28, Issue 1, pp. 84-90, 1997 (PubMed).

Lohi J, Leivo I, Franssila K et al.: "Changes in the distribution of integrins and their basement membrane ligands during development of human thyroid follicular epithelium." in: Histochem J, Vol. 29, Issue 4, pp. 337-45, 1997 (PubMed).

Kaapa A, Peter K, Ylanne J: "Effects of mutations in the cytoplasmic domain of integrin beta(1) to talin binding and cell spreading." in: Exp Cell Res, Vol. 250, Issue 2, pp. 524-34, 1999 (PubMed).

Li TF, Xu JW, Santavirta S et al.: "Expression of vitronectin and its integrin receptors in the synovial membrane-like interface tissue from aseptic loosening of total hip replacement." in: J Rheumatol, Vol. 27, Issue 3, pp. 727-34, 2000 (PubMed).