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study identifies the AIM2 (zeige AIM2 Proteine) inflammasome and cGAS/IFI16 (zeige IFI16 Proteine)-STING-type I IFN pathway as a novel mechanism for host innate immunity to the ALVAC vaccine vector.
NEMO (zeige IKBKG Proteine) was critically involved in the cGAS-STING pathway.
Studied association of genetic variants of the MAVS, MITA and MFN2 genes with leprosy in Han Chinese from Southwest China; found no association between the variants and susceptibility to leprosy.
both IL-6 (zeige IL6 Proteine) and RIG-I (zeige DDX58 Proteine) are downstream molecules of STING along the DNA sensor pathway.
We discuss three newly described monogenic autoinflammatory diseases [deficiency of adenosine deaminase 2 (zeige CECR1 Proteine) (DADA2), a subtype of macrophage activation syndrome (MAS (zeige MAS1 Proteine)), and stimulator of interferon (zeige IFNA Proteine) genes (STING)-associated vasculopathy with onset in infancy (SAVI)], discuss the possibilities of somatic mosaicism and digenic inheritance, and give an update on new concepts in pathways involved in familial Mediterranean fever (zeige MEFV Proteine)
Structural analysis indicates that the 3 disease-associated mutations at positions 206, 281, and 284 of the STING protein define a novel cluster of amino acids with functional importance in the regulation of type I interferon (zeige IFNA Proteine) signaling
a critical role of p38 (zeige CRK Proteine)-mediated USP21 (zeige USP21 Proteine) phosphorylation in regulating STING-mediated antiviral functions and identifies p38 (zeige CRK Proteine)-USP21 (zeige USP21 Proteine) axis as an important pathway that DNA virus adopts to avoid innate immunity responses.
We conclude that the R71H-G230A-R293Q (HAQ) of TMEM173 is a null TMEM173 allele.
Human herpesvirus 1 ICP27 interacted with TBK1 (zeige TBK1 Proteine) and STING in a manner that was dependent on TBK1 (zeige TBK1 Proteine) activity and the RGG motif in ICP27 and inhibited type I IFN induction through the cGAS-STING-TBK1 (zeige TBK1 Proteine) pathway in human macrophages.
Multivariate analysis supported TMEM173 as an independent prognostic factor.
to contain the spread of herpes simplex virus type 1 in vivo, STING-dependent signaling leads to the upregulation of tetherin (zeige BST2 Proteine), a viral restriction factor
found that CCCP impairs the interaction between STING and TBK1 (zeige TBK1 Proteine) and concomitantly triggers mitochondria fission.
Yersinia YopJ negatively regulates IRF3 (zeige IRF3 Proteine)-mediated antibacterial response through disruption of STING-mediated cytosolic DNA signaling.
demonstrate that in colon tumor model, therapeutic anti-CD47 (zeige CD47 Proteine) preferentially relies on STING-mediated DNA sensing in dendritic cells
STING is a central mediator of interferon (zeige IFNA Proteine) regulated inflammasome activation in Chlamydia trachomatis infection.
this study shows that immune rejection of prostate cancer cells relies on Mus81 (zeige MUS81 Proteine) and STING
TRIF (zeige RNF138 Proteine) and STING interacted directly, through their carboxy-terminal domains, to promote STING dimerization, intermembrane translocation, and signaling.
Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti- viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
transmembrane protein 173
, N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner
, endoplasmic reticulum IFN stimulator
, endoplasmic reticulum interferon stimulator
, mediator of IRF3 activation
, mitochondrial mediator of IRF3 activation
, stimulator of interferon genes protein
, Stimulator of interferon genes protein
, mitochondrial transmembrane protein 173