TMEM173 Proteine (TMEM173)

Bezeichnung:
Transmembrane Protein 173 Proteine (TMEM173)
Auf www.antikoerper-online.de finden Sie aktuell 11 Transmembrane Protein 173 (TMEM173) Proteine von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TMEM173 Antikörper (143) und TMEM173 Kits (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 164 TMEM173 Produkte verfügbar.
Synonyme:
2610307O08Rik, ERIS, Mita, MPYS, NET23, RGD1562552, STING
alle Proteine anzeigen Gen GeneID UniProt
TMEM173 340061 Q86WV6
TMEM173 72512 Q3TBT3
TMEM173 498840  

Weitere Synonyme anzeigen

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Weitere Proteine zu TMEM173 Interaktionspartnern

Human Transmembrane Protein 173 (TMEM173) Interaktionspartner

  1. both IL-6 (zeige IL6 Proteine) and RIG-I (zeige DDX58 Proteine) are downstream molecules of STING along the DNA sensor pathway.

  2. We discuss three newly described monogenic autoinflammatory diseases [deficiency of adenosine deaminase 2 (zeige CECR1 Proteine) (DADA2), a subtype of macrophage activation syndrome (MAS (zeige MAS1 Proteine)), and stimulator of interferon (zeige IFNA Proteine) genes (STING)-associated vasculopathy with onset in infancy (SAVI)], discuss the possibilities of somatic mosaicism and digenic inheritance, and give an update on new concepts in pathways involved in familial Mediterranean fever (zeige MEFV Proteine)

  3. Structural analysis indicates that the 3 disease-associated mutations at positions 206, 281, and 284 of the STING protein define a novel cluster of amino acids with functional importance in the regulation of type I interferon (zeige IFNA Proteine) signaling

  4. a critical role of p38 (zeige CRK Proteine)-mediated USP21 (zeige USP21 Proteine) phosphorylation in regulating STING-mediated antiviral functions and identifies p38 (zeige CRK Proteine)-USP21 (zeige USP21 Proteine) axis as an important pathway that DNA virus adopts to avoid innate immunity responses.

  5. We conclude that the R71H-G230A-R293Q (HAQ) of TMEM173 is a null TMEM173 allele.

  6. Human herpesvirus 1 ICP27 interacted with TBK1 (zeige TBK1 Proteine) and STING in a manner that was dependent on TBK1 (zeige TBK1 Proteine) activity and the RGG motif in ICP27 and inhibited type I IFN induction through the cGAS-STING-TBK1 (zeige TBK1 Proteine) pathway in human macrophages.

  7. Multivariate analysis supported TMEM173 as an independent prognostic factor.

  8. The mitochondrial damage-cGAS-STING-IRF3 (zeige IRF3 Proteine) pathway is critically involved in metabolic stress-induced endothelial inflammation.

  9. These data uncover a promycobacterial role for STING-dependent OASL (zeige OASL Proteine) production during Mycobacterium leprae infection that directs the host immune response toward a niche that permits survival of the pathogen.

  10. cGAs recognizes bacterial/viral DNA, and is a strong activator of STING that can further activate IRF3 (zeige IRF3 Proteine) and subsequent type I interferon (zeige IFNA Proteine) production. (Review)

Mouse (Murine) Transmembrane Protein 173 (TMEM173) Interaktionspartner

  1. Yersinia YopJ negatively regulates IRF3 (zeige IRF3 Proteine)-mediated antibacterial response through disruption of STING-mediated cytosolic DNA signaling.

  2. demonstrate that in colon tumor model, therapeutic anti-CD47 (zeige CD47 Proteine) preferentially relies on STING-mediated DNA sensing in dendritic cells

  3. STING is a central mediator of interferon (zeige IFNA Proteine) regulated inflammasome activation in Chlamydia trachomatis infection.

  4. this study shows that immune rejection of prostate cancer cells relies on Mus81 (zeige MUS81 Proteine) and STING

  5. TRIF (zeige RNF138 Proteine) and STING interacted directly, through their carboxy-terminal domains, to promote STING dimerization, intermembrane translocation, and signaling.

  6. We conclude that the R71H-G230A-R293Q (HAQ) of TMEM173 is a null TMEM173 allele.

  7. results show that resistance to HSV-1 in the trigeminal ganglia during acute infection is conferred in part by STING and IFN-alpha (zeige IFNA Proteine)/beta signaling in both bone marrow-derived and -resident cells, which coalesce to support a robust HSV-1-specific CD8 (zeige CD8A Proteine)(+) T cell response

  8. results suggest that LSm14A (zeige LSM14A Proteine) plays an important role in antiviral innate and adaptive immune responses by modulating MITA level in a cell type-specific manner

  9. STING and TRIF (zeige RNF138 Proteine) Contribute to Mouse Sepsis, Depending on Severity of the Disease Model

  10. Data suggest that activation of either RIG-I (zeige DDX58 Proteine)/MAVS (zeige MAVS Proteine) or STING pathways during acute intestinal tissue injury in mice resulted in IFN-I signaling that maintained gut (zeige GUSB Proteine) epithelial barrier integrity and reduced GVHD severity.

Pig (Porcine) Transmembrane Protein 173 (TMEM173) Interaktionspartner

TMEM173 Protein Überblick

Protein Überblick

Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti- viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.

Alternative names and synonyms associated with TMEM173

  • transmembrane protein 173 (TMEM173)
  • transmembrane protein 173 (Tmem173)
  • 2610307O08Rik Protein
  • ERIS Protein
  • Mita Protein
  • MPYS Protein
  • NET23 Protein
  • RGD1562552 Protein
  • STING Protein

Bezeichner auf Proteinebene für TMEM173

transmembrane protein 173 , N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner , endoplasmic reticulum IFN stimulator , endoplasmic reticulum interferon stimulator , hMITA , hSTING , mediator of IRF3 activation , mitochondrial mediator of IRF3 activation , stimulator of interferon genes protein , MMITA , mSTING , Stimulator of interferon genes protein , mitochondrial transmembrane protein 173

GENE ID SPEZIES
606815 Canis lupus familiaris
462107 Pan troglodytes
694353 Macaca mulatta
100459760 Pongo abelii
340061 Homo sapiens
72512 Mus musculus
533661 Bos taurus
768990 Gallus gallus
100217389 Sus scrofa
498840 Rattus norvegicus
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