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JunB (zeige JUNB ELISA Kits) neddylation mediated by Itch promotes its ubiquitination-dependent degradation.
Describe an autoinhibitory mechanism for ITCH ubiquitin ligase involving a linker-HECT domain interaction. This intramolecular interaction traps the HECT enzyme in its inactive state and can be relieved by linker phosphorylation.
Data show that the E3 ubiquitin ligase Itch forms a complex with tricellulin (zeige MARVELD2 ELISA Kits) and thereby enhances its ubiquitination.
ASPP2 (zeige TP53BP2 ELISA Kits) suppresses invasion, peritoneal dissemination and TGF-beta1 (zeige TGFB1 ELISA Kits)-induced EMT (zeige ITK ELISA Kits) by inhibiting Smad7 (zeige SMAD7 ELISA Kits) degradation mediated by ITCH in gastric cancer cells.
WBP2 (zeige WBP2 ELISA Kits)/ITCH signaling functions to link the intricate Wnt (zeige WNT2 ELISA Kits) and Hippo signaling networks in breast cancer.
The cellular ubiquitin ligase, Itch, is required for Kaposi's sarcoma herpesvirus RTA (zeige RBM9 ELISA Kits) induced degradation of vFLIP.
Results indicate that TAX1BP1 (zeige TAX1BP1 ELISA Kits) functions as an adaptor molecule for Itch to target MAVS (zeige MAVS ELISA Kits) during RNA virus infection and thus restrict virus-induced apoptosis.
These data demonstrate that Itch, ubiquitin, and Alix (zeige PDCD6IP ELISA Kits) control the BFRF1-mediated modulation of the nuclear envelope and human herpesvirus 4 maturation, uncovering novel regulatory mechanisms of nuclear egress of viral nucleocapsids.
The authors demonstrate that the PPxY L domain motif of ebolavirus VP40 interacts specifically with the WW domain of the host E3 ubiquitin ligase ITCH.
Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch.
this study identified a previously unknown role for Itch in regulating IL-17 (zeige IL17A ELISA Kits)-mediated colonic inflammation and carcinogenesis
Itch monoubiquitinates SMN (zeige STMN1 ELISA Kits) and monoubiquitination of SMN (zeige STMN1 ELISA Kits) plays an important role in regulating its cellular localization.
ITCH targets TXNIP (zeige TXNIP ELISA Kits) for ubiquitin-proteasome degradation in cardiomyocytes and ameliorates reactive oxygen species-induced cardiotoxicity through the thioredoxin (zeige TXN ELISA Kits) system.
CUL4B links two distinct spermatogenetic processes to a single E3 ligase, highlighting the significance of ubiquitin modification during spermatogenesis.
Impaired ITCH results in heightened TNF (zeige TNF ELISA Kits) signaling. ITCH-/- mouse's spontaneous lung inflammation and subsequent death can be delayed when TNF (zeige TNF ELISA Kits) signaling is genetically deleted.
ITCH modulates SIRT6 (zeige SIRT6 ELISA Kits) and SREBP2 (zeige SREBF2 ELISA Kits) to influence lipid metabolism and atherosclerosis in ApoE (zeige APOE ELISA Kits) null mice
In the absence of Ndfip1, the Nedd4 family member Itch can bind an E2 but cannot accept ubiquitin onto its catalytic cysteine.
The E3 ubiquitin ligase Itch inhibits p38alpha (zeige MAPK14 ELISA Kits) signaling and skin inflammation through the ubiquitylation of Tab1 (zeige TAB1 ELISA Kits).
Ndfip1 (zeige NDFIP1 ELISA Kits) regulates itch ligase activity and airway inflammation via UbcH7 (zeige UBE2L3 ELISA Kits).
The expression of Th2 cytokines by Treg cells was increased in the absence of Itch. Fate mapping revealed that a fraction of Treg cells lost Foxp3 (zeige FOXP3 ELISA Kits) expression independently of Itch.
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
E3 ubiquitin-protein ligase Itchy homolog
, NFE2-associated polypeptide 1
, atrophin-1 interacting protein 4
, dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4))
, itchy E3 ubiquitin protein ligase homolog
, E3 ubiquitin-protein ligase Itchy