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anti-Spen Homolog, Transcriptional Regulator (Drosophila) (SPEN) Antikörper

SPEN encodes a hormone inducible transcriptional repressor.

Alle Antikörper anzeigen Gen GeneID UniProt
SPEN 64783 Q96T37
SPEN 56381 Q62504
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Top anti-SPEN Antikörper auf antikoerper-online.de

Showing 10 out of 20 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Ziege Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 3 bis 4 Tage
249,70 €
Details
Human Ziege Unkonjugiert ELISA   0.1 mg Anmelden zum Anzeigen 2 bis 4 Tage
302,50 €
Details
Human Kaninchen Unkonjugiert IP Western Blot: SHARP Antibody [ABIN188790] - Detection of Human SHARP by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-SHARP antibody ABIN188790 used for IP at 3 mcg/mg lysate. SHARP was also immunoprecipitated by rabbit anti-SHARP antibody ABIN188789, which recognizes an upstream epitope.  Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Anmelden zum Anzeigen 2 bis 4 Tage
463,75 €
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), IP Immunohistochemistry-Paraffin: SPEN Antibody [NBP1-82952] - Staining of human rectum shows strong nuclear and slightly weaker cytoplasmic positivity in glandular cells. Immunocytochemistry/Immunofluorescence: SPEN Antibody [NBP1-82952] - Staining of human cell line U-251MG shows positivity in nuclei but not nucleoli. 0.1 mL Anmelden zum Anzeigen 2 bis 4 Tage
418,75 €
Details
Human Kaninchen Unkonjugiert IP, WB Western Blot: SHARP Antibody [ABIN188789] - Detection of Human SHARP by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-SHARP antibody ABIN188789 used for IP at 3 mcg/mg lysate. SHARP was also immunoprecipitated by rabbit anti-SHARP antibody ABIN188790, which recognizes a downstream epitope.  Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Anmelden zum Anzeigen 2 bis 4 Tage
463,75 €
Details
Human Ziege Unkonjugiert ELISA   100 μg Anmelden zum Anzeigen 11 bis 14 Tage
495,88 €
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Human Ziege APC ELISA   100 μL Anmelden zum Anzeigen 20 bis 21 Tage
678,37 €
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Human Ziege FITC ELISA   100 μL Anmelden zum Anzeigen 20 bis 21 Tage
678,37 €
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Human Ziege PE ELISA   100 μL Anmelden zum Anzeigen 20 bis 21 Tage
678,37 €
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Human Ziege Biotin ELISA   100 μL Anmelden zum Anzeigen 20 bis 21 Tage
678,37 €
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SPEN Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Human , ,
,

, , , , ,
Mouse (Murine)


Am meisten referenzierte anti-SPEN Antikörper

  1. Human Polyclonal SPEN Primary Antibody für ICC, IF - ABIN4355627 : McHugh, Chen, Chow, Surka, Tran, McDonel, Pandya-Jones, Blanco, Burghard, Moradian, Sweredoski, Shishkin, Su, Lander, Hess, Plath, Guttman: The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3. in Nature 2015 (PubMed)

  2. Human Polyclonal SPEN Primary Antibody für ELISA - ABIN251251 : Hiriart, Gruffat, Buisson, Mikaelian, Keppler, Meresse, Mercher, Bernard, Sergeant, Manet: Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export. in The Journal of biological chemistry 2005 (PubMed)

Weitere Antikörper gegen SPEN Interaktionspartner

Human Spen Homolog, Transcriptional Regulator (Drosophila) (SPEN) Interaktionspartner

  1. The authors demonstrate that RBM15 (zeige RBM15 Antikörper) is methylated by protein arginine methyltransferase 1 (PRMT1 (zeige PRMT1 Antikörper)) at residue R578, leading to its degradation via ubiquitylation by an E3 ligase (CNOT4 (zeige CNOT4 Antikörper)).

  2. SPEN is a novel tumor-suppressor gene that may be clinically useful as a predictive biomarker of tamoxifen response in ERalpha (zeige ESR1 Antikörper)-positive breast cancers.

  3. SPEN mutations were associated with diffuse large B-cell lymphoma with hepatitis C virus infection.

  4. OTT1 regulates the alternative splicing of Mpl (zeige MPL Antikörper)-TR, a truncated isoform of c-Mpl (zeige MPL Antikörper), which modulates Thrombopoietin (zeige THPO Antikörper)-mediated signaling.

  5. Phosphorylation of the CK2 (zeige CSNK2A1 Antikörper) site on SMRT (zeige NCOR2 Antikörper) significantly increased affinity for SHARP.

  6. RBM15 does indeed play a critical role in the survival of chronic myelogenous leukemia (CML) cells, which may have potential application in designing molecular therapies for CML treatment.

  7. both Rbm15 (zeige RBM15 Antikörper) and the leukemogenic Rbm15 (zeige RBM15 Antikörper)-Mkl1 (zeige MKL1 Antikörper) fusion protein interact with the Setd1b (zeige SETD1B Antikörper) histone H3 (zeige HIST3H3 Antikörper)-Lys4 methyltransferase

  8. These results demonstrate a role for the inactivation of SHARP transcription in DM1 biology.

  9. A four-way variant translocation originating the RBM15 (zeige RBM15 Antikörper)-MKL1 (zeige MKL1 Antikörper) fusion gene is associated with acute megakaryoblastic leukemia.

  10. HHV-8 ORF57 interacts with RBM15 (zeige RBM15 Antikörper) and OTT3 (zeige RBM15B Antikörper) to promote expression of viral intronless genes.

Mouse (Murine) Spen Homolog, Transcriptional Regulator (Drosophila) (SPEN) Interaktionspartner

  1. Spen is required for gene repression by Xist. Spen is not required for Xist RNA localization and the recruitment of chromatin modifications.

  2. Spen is required for Xist-mediated silencing.

  3. results suggest that Xist silences transcription by directly interacting with SHARP, recruiting SMRT, activating HDAC3, and deacetylating histones to exclude Pol II across the X chromosome

  4. MINT forms a high affinity complex with CSL (zeige SMPX Antikörper); the domains of MINT and CSL (zeige SMPX Antikörper) that are necessary and sufficient for complex formation are delineated

  5. MINT plays an important role in tooth development, in particular, epithelial morphogenesis

  6. Notch1 (zeige NOTCH1 Antikörper) in concert with Notch2 (zeige NOTCH2 Antikörper) contributes to the morphogenesis of renal vesicles into S-shaped bodies in a RBP-J (zeige RBPJ Antikörper)-dependent manner.

  7. Msx2-interacting nuclear target protein (MINT) competed with the intracellular region of Notch (zeige NOTCH1 Antikörper) for binding to a DNA binding protein (zeige HSF4 Antikörper) RBP-J (zeige RBPJ Antikörper) and suppressed the transactivation activity of Notch (zeige NOTCH1 Antikörper) signaling.

  8. Stra13, Dec and Sharp (Mint) bHLH repressors are dynamically regulated during mammary gland development and may function to regulate apoptosis

  9. MINT enhances Runx2 (zeige RUNX2 Antikörper) activation of multiprotein complexes assembled by the OCFRE

  10. MINT is involved in CRYBP1 (zeige HIVEP1 Antikörper)-mediated Col2a1 (zeige COL2A1 Antikörper) gene repression and may play a role in regulation of cartilage development

SPEN Antigen-Profil

Protein Überblick

This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator\; this binding can modulate the activity of both liganded and nonliganded steroid receptors.

Genbezeichner und Symbole assoziert mit SPEN

  • spen homolog, transcriptional regulator (Drosophila) (SPEN) Antikörper
  • RNA binding motif protein 15 (RBM15) Antikörper
  • SPEN homolog, transcriptional regulator (Drosophila) (Spen) Antikörper
  • HIAA0929 Antikörper
  • Mint Antikörper
  • mKIAA0929 Antikörper
  • OTT Antikörper
  • OTT1 Antikörper
  • RBM15C Antikörper
  • SHARP Antikörper
  • SPEN Antikörper

Bezeichner auf Proteinebene für SPEN

spen homolog, transcriptional regulator (Drosophila) , SMART/HDAC1 associated repressor protein , RNA-binding motif protein 15 , one twenty two protein , one twenty-two , one-twenty two protein 1 , putative RNA-binding protein 15 , Msx2 interacting nuclear target (MINT) homolog , SMART/HDAC1-associated repressor protein , msx2-interacting protein , nuclear receptor transcription cofactor , Msx2 interacting nuclear target protein

GENE ID SPEZIES
419460 Gallus gallus
64783 Homo sapiens
23013 Homo sapiens
56381 Mus musculus
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