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May have a role in the regulation of spermatogenesis.. Zusätzlich bieten wir Ihnen PD-1 Antikörper (662) und PD-1 Proteine (93) und viele weitere Produktgruppen zu diesem Protein an.
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Human PD-1 ELISA Kit für Sandwich ELISA - ABIN2703394
Yanaba, Hayashi, Yoshihara, Nakagawa: Serum levels of soluble programmed death-1 and programmed death ligand-1 in systemic sclerosis: Association with extent of skin sclerosis. in The Journal of dermatology 2016
results not only provide a foundation for further assessment of PD-L1 (zeige CD274 ELISA Kits) immunohistochemistry as a predictive marker for anti-PD-1 therapy in colorectal carcinoma
Blimp-1 (zeige PRDM1 ELISA Kits) binds to the promoters of PD-1 and TIGIT (zeige TIGIT ELISA Kits) and positively regulates their expression in patients with acute myeloid leukemia (zeige BCL11A ELISA Kits).
high PD-L1 (zeige CD274 ELISA Kits) expression by tumor cells was associated with favorable prognosis, whereas an increased number of PD-1+ TILs was correlated with poor prognosis in thymic carcinoma.
The majority of primary penile penile squamous cell carcinoma (SqCC) tumors express PD-L1 (zeige CD274 ELISA Kits), which is associated with high-risk clinicopathologic features and poor clinical outcome. These data provide a rational basis for further investigation of anti-PD-1 and anti-PD-L1 (zeige CD274 ELISA Kits) immunotherapeutics in patients with advanced penile SqCC
Of several immunotherapies being investigated, antibodies that target the programmed cell death protein-1 (nivolumab and pembrolizumab) and cytotoxic T-lymphocyte antigen-4 (zeige CTLA4 ELISA Kits) (ipilimumab) immune checkpoint pathways are among the most promising for patients with Small cell lung cancer (SCLC), and are the focus of this review.
In this review, we discuss deepening insights into human genetics and our understanding of the interface with rheumatoid arthritis pathogenesis providing a strong rationale for exploiting the co-inhibitory receptor programmed cell death-1 signaling pathway as a better approach for the treatment of this chronic, often progressive destructive joint disease.
PD-L1 (zeige CD274 ELISA Kits) expression was related to a poor prognosis in patients with gastric cancer. Furthermore, PD-1 expression on T-cells was up-regulated in patients with tumors with PD-L1 (zeige CD274 ELISA Kits) expression
PD-1/PD-L1 (zeige CD274 ELISA Kits) inhibitors have produced significant improvements in overall survival compared with single-agent docetaxel delivered in the second-line setting, effectively establishing a new standard of care in non-small cell lung cancer.
Study didn't find any association between PD-1 expression and clinicopathological factors or outcomes in esophageal squamous cell carcinoma.
Data suggest the anti-programmed death-1 (PD-1) antibody pembrolizumab treatment induced favorable responses in a heavily pretreated patient cohort, justifying further studies.
Data (including data from studies in transgenic/knockout mice) suggest that T-cell expression of Mirn155 is required to limit melanoma growth; miR (zeige MLXIP ELISA Kits)-155, Pdcd1, Pdcd1l1 (zeige CD274 ELISA Kits), and Ctla4 (zeige CTLA4 ELISA Kits) appear to regulate overlapping pathways promoting antitumor immunity. [Mirn155 = microRNA 155; Pdcd1 = programmed cell death 1 protein; Pdcd1l1 (zeige CD274 ELISA Kits) = programmed cell death 1 ligand 1 (zeige CD274 ELISA Kits) protein; Ctla4 (zeige CTLA4 ELISA Kits) = cytotoxic T-lymphocyte-associated protein 4 (zeige CTLA4 ELISA Kits)]
PD-1 plays a vital role in brain inflammation via regulation of Fgl-2 (zeige FGL2 ELISA Kits) after ICH (zeige ACE ELISA Kits), and that manipulation of PD-1 might be a promising therapeutical target in ICH (zeige ACE ELISA Kits).
We identified PD-1 to be specifically expressed in PLZF(+) ILCp and revealed that the timing and order of expression of the transcription factors NFIL3 (zeige NFIL3 ELISA Kits), ID2, and TCF-1 (zeige HNF1A ELISA Kits) was critical. Importantly, induction of ILC (zeige CCL27 ELISA Kits) lineage commitment required only transient expression of NFIL3 (zeige NFIL3 ELISA Kits) prior to ID2 and TCF-1 (zeige HNF1A ELISA Kits) expression.
The identification of the role for PD-1 in regulating B cell-dependent antitumor immunity to Tn antigen highlights an opportunity to develop new therapeutic strategies targeting tumor-associated carbohydrate antigens
These findings suggest that PD-1 pathway blockade may reverse adaptive immune resistance following cyclic dinucleotide treatment, enhancing both local and systemic antitumor immunity.
data suggest that increased expression of checkpoint blockade molecules PD-1 and CTLA-4 (zeige CTLA4 ELISA Kits) on donor T cells is not sufficient to prevent GvHD, and that cooperation between checkpoint blockade signaling by host cells and donor Tregs is necessary to limit GvHD in allo-HSCT recipients
PD-1 Blockade Promotes Epitope Spreading in Anticancer CD8 (zeige CD8A ELISA Kits)(+) T Cell Responses by Preventing Fratricidal Death of Subdominant Clones To Relieve Immunodomination
Adoptive transfer of murine T cells expressing a chimeric-PD1-Dap10 (zeige HCST ELISA Kits) receptor may induce a preferential cytokine profile and T-cell differentiation phenotype for anti-lymphoma therapies.
soluble PD-1 is elevated in critical illness and may represent a potential biomarker for Acute respiratory distress syndrome.
Together, our results suggest an important role of PD-1 in glioma-induced immune escape, and provide translational evidence for the use of PD-1 blocking antibodies in human malignant gliomas.
Data show that CTLA-4 (zeige CTLA4 ELISA Kits)(+)PD-1(-) memory CD4 (zeige CD4 ELISA Kits)(+) T cells, which share phenotypic markers with regulatory T cells, were enriched in SIV DNA in blood, lymph nodes (LN), spleen, and gut (zeige GUSB ELISA Kits), and contained replication-competent and infectious virus.
Compared to before immunosuppression, PD-1 expression increased at reactivation. Increased T cells before zoster is likely due to virus reactivation.
A PD-1(high) phenotype is associated with accelerated in vivo CD8 (zeige CD8A ELISA Kits) T cell turnover in SIV-infections, especially within the SIV-specific CD8 (zeige CD8A ELISA Kits) T cell pool.
High levels of PD-1 expression on CD4 (zeige CD4 ELISA Kits)(+) T cells in lymph nodes of rhesus macaques can serve as a valuable marker to identify T follicular helper cells.
Data indicate that PD-1 expression is increased as a result of T cell activation during a primary immune response as well as during persistent immune activation in macaques.
PD-1 can serve as a sensitive indicator of persistent, low-level virus replication
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
programmed cell death protein 1
, protein PD-1
, programmed cell death 1
, programmed death 1