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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Zusätzlich bieten wir Ihnen DNMT3B Kits (11) und DNMT3B Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 132 products:
Human Monoclonal DNMT3B Primary Antibody für ChIP, CyTOF - ABIN252478
Santoro, Li, Grummt: The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. in Nature genetics 2002
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Human Polyclonal DNMT3B Primary Antibody für ICC, IF - ABIN151734
Robert, Morin, Beaulieu, Gauthier, Chute, Barsalou, MacLeod: DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. in Nature genetics 2003
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Human Polyclonal DNMT3B Primary Antibody für IHC (p), WB - ABIN387884
Lu, Markowetz, Unwin, Leek, Airoldi, MacArthur, Lachmann, Rozov, Maayan, Boyer, Troyanskaya, Whetton, Lemischka: Systems-level dynamic analyses of fate change in murine embryonic stem cells. in Nature 2009
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Human Polyclonal DNMT3B Primary Antibody für ChIP, IHC - ABIN152675
Okano, Bell, Haber, Li: DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. in Cell 1999
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Human Monoclonal DNMT3B Primary Antibody für ChIP, WB - ABIN2668954
Castro, Breiling, Luetkenhaus, Ceteci, Hausmann, Kress, Lyko, Rudel, Rapp: MYC-induced epigenetic activation of GATA4 in lung adenocarcinoma. in Molecular cancer research : MCR 2013
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Human Polyclonal DNMT3B Primary Antibody für IF (p), IHC (p) - ABIN727623
Zhao, Hou, Chen, Shao, Zhu, Bu, Gu, Li, Zhang, Du, Fu, Kong, Luo, Long, Li, Deng, Zhao, Cen: Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation. in Neurobiology of disease 2015
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Human Polyclonal DNMT3B Primary Antibody für IF, IHC - ABIN1534163
Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: The DNA sequence and comparative analysis of human chromosome 20. ... in Nature 2002
Human Polyclonal DNMT3B Primary Antibody für EIA, IHC (p) - ABIN356569
Stipani, Cappello, Daddabbo, Natuzzi, Miniero, Stipani, Palmieri: The mitochondrial oxoglutarate carrier: cysteine-scanning mutagenesis of transmembrane domain IV and sensitivity of Cys mutants to sulfhydryl reagents. in Biochemistry 2001
Cow (Bovine) Polyclonal DNMT3B Primary Antibody für WB - ABIN2783648
Boland, Christman: Characterization of Dnmt3b:thymine-DNA glycosylase interaction and stimulation of thymine glycosylase-mediated repair by DNA methyltransferase(s) and RNA. in Journal of molecular biology 2008
dnmt7 specifically methylates no tail gene in the genome
Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (zeige HELLS Antikörper) content are rather a function of time, and not a genetic component.
Overexpression of MAEL (zeige MAEL Antikörper) in UCB cells substantially enhanced the enrichment of DNA methyltrans-ferase (DNMT (zeige DNMT1 Antikörper))3B and histone deacetylase (HDAC)1 (zeige HDAC1 Antikörper)/2 on the promoter of the MTSS1 (zeige MTSS1 Antikörper), and thereby epigenetically suppressing the MTSS1 (zeige MTSS1 Antikörper) transcription.
Data suggest that the overexpression of DNMT3B4 may play an important role in human kidney tumorigenesis through chromosomal instability and methylation of RASSF1A (zeige RASSF1 Antikörper).
MUC1 (zeige MUC1 Antikörper)-C is of functional importance to induction of DNMT1 (zeige DNMT1 Antikörper) and DNMT3b and, in turn, changes in DNA methylation (zeige HELLS Antikörper) patterns in cancer cells.
Dnmt3b plays a tumor suppressive role in MLL (zeige MLL Antikörper)-AF9 (zeige MLLT3 Antikörper) AML (zeige RUNX1 Antikörper) progression
Studies indicate that DNA methylation (zeige HELLS Antikörper) is mediated by three DNA (Cytosine-5-)-Methyltransferase (DNMTs): DNMT1 (zeige DNMT1 Antikörper) is responsible for the maintenance of methylation patterns after DNA replication whereas DNMT3A (zeige DNMT3A Antikörper) and DNMT3B carry out de novo methylation, and DNMT (zeige DNMT1 Antikörper) inhibitors have showed promising results in clinical trials of prostate cancer.
novel functions for Dnmt3a (zeige DNMT3A Antikörper) and Dnmt3b at enhancers that could contribute to their roles in disease and tumorigenesis, are reported.
in HCT116 colorectal cancer cells lacking DNA methyltransferases DNMT1 (zeige DNMT1 Antikörper) or DNMT3B, LCT13 expression decreases, while cells lacking both DNMTs or treated with the DNMT (zeige DNMT1 Antikörper) inhibitor 5-azacytidine (5-aza) show no change in LCT13 expression.
In mammals, DNA methylation (zeige HELLS Antikörper) is introduced by the DNMT1 (zeige DNMT1 Antikörper), DNMT3A (zeige DNMT3A Antikörper), and DNMT3B enzymes, which are all large multi-domain proteins. These enzymes contain a catalytic C-terminal domain with a characteristic cytosine-C5 methyltransferase fold and an N-terminal part with different domains that interacts with other proteins and chromatin and is involved in targeting and regulation of the DNMTs
data indicated that Kaempferol is a novel DNMT3B inhibitor, which may promote the degradation of DNMT3B in bladder cancer.
TLR9 (zeige TLR9 Antikörper) upregulation in cases with episomal HPV16 was again higher among those with non-methylated immunostimulatory CpG motifs. Comparison of cases with HPV-negative controls revealed that DNMT3A (zeige DNMT3A Antikörper) was significantly downregulated only among integrated cases, DNMT3B was significantly overexpressed among both categories of cases, although at variable levels, while DNMT1 (zeige DNMT1 Antikörper) failed to show any deregulated expression among the cases
The epiblast expressed epithelial markers, MUC1 (zeige MUC1 Antikörper) and E-CADHERIN (zeige CDH1 Antikörper), and the pluripotency markers, DNMT3B and CRIPTO (zeige TDGF1 Antikörper).
Developmental changes in expression of DNMT3B are indicative of a possible role in changes in methylation in cattle.
The expression levels of DNMT3a (zeige DNMT3A Antikörper) and DNMT3b were associated with several beef quality traits.
a new paradigm of transcriptional regulation critical for cardiac development and maturation that is controlled by the interaction of REST, DNMT3B and non-CpG methylation.
Together, this study described the regulation of Chk2 (zeige CHEK2 Antikörper) expression through promoter methylation by Dnmt3b and also presented a novel role of Chk2 (zeige CHEK2 Antikörper) during neuronal differentiation, which is independent of its previously known function in DNA damage response.
in mouse embryonic stem cells, Dnmt3b-dependent intragenic DNA methylation protects the gene body from spurious RNA polymerase II entry and cryptic transcription initiation
three DNA methyltransferases, Dnmt1 (zeige DNMT1 Antikörper), Dnmt3a (zeige DNMT3A Antikörper), and Dnmt3b, have been identified. Dnmt3a (zeige DNMT3A Antikörper) and Dnmt3b are responsible for establishing DNA methylation (zeige HELLS Antikörper) patterns produced through their de novo-type DNA methylation (zeige HELLS Antikörper) activity in implantation stage embryos and during germ cell differentiation. Dnmt3-like (Dnmt3l (zeige TRDMT1 Antikörper)), which is a member of the Dnmt3 family but does not possess DNA methylation (zeige HELLS Antikörper)
While lens epithelial cell survival requires DNMT1 (zeige DNMT1 Antikörper), morphologically normal lenses develop in the absence of both DNMT3A (zeige DNMT3A Antikörper) and DNMT3B.
Mechanical stimulation regulates osteoblastic genes expression via direct regulation of Dnmt3b.
a miR (zeige MLXIP Antikörper)-125b-DNMT3b-p53 (zeige TP53 Antikörper) signal pathway may exist in the vascular smooth muscle cells proliferation induced by homocysteine.
miR (zeige MLXIP Antikörper)-29a mimic transfection lowered collagen 1alpha1, DNMT1 (zeige DNMT1 Antikörper), DNMT3b and SET1A (zeige SETD1A Antikörper) expression in hepatic stellate cells.
Loss of DNMT3B results in hypomethylation of the miR (zeige MLXIP Antikörper)-196b promoter and increased miR (zeige MLXIP Antikörper)-196b expression, which directly targets the mTORC2 (zeige CRTC2 Antikörper) component Rictor (zeige RICTOR Antikörper).
The findings define PRMT7 (zeige PRMT7 Antikörper) as a regulator of the DNMT3b/p21 (zeige D4S234E Antikörper) axis required to maintain muscle stem cell regenerative capacity.
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
DNA (cytosine-5)-methyltransferase 3B
, DNA (cytosine-5-)-methyltransferase 3 beta
, DNA cytosine-5 methyltransferase 3 beta
, DNA (cytosine-5)-methyltransferase 3B-like
, DNA methyl transferase beta
, DNA methyltransferase 3B
, DNA MTase HsaIIIB
, DNA methyltransferase HsaIIIB
, DNA (cytosine-5-)-methyltransferase 3 beta, like
, DNA (cytosine-5-)-methyltransferase 7
, DNA MTase MmuIIIB
, DNA methyltransferase MmuIIIB