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F11 encodes coagulation factor XI of the blood coagulation cascade. Zusätzlich bieten wir Ihnen Factor XI Kits (45) und Factor XI Proteine (16) und viele weitere Produktgruppen zu diesem Protein an.
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Three loci showed robust, replicating association with circulating FXI levels: KNG1 (zeige KNG1 Antikörper) (rs710446, P-value = 2.07 x 10-302), F11 (rs4253417, P-value = 2.86 x 10-193), and a novel association in GCKR (zeige GCKR Antikörper) (rs780094, P-value = 3.56 x10-09), here for the first time implicated in FXI regulation. The two first SNPs (rs710446 and rs4253417) also associated with partial thromboplastin (zeige F3 Antikörper) time
The rs710446 and five low-frequency variant sets in KNG1 (zeige KNG1 Antikörper) with FXI level variation of Factor XI were significant after multiple testing correction and permutation.
Exploring the global landscape of genetic variation in coagulation factor XI deficiency
Structures of FXI in complex with the laminin-derived peptide EFPDFP and a DFP (zeige PPCS Antikörper) peptide from the random screen demonstrated binding in the same pocket, although in a slightly different conformation, thus revealing some flexibility in the molecular interactions of the FXI apple 2 domain.
inhibition of FXI and FXII (zeige F12 Antikörper) distinctly alter the biophysical properties of fibrin.
Acute Coronary Syndrome patients had an enhanced prothrombotic profile, demonstrated by an increased thrombin (zeige F2 Antikörper) generation potential, factor XIa and D-dimer levels.
Data show that among the studied polymorphisms, only coagulation factor XI (F11) single nucleotide polymorphism rs2289252 was significantly associated with venous thrombosis (VT) and the F11 rs2289252-A allele was associated with a 1.6-fold increased risk of VT
Thus in conclusion, the bleeding manifestations in FXI deficiency are varied and unpredictable; neither correlates with FXI levels nor with the mutations. Comprehensive analysis of all the factors including both plasma and platelet FXI, global hemostatic factors like thrombin (zeige F2 Antikörper) generation potential may indicate a potential laboratory indicator for FXI deficiency related bleeding manifestations.
Fasudil reduced LPS (zeige IRF6 Antikörper)-mediated TF and PAI-1 (zeige SERPINE1 Antikörper) expression and activity in PBMCs. These effects may partially be relevant to the clinical benefits of fasudil in the treatment of CAPD patients.
High activity of factor XI indicates a risk of occurrence of deep vein thrombosis in post-trauma patients with fractures. F11 rs2089252 and rs2036914 (single nucleotide polymorphisms) are associated with activity of factors XI in such patients despite prophylaxis.
FXI attenuates part of the allergic response to repeated administration of house dust mite in the airways by a mechanism that is independent of activation via FXII (zeige F12 Antikörper).
Thrombin (zeige F2 Antikörper)-independent contribution of tissue factor (zeige F3 Antikörper) to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease.
FXI deprivation was shown to slow down atherogenesis in Apoe (zeige APOE Antikörper) knockout mice.
anion-binding sites on FXIa that are required for expression of heparin's cofactor activity during protease inhibition by antithrombin (zeige SERPINC1 Antikörper) are also required for expression of polyP cofactor activity during FXI activation
Data conclude that within the mouse F11, Klkb1 (zeige KLKB1 Antikörper), Cyp4v3 (zeige CYP4V2 Antikörper) gene cluster, F11 and Cyp4v3 (zeige CYP4V2 Antikörper) frequently display striking parallel transcriptional responses suggesting the presence of shared regulatory elements.
Studies indicate that targeting factor XI (FXI) by knocking out the gene prevents arterial and vein thrombosis.
Protective roles for fibrin, tissue factor (zeige F3 Antikörper), plasminogen activator inhibitor-1 (zeige SERPINE1 Antikörper), and thrombin activatable fibrinolysis inhibitor (zeige CPB2 Antikörper), but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica.
fXI and fXII (zeige F12 Antikörper) contribute to thrombus formation even when factor VIIa/tissue factor (zeige F3 Antikörper) initiates thrombosis.
Gene targeting of tissue factor (zeige F3 Antikörper), factor X, and factor VII (zeige TH Antikörper) in mice: their involvement in embryonic development
FXI is essential for thrombus formation following FeCl3-induced injury of the carotid artery in the mouse.
Sequence analysis of the bovine coagulation factor XI (F11) gene revealed an unusually high number of non-synonymous mutations. However, none of the mutations in the F11 gene were concordant with Bovine neonatal pancytopenia status.
Insertion of 15 nucleotides in the F11 gene is the causative mutation for factor XI deficiency in Japanese black cattle.
The molecular basis of coagulopathy has been recognized in Holstein cattle as a 76-bp insertion in the coding region of the FXI gene
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
coagulation factor XI (plasma thromboplastin antecedent)
, platelet coagulation factor XI
, coagulation factor XI
, coagulation factor XI-like
, plasma thromboplastin antecedent
, factor XI
, blood coagulation factor XI