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Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Zusätzlich bieten wir Ihnen PD-L1 Proteine (83) und PD-L1 Kits (53) und viele weitere Produktgruppen zu diesem Protein an.
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Mouse (Murine) Polyclonal PD-L1 Primary Antibody für CyTOF, FACS - ABIN4899388
Wang, Yoshida, Nakaki, Hiai, Okazaki, Honjo: Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes. in Proceedings of the National Academy of Sciences of the United States of America 2005
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Human Monoclonal PD-L1 Primary Antibody für FACS, IHC (p) - ABIN1449244
Mandavilli: Hormone in the hot seat. in Nature medicine 2006
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Human Polyclonal PD-L1 Primary Antibody für ELISA, FACS - ABIN4282770
Aguilar, Shirley, Chung, Marsh, Walker, Coyle, Marx, Bekaii-Saab, Lesinski, Swanson, Sanchez, Manzanera, Aguilar-Cordova, Bloomston: Gene-mediated cytotoxic immunotherapy as adjuvant to surgery or chemoradiation for pancreatic adenocarcinoma. in Cancer immunology, immunotherapy : CII 2015
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Human Polyclonal PD-L1 Primary Antibody für IHC, ELISA - ABIN1002984
Holling, Schooten, van Den Elsen: Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. in Human immunology 2004
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Human Monoclonal PD-L1 Primary Antibody für IHC (p), ELISA - ABIN1995635
Soliman, Khalil, Antonia: PD-L1 expression is increased in a subset of basal type breast cancer cells. in PLoS ONE 2014
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Human Polyclonal PD-L1 Primary Antibody für IHC (p), WB - ABIN2479616
Ishida, Agata, Shibahara, Honjo: Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. in The EMBO journal 1992
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Human Polyclonal PD-L1 Primary Antibody für IHC, ELISA - ABIN1031034
Angell, Lechner, Jang, Correa, LoPresti, Epstein: BRAF(V600E) in Papillary Thyroid Carcinoma is Associated with Increased Programmed Death Ligand 1 Expression and Suppressive Immune Cell Infiltration. in Thyroid : official journal of the American Thyroid Association 2014
Human Monoclonal PD-L1 Primary Antibody für FACS - ABIN4896033
Nicolazzo, Raimondi, Mancini, Caponnetto, Gradilone, Gandini, Mastromartino, Del Bene, Prete, Longo, Cortesi, Gazzaniga: Monitoring PD-L1 positive circulating tumor cells in non-small cell lung cancer patients treated with the PD-1 inhibitor Nivolumab. in Scientific reports 2016
Human Monoclonal PD-L1 Primary Antibody für CyTOF, FACS - ABIN4899390
Rojas, Krishnan: IFN-gamma generates maturation-arrested dendritic cells that induce T cell hyporesponsiveness independent of Foxp3+ T-regulatory cell generation. in Immunology letters 2010
B7-H1 induction in keratinocytes may play a crucial role in the protection from CD4 (zeige CD4 Antikörper)+ T cell-mediated tissue inflammation by exogenous antigens delivered from the mucosal surface in oral cavity
Interferon (zeige IFNA Antikörper)-related secretome from direct interaction between immune cells and tumor cells is required for upregulation of PD-L1 in tumor cells.
RAS signaling can upregulate tumor cell PD-L1 expression through a mechanism involving increases in PD-L1 mRNA stability via modulation of the AU-rich element-binding protein tristetraprolin (zeige ZFP36 Antikörper).
Data (including data from studies in transgenic/knockout mice) suggest that T-cell expression of Mirn155 is required to limit melanoma growth; miR (zeige MLXIP Antikörper)-155, Pdcd1 (zeige PDCD1 Antikörper), Pdcd1l1, and Ctla4 (zeige CTLA4 Antikörper) appear to regulate overlapping pathways promoting antitumor immunity. [Mirn155 = microRNA 155; Pdcd1 (zeige PDCD1 Antikörper) = programmed cell death 1 (zeige PDCD1 Antikörper) protein; Pdcd1l1 = programmed cell death 1 ligand 1 protein; Ctla4 (zeige CTLA4 Antikörper) = cytotoxic T-lymphocyte-associated protein 4 (zeige CTLA4 Antikörper)]
Expression of LAP/TGF-beta1 (zeige TGFB1 Antikörper), CD80 (zeige CD80 Antikörper), CD86 (zeige CD86 Antikörper) and PD-L1 is significantly increased in tumor-infiltrating B cells (TIL (zeige TLR1 Antikörper)-B) relative to splenic B cells. LAP/TGF-beta1 (zeige TGFB1 Antikörper) expression on TIL (zeige TLR1 Antikörper)-B progressively increased from 5.4+/-1.7% on day 8 to 43.1+/-6.1% by day 21 post tumor implantation.
spleen-derived IFN-gamma (zeige IFNG Antikörper) induces generation of PD-L1(+)-suppressive neutrophils.
PD-L1 and PD-L2 (zeige PDCD1LG2 Antikörper) in dermal fibroblasts is up-regulated by activated T cells in alopecia areata-affected skin.
It was concluded that down-regulated expression of miR (zeige MLXIP Antikörper)-143 and up-regulation of its direct target B7H1 may indicate a novel therapeutic method for radiation-induced thymic lymphoma by increased expression of miR (zeige MLXIP Antikörper)-143 or inhibition of B7H1.
HDAC6 (zeige HDAC6 Antikörper) inhibition reduces tumor growth and PD-L1 production in vivo.
findings indicate that the PerC (zeige PPARGC1B Antikörper) B cells, including PD-L1/PD-L2 (zeige PDCD1LG2 Antikörper) B-1a cells, may suppress T cells responding to allostimulation, and thus may be optimal for donor lymphocyte injection
The presence of PD-L1 expression in association with immune-infiltrating cells and HLA class I (zeige MICA Antikörper) expression in nearly 50% of the dedifferentiated chondrosarcomas provides rationale for including these patients in clinical trials with PD-1 (zeige PDCD1 Antikörper)/PD-L1-targeted therapies.
Paired Comparison of PD-L1 Expression on Cytologic and Histologic Specimens From Malignancies in the Lung Assessed With PD-L1 IHC 28-8pharmDx and PD-L1 IHC 22C3pharmDx.
PD-L1 was found variably expressed in the cytoplasm and the cell surface of both HO8910 and SKOV3 cells. TAM (zeige CCNA1 Antikörper) or IFN-gamma (zeige IFNG Antikörper), TNF-alpha (zeige TNF Antikörper), IL-10 (zeige IL10 Antikörper) and IL-6 (zeige IL6 Antikörper) released from TAM (zeige CCNA1 Antikörper) stimulated the expression of PD-L1 at the surface of the cancer cells. The IHC results were consistent with the data in vitro showing infiltration of TAM (zeige CCNA1 Antikörper) correlated with membranous PD-L1.
Results showed that PD-L1 expression on solid tumor cells was upregulated by IFNG (zeige IFNG Antikörper) mainly through JAK (zeige JAK3 Antikörper)-STAT (zeige STAT1 Antikörper) pathway and membranous PD-L1 expression on tumor cells in the tumor microenvironment of gastric cancer was significantly positively correlated with tumor stroma CD8 (zeige CD8A Antikörper)-positive T cells and tumor IFNG (zeige IFNG Antikörper) levels.
PD-L1 expression in provides normally immunogenic colorectal carcinoma a means of immune evasion and a more aggressive biology.
Data suggest that TNFalpha (zeige TNF Antikörper) and IFNgamma synergistically induce PDL1 expression in dermal lymphatic endothelial cells; in this process, expression of microRNA-155 is up-regulated; PDL1 3prime-untranslated region contains two functional microRNA-155 binding sites/response elements. (PDL1 = programmed death ligand-1 protein; IFNgamma = interferon-gamma (zeige IFNG Antikörper); TNFalpha (zeige TNF Antikörper) = tumor necrosis factor-alpha (zeige TNF Antikörper))
Data suggest that hormonal 1,25-dihydroxyvitamin D is a direct transcriptional inducer of genes encoding PDL1 and PDL2 (zeige PDCD1LG2 Antikörper) in myeloid cells/macrophages; this up-regulation of gene expression appears to be species- and cells-specific.
CMTM6 (zeige CMTM6 Antikörper) is present at the cell surface, associates with the PD-L1 protein, reduces its ubiquitination and increases PD-L1 protein half-life; CMTM6 (zeige CMTM6 Antikörper) enhances the ability of PD-L1-expressing tumour cells to inhibit T cells; collectively, our data reveal that PD-L1 relies on CMTM6 (zeige CMTM6 Antikörper)/4 to efficiently carry out its inhibitory function, and suggest potential new avenues to block this pathway
CMTM6 (zeige CMTM6 Antikörper) depletion, via the reduction of PD-L1, significantly alleviates the suppression of tumour-specific T cell activity in vitro and in vivo; findings provide insights into the biology of PD-L1 regulation, identify a previously unrecognized master regulator of this critical immune checkpoint and highlight a potential therapeutic target to overcome immune evasion by tumour cells
PD-L1 underexpression is associated with gastric cancer.
These results suggest that the soluble recombinant proteins may be used to prepare monoclonal antibodies to block the PD-1 (zeige PDCD1 Antikörper)/PD-L1 pathway.
role of programmed death ligand-1 (PD-L1) during porcine circovirus type 2 (PCV2) infection and porcine circovirus associated diseases (PCVAD) development
These data suggest that overexpression of PD-L1 and PD-L2 (zeige PDCD1LG2 Antikörper) mRNA is one mechanism by which immunosupression of postweaning multisystemic wasting syndrome pigs occurs.
Retinal PLD1 expression is enhanced in radial fibers of Muller cells with age. This finding suggests that PLD1 plays an important role in signal transduction of glial cells and neuronal cells in the retina.
A porcine PD-L1 molecule was cloned using RACE (rapid amplification of cDNA ends) technology and sequenced (GenBank # AY837780); it showed high sequence homology with human PD-L1.
This study provides novel information for the understanding of signalling through PD-L1.
Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
, CD274 antigen
, programmed cell death 1 ligand 1
, programmed cell death ligand 1
, B7 homolog 1
, PDCD1 ligand 1
, programmed death ligand 1