anti-WEE1 (WEE1) Antikörper

Auf www.antikoerper-online.de finden Sie aktuell 156 WEE1 Homolog (S. Pombe) (WEE1) Antikörper von 18 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen WEE1 Proteine (9) und WEE1 Kits (5) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 182 WEE1 Produkte verfügbar.
Synonyme:
ATWEE1, F22D16.3, F22D16_3, GB19689, wee1, WEE1 kinase homolog, WEE1-KINASE, WEE1A, wee1b, WEE1hu, xwee1, xwee2
Alle Antikörper anzeigen Gen GeneID UniProt
WEE1 308937 Q63802
WEE1 22390 P47810
WEE1 7465 P30291

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anti-Human WEE1 Antikörper:

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Weitere Antikörper gegen WEE1 Interaktionspartner

Mouse (Murine) WEE1 Homolog (S. Pombe) (WEE1) Interaktionspartner

  1. Morphine significantly downregulated the expression of miRNA-219-5p, which targets WEE1 to suppress Tyr15 expressions and activate Cdc2 (zeige CDK1 Antikörper), thus inhibiting the morphine-induced macrophage apoptosis.

  2. Results revealed that WEE1 is indispensable for maintaining genomic stability and it functions as a haploinsufficient tumor suppressor.

  3. Wee1 is directly or indirectly involved in the mechanism of the circadian rhythm-dependent changes in docetaxel-induced intestinal damage.

  4. The induction of Wee1 under hypoxia was confirmed both at the mRNA and protein levels.

  5. In this study, we found that the chromosomal wee1 gene is also down-regulated by KLF3 (zeige KLF3 Antikörper).

  6. The regulation of Wee1 by SadA (zeige BRSK2 Antikörper) and SadB (zeige BRSK1 Antikörper) kinases is essential for the differentiation of polarized neurons.

  7. Mammalian Wee1 plays a critical role in maintaining genome integrity and is essential for embryonic survival at the pre-implantation stage of mouse development.

  8. expression of wee1 was directly regulated by the molecular components of the circadian clockwork in the regenerating liver

  9. transcription repressive activity of TBP-related factor 2 (zeige TBPL1 Antikörper) to wee1 promoter needs association with the promoter and TFIIA (zeige GTF2A1 Antikörper)

  10. the suppression of nuclear import of cyclin B1 (zeige CCNB1 Antikörper), the induction of Wee1 kinase activity, and the transient nuclear accumulation of p21(CIP1/WAF1 (zeige CDKN1A Antikörper)) may play important roles in the transient cell cycle delay in response to ionizing radiation

Human WEE1 Homolog (S. Pombe) (WEE1) Interaktionspartner

  1. Data suggest that SMURF1 (zeige SMURF1 Antikörper) is required for S phase progression; SMURF1 (zeige SMURF1 Antikörper) promotes ubiquitination-dependent degradation of WEE1; these functions of SMURF1 (zeige SMURF1 Antikörper) appear to be linked and may be important in cell proliferation and tumorigenesis. (SMURF1 (zeige SMURF1 Antikörper) = SMAD specific E3 ubiquitin protein ligase 1 (zeige SMURF1 Antikörper); WEE1 = wee 1 homolog [S pombe] protein)

  2. Date show that when Wee1 alone is inhibited, Chk1 (zeige CHEK1 Antikörper) suppresses CDC45 (zeige CDC45 Antikörper) loading and thereby limits the extent of unscheduled replication initiation and subsequent S-phase DNA damage, despite very high CDK (zeige CDK4 Antikörper)-activity.

  3. we overexpressed CKS1B (zeige CKS1B Antikörper) in multiple cell lines and found increased sensitivity to PLK1 (zeige PLK1 Antikörper) knockdown and PLK1 (zeige PLK1 Antikörper) drug inhibition. Finally, combined inhibition of WEE1 and PLK1 (zeige PLK1 Antikörper) results in less apoptosis than predicted based on an additive model of the individual inhibitors, showing an epistatic interaction and confirming a prediction of the yeast data.

  4. Wee1 staining intensity was a predictor of favorable metastasis-free and overall survival compared to strong intensity and no or weak staining

  5. These results highlight the key role of WEE1 suppression to combat glioblastomas. Moreover, it showed beneficial possibilities of WEE1 suppression with different anticancer approaches for neurological malignancies.

  6. Wee1 inhibition potentiates Wip1-dependent tumor sensitization effect by reducing levels of Hipk2 kinase, a negative regulator of Wip1 pathway.

  7. High nuclear expression of WEE1 protein is associated with all glioma grades and types.

  8. Consistent with these findings, a genome-scale pooled RNA interference screen revealed that toxic doses of MK-1775 are suppressed by CDK2 (zeige CDK2 Antikörper) or Cyclin A2 (zeige CCNA2 Antikörper) knockdown. These findings support G2 exit as the more significant effect of Wee1 inhibition in pancreatic cancers.

  9. WEE1 is regulated at the translational level by CPEB1 (zeige CPEB1 Antikörper) and miR (zeige MLXIP Antikörper)-15b in a coordinated and cell-cycle-dependent manner.

  10. Data show that proto-oncogene (zeige RAB1A Antikörper) protein Mdm2 (zeige MDM2 Antikörper) inactivation successfully protects tumor suppressor protein (p53 (zeige TP53 Antikörper))-proficient cells against the cytotoxic effects of Wee1 protein inhibition.

Arabidopsis thaliana WEE1 Homolog (S. Pombe) (WEE1) Interaktionspartner

  1. the identification of a second member of the RNase H2 complex, RNase H2B (zeige RNASEH2B Antikörper), being able to complement the root growth phenotype of WEE1(KO) plants, is reported.

  2. mutant alleles of the genes encoding subunits of the ribonuclease H2 (RNase H2) complex, known for its role in removing ribonucleotides from DNA-RNA duplexes, were identified as suppressor mutants of WEE1 knockout plants.

  3. The plant WEE1 kinase acquired an indirect developmental function that is important for meristem maintenance upon replication stress.

  4. The WEE1 gene is not rate-limiting for cell cycle progression under normal growth conditions but is a critical target of the ATR (zeige ATR Antikörper)-ATM (zeige ATM Antikörper) signaling cascades that inhibit the cell cycle upon activation of the DNA integrity checkpoints.

WEE1 Antigen-Profil

Beschreibung des Gens

This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.

Alternative names and synonyms associated with WEE1

  • WEE1 homolog (S. pombe) (WEE1) Antikörper
  • WEE1 homolog 2 (wee2) Antikörper
  • Wee1 kinase (Wee1) Antikörper
  • Wee1-like protein kinase (wee) Antikörper
  • wee 1 homolog (S. pombe) (Wee1) Antikörper
  • WEE 1 homolog 1 (S. pombe) (Wee1) Antikörper
  • Wee1-like protein kinase (WEE1) Antikörper
  • ATWEE1 Antikörper
  • F22D16.3 Antikörper
  • F22D16_3 Antikörper
  • GB19689 Antikörper
  • wee1 Antikörper
  • WEE1 kinase homolog Antikörper
  • WEE1-KINASE Antikörper
  • WEE1A Antikörper
  • wee1b Antikörper
  • WEE1hu Antikörper
  • xwee1 Antikörper
  • xwee2 Antikörper

Bezeichner auf Proteinebene für WEE1

WEE1 homolog (S. pombe) , wee1-like protein kinase 2 , Wee1 kinase , Wee1-like protein kinase , wee1 tyrosine kinase , wee1-like protein kinase , wee1A kinase , WEE1 tyrosine kinase , WEE1+ homolog

GENE ID SPEZIES
100071182 Equus caballus
100125126 Xenopus (Silurana) tropicalis
100544287 Meleagris gallopavo
5895039 Monosiga brevicollis MX1
551677 Apis mellifera
308937 Rattus norvegicus
22390 Mus musculus
7465 Homo sapiens
100345730 Oryctolagus cuniculus
423045 Gallus gallus
476847 Canis lupus familiaris
100521487 Sus scrofa
540322 Bos taurus
839453 Arabidopsis thaliana
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