p130 Proteine (RBL2)

Bezeichnung:
Retinoblastoma-Like 2 (p130) Proteine (RBL2)
Auf www.antikoerper-online.de finden Sie aktuell 4 Retinoblastoma-Like 2 (p130) (RBL2) Proteine von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen p130 Antikörper (96) und p130 Kits (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 108 p130 Produkte verfügbar.
Synonyme:
P130, PRB2, Rb2, RBL2, RBR-2, RBR2, RRB2a
alle Proteine anzeigen Gen GeneID UniProt
RBL2 19651 Q64700
Ratte RBL2 RBL2 81758 O55081
RBL2 5934 Q08999

Weitere Synonyme anzeigen

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Weitere Proteine zu p130 Interaktionspartnern

Mouse (Murine) Retinoblastoma-Like 2 (p130) (RBL2) Interaktionspartner

  1. Deletion of Rb or p130 leads to impaired repression of Sox2 (zeige SOX2 Proteine), a defect amplified by inactivation of p53 (zeige TP53 Proteine). Identify binding of pRb (zeige PGR Proteine) and p130 to an enhancer with crucial regulatory activity on Sox2 (zeige SOX2 Proteine) expression.

  2. In skeletal dysplasias cell cycle progression is compromised in the G1 phase due to reduced phosphorylation of the pocket protein p130 leading to inhibition of transcription factors of the E2F (zeige E2F1 Proteine) family.

  3. Following stress exposure, E2F4 (zeige E2F4 Proteine)-p130 complexes are lost rapidly along with the presence of E2F4 (zeige E2F4 Proteine) at E2F (zeige E2F1 Proteine)-containing B-Myb (zeige MYBL2 Proteine) promoter sites.

  4. PRMT5 (zeige PRMT5 Proteine) knockdown in non-Hodgkin lymphoma cell lines and primary lymphoma cells leads to RBL2 derepression and RB1 (zeige RB1 Proteine) reactivation, which in turn inhibit PRC2 expression.

  5. Rb, p107 (zeige RBL1 Proteine) and p130 epigenetically protect newly born cortical neurons from DNA damage and cell division

  6. The balance between phosphorylation and acetylation of Rb2/p130 is essential for its biological function in cell cycle control.

  7. Rb2 coimmunolocalizes with the chromatin insulator CCCTC-binding factor (CTCF (zeige CTCF Proteine)) and BORIS (zeige CTCFL Proteine) in T-antigen-positive but not in T-antigen-negative cells.

  8. Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) and pRb (zeige PGR Proteine) signal pathways interact with each other and form common p130/Gsk3beta/beta-catenin (zeige CTNNB1 Proteine) complex during MSC (zeige MSC Proteine) cycle progression.

  9. Mutation of p107 (zeige RBL1 Proteine) or p130 reduces survival of Rb-deficient myoblasts during differentiation.

  10. Gsk3beta, p130 and beta-catenin (zeige CTNNB1 Proteine) form in MSC (zeige MSC Proteine) a complex the functional role of which may be associated with activation of differentiation not coupled to cell cycle arrest.

Human Retinoblastoma-Like 2 (p130) (RBL2) Interaktionspartner

  1. UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 (zeige RBL1 Proteine) and p130 proteins

  2. Hepatitis C virus core protein modulates pRb2/p130 expression in human hepatocellular carcinoma cell lines through promoter methylation

  3. Statistical analysis revealed that Rbl2/p130 expression negatively correlates to its promoter methylation (r = -0.412) in tumor tissues.

  4. TGF-beta (zeige TGFB1 Proteine) induced RBL2 expression through down-regulating miR (zeige MLXIP Proteine)-93 in renal cancer cells

  5. the inactivation of RB1 (zeige RB1 Proteine) or RB2/P130 in uncommitted bone marrow stromal cells facilitates the first steps of adipogenesis.

  6. expression profiling of miRNAs in high-grade serous ovarian carcinoma indicated miR (zeige MLXIP Proteine)-106a and its family members were upregulated; findings suggest miR (zeige MLXIP Proteine)-106a can repress expression of the retinoblastoma family member RBL2 and miR (zeige MLXIP Proteine)-106a overexpression results in rapid tumor growth and poor differentiation

  7. PRMT5 (zeige PRMT5 Proteine) knockdown in non-Hodgkin lymphoma cell lines and primary lymphoma cells leads to RBL2 derepression and RB1 (zeige RB1 Proteine) reactivation, which in turn inhibit PRC2 expression.

  8. Low expression of RBL2 is associated with glioma.

  9. Silencing of RB1 (zeige RB1 Proteine) but not RB2/P130 decreases proliferative activity and impairs the differentiation potential of human mesenchymal stem cells.

  10. Our hypothesis not only enrich the knowledge of the regulation of ALT, but also indicate that p130 may serve as a potential suppressor of ALT, and gene therapy of p130 may be used in cervical cancers.

p130 (RBL2) Protein Überblick

Protein Überblick

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Alternative names and synonyms associated with p130 (RBL2)

  • retinoblastoma-like 2 (p130) (RBL2)
  • related to retinoblastoma2 (rrb2)
  • retinoblastoma-like 2 (Rbl2)
  • P130 Protein
  • PRB2 Protein
  • Rb2 Protein
  • RBL2 Protein
  • RBR-2 Protein
  • RBR2 Protein
  • RRB2a Protein

Bezeichner auf Proteinebene für RBL2

retinoblastoma-like 2 (p130) , retinoblastoma-like protein 2 , retinoblastoma-like protein 2-like , CL1187_-3 , CL1187_-3(342) , CL1187_-3_ov , PZA00193 , RB , RRB2b , Retinoblastoma-related protein 2 , nPZA00193.2 , retinoblastoma-related protein 2a , 130 kDa retinoblastoma-associated protein , retinoblastoma-related protein 2 , P130 , PPAR-alpha-interacting complex protein 128 , PRB2 , PRIC128 , RBR-2

GENE ID SPEZIES
415721 Gallus gallus
467978 Pan troglodytes
478127 Canis lupus familiaris
533294 Bos taurus
100019136 Monodelphis domestica
100410298 Callithrix jacchus
100547227 Meleagris gallopavo
541652 Zea mays
19651 Mus musculus
81758 Rattus norvegicus
5934 Homo sapiens
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