anti-MYBL2 (MYBL2) Antikörper

Auf finden Sie aktuell 108 V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2) Antikörper von 20 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MYBL2 Kits (8) und MYBL2 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 132 MYBL2 Produkte verfügbar.
B-MYB, BMYB, myb1, MYBL2
Alle Antikörper anzeigen Gen GeneID UniProt
MYBL2 296344  
MYBL2 17865 P48972
MYBL2 4605 P10244

Meistgesuchte Reaktivitäten zu anti-MYBL2 (MYBL2) Antikörper

anti-Rat (Rattus) MYBL2 Antikörper:

anti-Mouse (Murine) MYBL2 Antikörper:

anti-Human MYBL2 Antikörper:

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Weitere Antikörper gegen MYBL2 Interaktionspartner

Zebrafish V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2) Interaktionspartner

  1. loss-of-function mutation (crb) in bmyb causes defects in mitotic progression and spindle formation and genome instability in embryos, and cancer susceptibility in adult crb heterozygotes

Mouse (Murine) V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2) Interaktionspartner

  1. Downregulation of B-myb induced senescence by upregulation of p22(phox (zeige CYBA Antikörper)) and activation of the ROS (zeige ROS1 Antikörper)/p53 (zeige TP53 Antikörper)/p21 (zeige D4S234E Antikörper) pathway

  2. B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development.

  3. MYBL2 haploinsufficiency increases susceptibility to age-related haematopoietic neoplasia.

  4. Results coupled with functional studies demonstrate that B-MYB not only controls and accelerates cell cycle progression in ESCs (zeige NR2E3 Antikörper) it contributes to fate decisions and maintenance of pluripotent stem cell identity.

  5. Our data suggest that B-Myb is required as a pioneer factor to enable FoxM1 (zeige FOXM1 Antikörper) binding to G2/M gene promoters and explains how these transcription factors may collaborate to induce mitosis.

  6. Mybl2 upregulation induces fast growth and progression of premalignant and malignant liver, through cell cycle deregulation and activation of genes and pathways related to tumor progression.

  7. The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT.

  8. Results describe the characterization of a corepressor site (downstream repression site (DRS (zeige SRPX Antikörper))) required for transcriptional regulation of the B-myb (MybL2 gene) promoter.

  9. B-Myb repressor function is regulated by cyclin A phosph (zeige CCNA2 Antikörper)orylation and sequences within the C-terminal domain.

  10. B-Myb has a role in regulation of c-Myc (zeige MYC Antikörper) expression by cytosolic phospholipase A2 (zeige PLA2G4A Antikörper)

Human V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2) Interaktionspartner

  1. Results suggested that the oncogenic transcription factor HIF-2alpha (zeige EPAS1 Antikörper) stabilized VHL (zeige VHL Antikörper) disease suppressor B-Myb, which is also a transcription factor, by physical interaction. Some B-Myb-dependent gene expression was similarly affected by B-Myb or HIF-2alpha (zeige EPAS1 Antikörper) knockdown, suggesting that stabilization of B-Myb by HIF-2alpha (zeige EPAS1 Antikörper) may play a role in specific gene expressions.

  2. The MuvB multiprotein complex, together with B-MYB and FOXM1 (zeige FOXM1 Antikörper) (MMB-FOXM1 (zeige FOXM1 Antikörper)) regulate the expression of mitotic kinesins in breast cancer cells.

  3. MYBL2 overexpression promotes Gallbladder Cancer cell proliferation through the regulation of the cell cycle at the S and G2/M phase transitions. Thus, MYBL2 could serve as a potential prognostic and therapeutic biomarker in Gallbladder Cancer patients.

  4. Study identified B-Myb as a substrate of the pVHL (zeige VHL Antikörper) ubiquitin ligase complex, which targets it for degradation via the ubiquitin-proteasome pathway. It also, provide evidence that the regulation of B-Myb by pVHL (zeige VHL Antikörper) plays a critical role in von Hippel-Lindau disease.

  5. Data indicate that gene expression alterations in endometrial carcinoma samples with high ATAD2 (zeige ATAD2 Antikörper) expression showed upregulation of several cancer-related genes including B-MYB gene.

  6. We found that B-Myb upregulated expression of the key epithelial-to-mesenchymal transition regulator snail (zeige SNAI1 Antikörper) and that it mediated epithelial-to-mesenchymal transition activation and cell invasion by B-Myb.

  7. conclude that downregulation of MYBL2 activity below levels predicted by classical haploinsufficiency underlies the clonal expansion of hematopoietic progenitors in a large fraction of human myeloid malignancies

  8. Suggest B-myb had critical roles in both cell cycle progression and tumorigenesis in breast cancer.

  9. B-Myb plays a role in suppression of keratinocyte differentiation and maintenance of the undifferentiated proliferative phenotype by modulating the expression levels of cell cycle regulatory proteins, expressed in the S and G2/M phases of the cell cycle

  10. Results show that E7 interacts with the B-Myb, FoxM1 (zeige FOXM1 Antikörper) and LIN9 (zeige LIN9 Antikörper) components of this activator complex, leading to cooperative transcriptional activation of mitotic genes in primary cells and E7 recruitment to the corresponding promoters.

Cow (Bovine) V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2) Interaktionspartner

  1. B-Myb (MYBL2)repressor function is regulated by cyclin A (zeige CCNA2 Antikörper) phosphorylation and sequences within the C-terminal domain.

  2. B-Myb represses SMC (zeige DYM Antikörper) elastin (zeige ELN Antikörper) gene expression and cyclin A (zeige CCNA2 Antikörper) plays a role in the developmental regulation of elastin (zeige ELN Antikörper) gene expression in the aorta

MYBL2 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.

Alternative names and synonyms associated with MYBL2

  • v-myb myeloblastosis viral oncogene homolog (avian)-like 2 (MYBL2) Antikörper
  • v-myb myeloblastosis viral oncogene homolog-like 2 (mybl2) Antikörper
  • myeloblastosis oncogene-like 2 (mybl2) Antikörper
  • myeloblastosis oncogene-like 2 (Mybl2) Antikörper
  • v-myb avian myeloblastosis viral oncogene homolog-like 2 (MYBL2) Antikörper
  • v-myb avian myeloblastosis viral oncogene homolog-like 2 (mybl2) Antikörper
  • v-myb myeloblastosis viral oncogene homolog-like 2 (MYBL2) Antikörper
  • B-MYB Antikörper
  • BMYB Antikörper
  • myb1 Antikörper
  • MYBL2 Antikörper

Bezeichner auf Proteinebene für MYBL2

v-myb myeloblastosis viral oncogene homolog (avian)-like 2 , myb-related protein B , v-myb myeloblastosis viral oncogene homolog-like 2 , MOL2 , b-myb , crash&burn , crb , myb-like protein 2 , B-Myb , XMYB1 , myb-related protein 1 , myeloblastosis oncogene-like 2

458262 Pan troglodytes
694693 Macaca mulatta
100070694 Equus caballus
100126220 Xenopus (Silurana) tropicalis
445390 Danio rerio
296344 Rattus norvegicus
17865 Mus musculus
4605 Homo sapiens
398085 Xenopus laevis
477232 Canis lupus familiaris
510420 Bos taurus
396258 Gallus gallus
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