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Human FOXO3 Protein expressed in HEK-293 Cells - ABIN2712289
Thompson, Larson, Vidrine, Barrios, Navarro, Meyers, Simms, Prajapati, Chitsike, Hellman, Baker, Watkins: FOXO3-NF-κB RelA Protein Complexes Reduce Proinflammatory Cell Signaling and Function. in Journal of immunology (Baltimore, Md. : 1950) 2015
Human FOXO3 Protein expressed in HEK-293 Cells - ABIN2721367
Nott, Cheng, Gao, Lin, Gjoneska, Ko, Minhas, Zamudio, Meng, Zhang, Jin, Tsai: Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior. in Nature neuroscience 2016
by modulating hypoxia-inducible factor activity via up-regulation of VHL (zeige VHL Proteine), FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.
This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.
NOTCH1 (zeige NOTCH1 Proteine) inhibits activation of ATM (zeige ATM Proteine) by impairing the formation of an ATM (zeige ATM Proteine)-FOXO3a-KAT5 (zeige KAT5 Proteine) complex.
FOXO3 is required to induce autophagy and thereby reduce elevated reactive oxygen species levels.
A total of 41 differentially expressed genes, such as SOCS3 (zeige SOCS3 Proteine), VAPA (zeige VAPA Proteine), and COL5A2 (zeige COL5A2 Proteine), are speculated to have roles in the pathogenesis of acute myocardial infarction; 2 transcription factors FOXO3 and MYBL2 (zeige MYBL2 Proteine), and 2 miRNAs hsa (zeige CD24 Proteine)-miR (zeige MLXIP Proteine)-21-5p and hsa (zeige CD24 Proteine)-miR (zeige MLXIP Proteine)-30c-5p may be involved in the regulation of the expression of these differentially expressed genes.
Downregulation of PKC (zeige PRRT2 Proteine) induces senescence through the AKT (zeige AKT1 Proteine)-FoxO3a-ROS (zeige ROS1 Proteine)-p53 (zeige TP53 Proteine)-p21(Cip1/WAF1 (zeige CDKN1A Proteine)) pathway in HCT116 and HEK293 cells.
we demonstrated that REP1 blocked the nuclear trans-localization of FOXO3 through physically interacting with FOXO3, thereby suppressing FOXO3-mediated apoptosis. Importantly, the inhibition of REP1 combined with 5-FU treatment could lead to significant retarded tumor growth in a xenograft tumor model of human cancer cells
TLR4 (zeige TLR4 Proteine) and C5aR (zeige C5AR1 Proteine) crosstalk in dendritic cells induces a core regulatory network of RSK2 (zeige RPS6KA3 Proteine), PI3Kbeta, SGK1 (zeige SGK1 Proteine), and FOXO transcription factors.
FoxO3a is an early stress response protein to glucose toxicity in diabetic conditions.
In cigarette smoke extract stimulated bronchial epithelial cells, carbocysteine increased cell proliferation, and SIRT1 (zeige SIRT1 Proteine) and FoxO3 nuclear expression, and reduced beta galactosidase (zeige GLB1 Proteine) and survivin (zeige BIRC5 Proteine) expression.
geminin (zeige GMNN Proteine) selectively couples the transcription factor forkhead box O3 (FoxO3) to HDAC3 (zeige HDAC3 Proteine), thereby specifically facilitating FoxO3 deacetylation.
Data suggest that forkhead box O3A protein (FoxO3a) might be a prognostic biomarker or a potential therapeutic target in glioblastoma.
MiR (zeige MLXIP Proteine)-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a.
Our results show for the first time that DC FOXO3 expression and function is altered in females. In vitro results indicate that these differences may be the result of exposure to estrogen. These differences may be critical considerations for the enhancement of immunotherapy for cancer.
Data, including data from studies using transgenic/knockout mice, suggest that FoxO3 activation via post-translational phosphorylation can both induce and maintain autophagic activities in renal tubule epithelium in response to injury from unilateral ureteral obstruction; under these conditions, nuclear expression of FoxO3 is up-regulated in hypoxic proximal tubules exhibiting high levels of autophagy.
The Foxo3-Eomes (zeige EOMES Proteine) pathway is central to achieve the complete specialized gene program required for pathogenic Th1 (zeige HAND1 Proteine) cell differentiation.
these results show that Cdk5 (zeige CDK5 Proteine)-mediated phospho-regulation of Foxo3 can activate several genes that promote neuronal death and aberrant Abeta (zeige APP Proteine) processing, thereby contributing to the progression of neurodegenerative pathologies.
the transcription factor Forkhead box O3 (FoxO3) was found to be an essential regulator of the maintenance of pluripotency in dormant embryonic stem cells.
Loss of Foxo3 function resulted in more severe arthritis in vivo (both clinically and histologically) and was associated with higher titers of anticollagen antibodies and interleukin-6 (zeige IL6 Proteine) in the blood.
results indicate that DNA damage accrued as a result of elevated ROS in Foxo3(-/-) mutant HSPC is at least partially reversible
Foxo1 (zeige FOXO1 Proteine), Foxo3a, and Foxo4 (zeige FOXO4 Proteine) in chondrocytes regulate endochondral bone formation.
Data show that resveratrol reduced mitochondrial reactive oxygen species (mROS) generation by promoting Sirt3 (zeige SIRT3 Proteine) enrichment within the mitochondria and subsequent upregulation of FoxO3a-mediated mitochondria gene expression of PGC-1alpha and SOD2 (zeige SOD2 Proteine).
These results indicate that myostatin (zeige MSTN Proteine) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor (zeige NR3C1 Proteine) binding to its promoter.
In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)
PTEN, FOXO3A and PKB (zeige AKT1 Proteine) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.
Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.
FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea
NO/protein kinase (zeige CDK7 Proteine) G (PKG (zeige PRKG1 Proteine))-dependent downregulation of PGC-1 alpha and the ROS (zeige ROS1 Proteine) detoxification system in endothelial cells are mediated by the PI3K/Akt (zeige AKT1 Proteine) signaling pathway and subsequent inactivation of transcription factor Foxo3a.
FOXO is a key regulator of ROS (zeige ROS1 Proteine)-induced apoptosis in mammalian cells.
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
forkhead box O3A
, forkhead box protein O3
, forkhead homolog (rhabdomyosarcoma) like 1
, forkhead in rhabdomyosarcoma-like 1
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
, forkhead box O3a
, forkhead protein FKHR2
, forkhead box O3A transcription factor
, forkhead box O3
, forkhead box O protein
, forkhead box protein O3-like