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FOXO3 Proteine (FOXO3)

Forkhead Box O3 Proteine (FOXO3)
Auf finden Sie aktuell 9 Forkhead Box O3 (FOXO3) Proteine von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen FOXO3 Antikörper (295) und FOXO3 Kits (38) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 354 FOXO3 Produkte verfügbar.
1110048B16Rik, 2010203A17Rik, AF6q21, C76856, Fkhr2, Fkhrl1, FKHRL1P2, foxO, FOXO-3, FOXO2, foxO3, FoxO3A, wu:fb50g02, wu:fi33f07, xfoxo3, zgc:92176
alle Proteine anzeigen Gen GeneID UniProt
FOXO3 2309 O43524
FOXO3 56484 Q9WVH4
Ratte FOXO3 FOXO3 294515  

Weitere Synonyme anzeigen

FOXO3 Proteine (FOXO3) nach Spezies

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Am meisten referenzierte FOXO3 Proteine

  1. Human FOXO3 Protein expressed in HEK-293 Cells - ABIN2712289 : Thompson, Larson, Vidrine, Barrios, Navarro, Meyers, Simms, Prajapati, Chitsike, Hellman, Baker, Watkins: FOXO3-NF-κB RelA Protein Complexes Reduce Proinflammatory Cell Signaling and Function. in Journal of immunology (Baltimore, Md. : 1950) 2015 (PubMed)

Weitere Proteine zu FOXO3 Interaktionspartnern

Zebrafish Forkhead Box O3 (FOXO3) Interaktionspartner

  1. by modulating hypoxia-inducible factor activity via up-regulation of VHL (zeige VHL Proteine), FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.

  2. This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.

Human Forkhead Box O3 (FOXO3) Interaktionspartner

  1. Shikonin induces apoptosis in some lung cancer cells via activation of FOXO3a/EGR1 (zeige EGR1 Proteine)/SIRT1 (zeige SIRT1 Proteine) signaling, and AKT (zeige AKT1 Proteine) and p300 (zeige EP300 Proteine) negatively regulate this process via Bim (zeige BCL2L11 Proteine) upregulation.

  2. the accumulation of reactive oxygen species (ROS (zeige ROS1 Proteine)) in cells expressing JAK2V617F compromises the NHE-1 (zeige SLC9A1 Proteine)/Bcl-xL (zeige BCL2L1 Proteine) deamidation pathway by repressing NHE-1 (zeige SLC9A1 Proteine) upregulation in response to DNA damage. hematopoietic stem cells (HSCs), FOXO3A is largely localized within the nuclei despite the presence of JAK2V617F mutation, suggesting that JAK2 (zeige JAK2 Proteine)-FOXO signaling has a different effect on progenitors compared with stem cells.

  3. PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine)/FoxO3a signaling pathway role in melanoma cells

  4. High FOXO3a and p38 expression could predict the response to cetuximab in patients with CRC harbouring WT KRAS.

  5. Kaplan-Meier survival analysis showed that pancreatic ductal adenocarcinoma patients with negative forkhead box P1 (zeige FOXP1 Proteine) and forkhead box O3a expression survived significantly shorter than patients with positive forkhead box P1 (zeige FOXP1 Proteine) and forkhead box O3a expression (p = 0.000).

  6. The aims of this study were to quantify the mortality risk for the longevity-associated genotype and to discover the particular cause(s) of death associated with FOXO3 G allele in older Americans of diverse ancestry.

  7. These data suggest that miR (zeige MLXIP Proteine)-592 may promote the progression and metastasis, in part, by targeting FoxO3A in colorectal cancer

  8. This study indicates that CKII (zeige CSNK2A1 Proteine) can modulate the intracellular reactive oxygen species level via FoxO3a.

  9. by modulating hypoxia-inducible factor activity via up-regulation of VHL (zeige VHL Proteine), FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.

  10. Glucocorticoids treatment was found to rescue FOXO3a expression both in SLE mice and in SLE patients.

Mouse (Murine) Forkhead Box O3 (FOXO3) Interaktionspartner

  1. results indicate that DNA damage accrued as a result of elevated ROS in Foxo3(-/-) mutant HSPC is at least partially reversible

  2. Foxo1 (zeige FOXO1 Proteine), Foxo3a, and Foxo4 (zeige FOXO4 Proteine) in chondrocytes regulate endochondral bone formation.

  3. Data show that resveratrol reduced mitochondrial reactive oxygen species (mROS) generation by promoting Sirt3 (zeige SIRT3 Proteine) enrichment within the mitochondria and subsequent upregulation of FoxO3a-mediated mitochondria gene expression of PGC-1alpha and SOD2 (zeige SOD2 Proteine).

  4. Regulatory loop between FOXO3 and lipid droplets is required for intestinal inflammation.

  5. Maternal diabetes induced caspase 3 (zeige CASP3 Proteine)-dependent apoptosis in Sca1 (zeige ATXN1 Proteine)(+) cardiac progenitor cells derived from embryonic day 17.5 (E17.5). Both maternal diabetes and high glucose in vitro activated the pro-apoptotic transcription factor, Forkhead O 3a (FoxO3a) via dephosphorylation at threonine 32 (Thr (zeige TRH Proteine)-32) residue.

  6. Mechanistically, exercise-induced nuclear transcription factor FOXO3 binds to the CHCHD4 (zeige CHCHD4 Proteine) promoter and represses its expression, preventing the translocation of p53 (zeige TP53 Proteine) to the mitochondria and thereby increasing p53 (zeige TP53 Proteine) nuclear localization.

  7. Kit inactivation within oocytes also led to premature ovarian failure, albeit via a contrasting phenotype. Despite normal initial complements of primordial follicles, oocytes remained dormant with arrested oocyte maturation. Foxo3 protein localization in the nucleus versus cytoplasm explained both mutant phenotypes.

  8. Glucocorticoids treatment was found to rescue FOXO3a expression both in SLE mice and in SLE patients.

  9. the activation of ERK5 (zeige MAPK7 Proteine)-AKT (zeige AKT1 Proteine)-FoxO3a signaling pathways by fluid shear stress resulted in a decreased expression of FasL (zeige FASL Proteine) and Bim (zeige BCL2L11 Proteine) and an inhibition of caspase-3 (zeige CASP3 Proteine) activation, which exerts a protective effect that prevents osteoblasts from apoptosis.

  10. Our results suggest that FoxO3a exerts a negative control over mTOR (zeige FRAP1 Proteine), and its loss could result in autophagic defects in LD associated with laforin (zeige EPM2A Proteine) deficiency.

Pig (Porcine) Forkhead Box O3 (FOXO3) Interaktionspartner

  1. These results indicate that myostatin (zeige MSTN Proteine) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor (zeige NR3C1 Proteine) binding to its promoter.

  2. In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)

  3. PTEN, FOXO3A and PKB (zeige AKT1 Proteine) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.

  4. Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.

  5. FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea

Cow (Bovine) Forkhead Box O3 (FOXO3) Interaktionspartner

  1. NO/protein kinase (zeige CDK7 Proteine) G (PKG (zeige PRKG1 Proteine))-dependent downregulation of PGC-1 alpha and the ROS (zeige ROS1 Proteine) detoxification system in endothelial cells are mediated by the PI3K/Akt (zeige AKT1 Proteine) signaling pathway and subsequent inactivation of transcription factor Foxo3a.

  2. FOXO is a key regulator of ROS (zeige ROS1 Proteine)-induced apoptosis in mammalian cells.

FOXO3 Protein Überblick

Protein Überblick

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.

Alternative names and synonyms associated with FOXO3

  • forkhead box O3 (FOXO3)
  • forkhead box O3A (foxo3a)
  • forkhead box O3 (foxo3)
  • forkhead box O3 (foxO3)
  • forkhead box O3 (Foxo3)
  • 1110048B16Rik Protein
  • 2010203A17Rik Protein
  • AF6q21 Protein
  • C76856 Protein
  • Fkhr2 Protein
  • Fkhrl1 Protein
  • FKHRL1P2 Protein
  • foxO Protein
  • FOXO-3 Protein
  • FOXO2 Protein
  • foxO3 Protein
  • FoxO3A Protein
  • wu:fb50g02 Protein
  • wu:fi33f07 Protein
  • xfoxo3 Protein
  • zgc:92176 Protein

Bezeichner auf Proteinebene für Forkhead Box O3 Proteine (FOXO3)

forkhead box O3 , forkhead box O3A , fb50g02 , fi33f07 , forkhead box O protein , forkhead box protein O3-like , forkhead box protein O3 , forkhead homolog (rhabdomyosarcoma) like 1 , forkhead in rhabdomyosarcoma-like 1 , forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1 , forkhead box O3a , forkhead protein FKHR2 , xFoxO3 , forkhead box O3A transcription factor

445015 Canis lupus familiaris
494532 Danio rerio
462921 Pan troglodytes
700731 Macaca mulatta
100066558 Equus caballus
100125025 Xenopus (Silurana) tropicalis
100303473 Saccoglossus kowalevskii
100406446 Callithrix jacchus
100451077 Pongo abelii
100600519 Nomascus leucogenys
2309 Homo sapiens
56484 Mus musculus
444992 Xenopus laevis
481954 Canis lupus familiaris
733621 Sus scrofa
294515 Rattus norvegicus
535530 Bos taurus
100713179 Cavia porcellus
421769 Gallus gallus
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