CDK6 Proteine (CDK6)

Bezeichnung:
Cyclin-Dependent Kinase 6 Proteine (CDK6)
Auf www.antikoerper-online.de finden Sie aktuell 13 Cyclin-Dependent Kinase 6 (CDK6) Proteine von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CDK6 Antikörper (256) und CDK6 Kits (13) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 297 CDK6 Produkte verfügbar.
Synonyme:
5830411I20, AI504062, CDK6, Crk2, PLSTIRE
alle Proteine anzeigen Gen GeneID UniProt
CDK6 1021 Q00534
CDK6 12571 Q64261
Ratte CDK6 CDK6 114483  

Weitere Synonyme anzeigen

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Weitere Proteine zu CDK6 Interaktionspartnern

Human Cyclin-Dependent Kinase 6 (CDK6) Interaktionspartner

  1. Describe a regulatory loop miR (zeige MLXIP Proteine)-218-CDK6/CyclinD1-E2F1 (zeige E2F1 Proteine) whose disruption may contribute to cell cycle progression in gastric cancer.

  2. Specific E2Fs also have prognostic value in breast cancer, independent of clinical parameters. We discuss here recent advances in understanding of the RB-E2F (zeige E2F1 Proteine) pathway in breast cancer. We also discuss the application of genome-wide genetic screening efforts to gain insight into synthetic lethal interactions of CDK4/6 (zeige CDK4 Proteine) inhibitors in breast cancer for the development of more effective combination therapies.

  3. The deletion of CBX3 (zeige CBX3 Proteine) directly enforces the expression of CDK6 and p21 (zeige CDKN1A Proteine).

  4. Amplification of the G1-S regulatory genes, CCNE1, CCND1 and CdK6, represent an early event, which precedes ERBB2, EGFR, or KRAS amplification in gastric adenocarcinoma.

  5. CDK6-mediated suppression of CD25 (zeige IL2RA Proteine) is required for initiation of T-ALL by activated Notch1 (zeige NOTCH1 Proteine)

  6. CDK6 overexpression is associated with cancer.

  7. High CDK6 expression is associated with Melanoma.

  8. Palbociclib can overcome mutations in cyclin dependent kinase 6 that break hydrogen bonds between the drug and the protein

  9. Our study proved that the CDK6 gene is a target of miR (zeige MLXIP Proteine)-637, and demonstrated the regulatory association between miR (zeige MLXIP Proteine)-637 and CDK6

  10. we verified that miR (zeige MLXIP Proteine)-892b regulates the p19ARF/cyclin D1 (zeige CCND1 Proteine)/CDK6 and Sp-1 (zeige PSG1 Proteine)/MMP-9 (zeige MMP9 Proteine) signaling networks in bladder cancer cells and may provide a treatment option for advanced-stage bladder cancers.

Mouse (Murine) Cyclin-Dependent Kinase 6 (CDK6) Interaktionspartner

  1. PD 0332991 (PD), an FDA-approved selective inhibitor of cyclin-dependent kinase 4/6 (CDK4/6 (zeige CDK4 Proteine)), prevents radiation-induced lethal intestinal injury in mice. Treating mice with PD or a structurally distinct CDK4/6 (zeige CDK4 Proteine) inhibitor prior to radiation blocked proliferation and crypt apoptosis and improved crypt regeneration.

  2. CDK6-mediated suppression of CD25 (zeige IL2RA Proteine) is required for initiation of T-ALL by activated Notch1 (zeige NOTCH1 Proteine). . Pharmacologic inhibition of CDK6 kinase induces CD25 (zeige IL2RA Proteine) and RUNX1 (zeige RUNX1 Proteine) expression, cell cycle arrest and apoptosis in mouse and human T-ALL.

  3. Fbxo7 (zeige FBXO7 Proteine)-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 (zeige CDKN1B Proteine) levels. These studies reveal differential cell cycle regulation by Fbxo7 (zeige FBXO7 Proteine) at different stages in T-cell development.

  4. Taken together, our results suggested that microRNA-33 enhanced the replicative senescence of MEFs potentially by suppressing CDK6 expression.

  5. Data show that E11/glycoprotein 38 (zeige PDPN Proteine)(GP38 (zeige PDPN Proteine)) was up-regulated upon SEMA3A (zeige SEMA3A Proteine) stimulation, and cyclin-dependent kinase 6 (CDK6) was down-regulated in a time-dependent manner.

  6. Notch3 (zeige NOTCH3 Proteine) transcription and growth of lymphoma cells was dependent on CDK6.

  7. CDK6 is an important regulator of stem cell activation and an essential component of a transcriptional complex that suppresses Egr1 (zeige EGR1 Proteine) in hematopoietic and leukemic stem cell activation

  8. Cdk4 (zeige CDK4 Proteine) and Cdk6 cooperate in hematopoietic tumor development and suggest a role for Cdk6 in sequestering INK4 proteins away from Cdk4 (zeige CDK4 Proteine).

  9. Cdk6/Ccnd1 (zeige CCND1 Proteine) overexpression inhibits chondrocyte maturation and enhances G1/S transition by phosphorylating pRb (zeige PGR Proteine); the chondrocytes then undergo p53 (zeige TP53 Proteine)-dependent apoptosis

  10. p107 (zeige RBL1 Proteine) retinoblastoma protein is regulated by Cdk6/Ccnd1 (zeige CCND1 Proteine) in growth plates.

Cow (Bovine) Cyclin-Dependent Kinase 6 (CDK6) Interaktionspartner

  1. the T-1075C SNP of bovine CDK6 is significantly associated with body length and heart girth

CDK6 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Alternative names and synonyms associated with CDK6

  • cyclin-dependent kinase 6 (CDK6)
  • cyclin-dependent kinase 6 (Cdk6)
  • 5830411I20 Protein
  • AI504062 Protein
  • CDK6 Protein
  • Crk2 Protein
  • PLSTIRE Protein

Bezeichner auf Proteinebene für CDK6

cyclin-dependent kinase 6 , cell division protein kinase 6-like , cell division protein kinase 6 , serine/threonine-protein kinase PLSTIRE , CR2 protein kinase

GENE ID SPEZIES
746968 Pan troglodytes
100454924 Pongo abelii
1021 Homo sapiens
12571 Mus musculus
114483 Rattus norvegicus
609920 Canis lupus familiaris
511754 Bos taurus
420558 Gallus gallus
100518921 Sus scrofa
100009040 Oryctolagus cuniculus
100061625 Equus caballus
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