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in ovarian cancer cells, DOT1L (zeige DOT1L Proteine) regulates the transcription of G1 phase genes CDK6 and CCND3 (zeige CCND3 Proteine) through H3K79 dimethylation
the MYU/hnRNP-K (zeige HNRNPK Proteine)/CDK6 pathway functions downstream of Wnt/c (zeige WNT7B Proteine)-Myc (zeige MYC Proteine) signaling and plays a critical role in the proliferation and tumorigenicity of colon cancer cells.
metabolic function of cyclin D3 (zeige CCND3 Proteine)-CDK6 kinase in cancer cell survival
Describe a regulatory loop miR (zeige MLXIP Proteine)-218-CDK6/CyclinD1-E2F1 (zeige E2F1 Proteine) whose disruption may contribute to cell cycle progression in gastric cancer.
Specific E2Fs also have prognostic value in breast cancer, independent of clinical parameters. We discuss here recent advances in understanding of the RB-E2F (zeige E2F1 Proteine) pathway in breast cancer. We also discuss the application of genome-wide genetic screening efforts to gain insight into synthetic lethal interactions of CDK4/6 (zeige CDK4 Proteine) inhibitors in breast cancer for the development of more effective combination therapies.
The deletion of CBX3 (zeige CBX3 Proteine) directly enforces the expression of CDK6 and p21 (zeige CDKN1A Proteine).
Amplification of the G1-S regulatory genes, CCNE1, CCND1 and CdK6, represent an early event, which precedes ERBB2, EGFR, or KRAS amplification in gastric adenocarcinoma.
CDK6-mediated suppression of CD25 (zeige IL2RA Proteine) is required for initiation of T-ALL by activated Notch1 (zeige NOTCH1 Proteine)
CDK6 overexpression is associated with cancer.
High CDK6 expression is associated with Melanoma.
PD 0332991 (PD), an FDA-approved selective inhibitor of cyclin-dependent kinase 4/6 (CDK4/6 (zeige CDK4 Proteine)), prevents radiation-induced lethal intestinal injury in mice. Treating mice with PD or a structurally distinct CDK4/6 (zeige CDK4 Proteine) inhibitor prior to radiation blocked proliferation and crypt apoptosis and improved crypt regeneration.
CDK6-mediated suppression of CD25 (zeige IL2RA Proteine) is required for initiation of T-ALL by activated Notch1 (zeige NOTCH1 Proteine). . Pharmacologic inhibition of CDK6 kinase induces CD25 (zeige IL2RA Proteine) and RUNX1 (zeige RUNX1 Proteine) expression, cell cycle arrest and apoptosis in mouse and human T-ALL.
Fbxo7 (zeige FBXO7 Proteine)-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 (zeige CDKN1B Proteine) levels. These studies reveal differential cell cycle regulation by Fbxo7 (zeige FBXO7 Proteine) at different stages in T-cell development.
Taken together, our results suggested that microRNA-33 enhanced the replicative senescence of MEFs potentially by suppressing CDK6 expression.
Data show that E11/glycoprotein 38 (zeige PDPN Proteine)(GP38 (zeige PDPN Proteine)) was up-regulated upon SEMA3A (zeige SEMA3A Proteine) stimulation, and cyclin-dependent kinase 6 (CDK6) was down-regulated in a time-dependent manner.
Notch3 (zeige NOTCH3 Proteine) transcription and growth of lymphoma cells was dependent on CDK6.
CDK6 is an important regulator of stem cell activation and an essential component of a transcriptional complex that suppresses Egr1 (zeige EGR1 Proteine) in hematopoietic and leukemic stem cell activation
Cdk4 (zeige CDK4 Proteine) and Cdk6 cooperate in hematopoietic tumor development and suggest a role for Cdk6 in sequestering INK4 proteins away from Cdk4 (zeige CDK4 Proteine).
Cdk6/Ccnd1 (zeige CCND1 Proteine) overexpression inhibits chondrocyte maturation and enhances G1/S transition by phosphorylating pRb (zeige PGR Proteine); the chondrocytes then undergo p53 (zeige TP53 Proteine)-dependent apoptosis
p107 (zeige RBL1 Proteine) retinoblastoma protein is regulated by Cdk6/Ccnd1 (zeige CCND1 Proteine) in growth plates.
the T-1075C SNP of bovine CDK6 is significantly associated with body length and heart girth
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.
cyclin-dependent kinase 6
, cell division protein kinase 6-like
, cell division protein kinase 6
, serine/threonine-protein kinase PLSTIRE
, CR2 protein kinase