CDK4 Proteine (CDK4)

Bezeichnung:
Cyclin-Dependent Kinase 4 Proteine (CDK4)
Auf www.antikoerper-online.de finden Sie aktuell 41 Cyclin-Dependent Kinase 4 (CDK4) Proteine von 15 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CDK4 Antikörper (320) und CDK4 Kits (35) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 409 CDK4 Produkte verfügbar.
Synonyme:
8-6, cdk, cdk4, cdk4/6, CG5072, CMM3, Crk3, dCdk4, DmCdk4, Dmel\\CG5072, l(2)05428, l(2)0671, l(2)k06503, l(2)s4639, l(2)sh0671, Pk53C, Pk?7, PSK-J3, xcdk4, zgc:153726
alle Proteine anzeigen Gen GeneID UniProt
CDK4 1019 P11802
CDK4 12567 P30285
CDK4 94201 P35426

Weitere Synonyme anzeigen

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Am meisten referenzierte CDK4 Proteine

  1. Human CDK4 Protein expressed in Escherichia coli (E. coli) - ABIN1098680 : Kato, Matsuoka, Strom, Sherr: Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase. in Molecular and cellular biology 1994 (PubMed)
    Zeige alle 2 Referenzen für 1098680

  2. Human CDK4 Protein expressed in Wheat germ - ABIN1348950 : Bockstaele, Kooken, Libert, Paternot, Dumont, de Launoit, Roger, Coulonval: Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". in Molecular and cellular biology 2006 (PubMed)

Weitere Proteine zu CDK4 Interaktionspartnern

Zebrafish Cyclin-Dependent Kinase 4 (CDK4) Interaktionspartner

  1. Expression of cells a mutant CDK4 (CDK4(R24C)) in beta-cells enhanced beta-cell replication. CDK4(R24C) also dampened compensatory beta-cell neogenesis in larvae and improved glucose tolerance in adult zebrafish.

Human Cyclin-Dependent Kinase 4 (CDK4) Interaktionspartner

  1. these findings support that PIKE (zeige AGAP2 Proteine) amplification or overexpression coordinately acts with CDK4 to drive glioblastoma tumorigenesis.

  2. Specific E2Fs also have prognostic value in breast cancer, independent of clinical parameters. We discuss here recent advances in understanding of the RB-E2F (zeige E2F1 Proteine) pathway in breast cancer. We also discuss the application of genome-wide genetic screening efforts to gain insight into synthetic lethal interactions of CDK4/6 inhibitors in breast cancer for the development of more effective combination therapies.

  3. p16 in combination with MDM2 (zeige MDM2 Proteine) and CDK4 immunohistochemistry may help in the differential diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma.

  4. conclude that p16 is highly sensitive for retroperitoneal DDL. However, the lack of specificity limits the diagnostic utility compared with the more established markers MDM2 (zeige MDM2 Proteine) and CDK4

  5. CDK4 overexpression is associated with cancer.

  6. High CDK4 expression is associated with Melanoma.

  7. Staining for MDM2 (zeige MDM2 Proteine) and CDK4 was noted in 25/56 and 23/56 atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL), respectively, giving a sensitivity of 45% and 41% and a specificity of 98% and 92%. Staining was noted exclusively in the nuclei of atypical cells and not in the nuclei of adipocytes. Staining for MDM2 (zeige MDM2 Proteine) and CDK4 occurred in 2/125 and 10/117 benign lipomatous lesions, respectively.

  8. Data suggest that CDK4 (cyclin-dependent kinase 4) is degraded by anaphase-promoting complex/cyclosome (APC (zeige APC Proteine)/C) during metaphase-anaphase transition while its main regulator, cyclin D1 (zeige CCND1 Proteine), remains intact but is sequestered in cytoplasm; CDK4 protein reaccumulates in the following G1 phase and shuttles between nucleus and cytoplasm to facilitate nuclear import of cyclin D1 (zeige CCND1 Proteine); without CDK4, cyclin D1 (zeige CCND1 Proteine) cannot enter nucleus.

  9. Cdk4 inhibition leads to directing human mesenchymal stem cells to a multipotent neurogenic fate by inactivating Smads-STAT3 (zeige STAT3 Proteine) signaling.

  10. Reduced SIRT2 (zeige SIRT2 Proteine) expression during tumorigenesis failed to repress cyclindependent kinase 4 expression, which eventually led to accelerated cell proliferation.

Pig (Porcine) Cyclin-Dependent Kinase 4 (CDK4) Interaktionspartner

  1. The in vitro cultivation of cumulus cells was associated with cell proliferation and that Cx43 (zeige GJA1 Proteine) and Cdk4 gene expression was upregulated after in vitro cultivation, resulting in significantly higher protein levels.

Mouse (Murine) Cyclin-Dependent Kinase 4 (CDK4) Interaktionspartner

  1. PD 0332991 (PD), an FDA-approved selective inhibitor of cyclin-dependent kinase 4/6 (CDK4/6), prevents radiation-induced lethal intestinal injury in mice. Treating mice with PD or a structurally distinct CDK4/6 inhibitor prior to radiation blocked proliferation and crypt apoptosis and improved crypt regeneration.

  2. Cdk4 protein

  3. The results demonstrate a unique CDK4-mediated mitochondrial communication that allows cells to sense environmental genotoxic stress and boost mitochondrial homeostasis by enhancing phosphorylation and activation of MnSOD (zeige SOD2 Proteine).

  4. a crucial role of RXRa in suppression of UVB-induced melanomas in the context of driver mutations such as activated CDK4(R24C/R24C) or oncogenic NRAS(Q61K) and altered expression of p53 and PTEN

  5. Our data indicate that Cdk2 (zeige CDK2 Proteine) and Cdk4 play important overlapping roles in homeostatic and stress hematopoiesis, which need to be considered when using broad-spectrum cyclin-dependent kinase (zeige CDK1 Proteine) inhibitors for cancer therapy.

  6. CDK4 is a critical downstream target of MEN1 (zeige MEN1 Proteine)-dependent tumor suppression and is required for tumorigenic proliferation in the pituitary and pancreatic islet, whereas CDK2 (zeige CDK2 Proteine) is dispensable for tumorigenesis in these neuroendocrine cell types.

  7. Cdk4 and Cdk6 (zeige CDK6 Proteine) cooperate in hematopoietic tumor development and suggest a role for Cdk6 (zeige CDK6 Proteine) in sequestering INK4 proteins away from Cdk4.

  8. CDK4 seems to be expressed as multiple proteins that respond differently to different shRNAs, and have previously unrecognized functions at the S-G 2/M phases of the cell cycle via mechanisms independent of binding to CCND and RB.

  9. insulin (zeige INS Proteine) activates cyclin D1 (zeige CCND1 Proteine)-cyclin-dependent kinase 4 (Cdk4), which, in turn, increases GCN5 (zeige KAT2A Proteine) acetyltransferase activity and suppresses hepatic glucose production independently of cell cycle progression

  10. CDK4 deficiency markedly accelerated lymphoma development in the Emu-Myc (zeige MYC Proteine) transgenic model of B lymphoma

Fruit Fly (Drosophila melanogaster) Cyclin-Dependent Kinase 4 (CDK4) Interaktionspartner

  1. The results indicate that the precise regulation of neuronal Cdk4 activity is important to limit mitochondrial reactive oxygen species production and prevent neurodegeneration.

  2. CDK4 activity regulates mitobiogenesis by the activation of NRF-1 (zeige NRF1 Proteine) and consequent induction of Tfam (zeige TFAM Proteine) and mitochondrial ribossomal transcription.

  3. Delg and cyclin D/Cdk4 have roles in nutritional control of mitochondrial biogenesis in the Drosophila adipose tissue

  4. Cyclin D-cdk4 is not a master regulator of cell multiplication in Drosophila embryos

  5. mRpL12 (zeige MRPL12 Proteine) is required for CycD/Cdk4-induced cell growth

  6. Our data suggest that the growth-specific function of CycD/Cdk4 is conserved from arthropods to mammals.

CDK4 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

Alternative names and synonyms associated with CDK4

  • cyclin-dependent kinase 4 (cdk4)
  • cyclin-dependent kinase 4 (CDK4)
  • cyclin-dependent kinase 4 (Cdk4)
  • Cyclin-dependent kinase 4 (Cdk4)
  • 8-6 Protein
  • cdk Protein
  • cdk4 Protein
  • cdk4/6 Protein
  • CG5072 Protein
  • CMM3 Protein
  • Crk3 Protein
  • dCdk4 Protein
  • DmCdk4 Protein
  • Dmel\\CG5072 Protein
  • l(2)05428 Protein
  • l(2)0671 Protein
  • l(2)k06503 Protein
  • l(2)s4639 Protein
  • l(2)sh0671 Protein
  • Pk53C Protein
  • Pk?7 Protein
  • PSK-J3 Protein
  • xcdk4 Protein
  • zgc:153726 Protein

Bezeichner auf Proteinebene für CDK4

cell division protein kinase 4 , PSK-J3 , cyclin dependent kinase 4 , p34/cdk4 , serine/threonine kinase , Cell division protein kinase 4 , CG5072-PA , CG5072-PB , CG5072-PC , Cdk4-PA , Cdk4-PB , Cdk4-PC , Cyclin-dependent kinase 4/6 , cyclin-dependent kinase 4 , protein kinase-like 53C

GENE ID SPEZIES
777730 Danio rerio
1019 Homo sapiens
100144492 Sus scrofa
12567 Mus musculus
94201 Rattus norvegicus
481131 Canis lupus familiaris
510618 Bos taurus
100009039 Oryctolagus cuniculus
100717960 Cavia porcellus
100144756 Ovis aries
36854 Drosophila melanogaster
379406 Xenopus laevis
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