CDK1 Proteine (CDK1)

Bezeichnung:
Cyclin-Dependent Kinase 1 Proteine (CDK1)
Auf www.antikoerper-online.de finden Sie aktuell 29 Cyclin-Dependent Kinase 1 (CDK1) Proteine von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CDK1 Antikörper (760) und CDK1 Kits (43) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 881 CDK1 Produkte verfügbar.
Synonyme:
5363, cdc, cdc-2, cdc2, cdc2-a, CDC2A, CDC2AAT, cdc2Dm, cdc2x1.1, cdc28a, CDCDm, Cdk-1, cdk1, CDK1/CDC2, CDK2, CDKA1, CDKA;1, cell division control 2, CG5363, CYCLIN-DEPENDENT KINASE A;1, Dcdc2, dCdk1, Dm cdc2, Dmcdc2, DmCdk1, Dmel\\CG5363, group 4, l(2)31Eh, p34, p34cdc2, POL3, pold, PSTAIR, wu:fc30e01, xcdc2, zgc:92032
alle Proteine anzeigen Gen GeneID UniProt
CDK1 983 P06493
CDK1 12534 P11440
CDK1 54237 P39951

Weitere Synonyme anzeigen

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Am meisten referenzierte CDK1 Proteine

  1. Human CDK1 Protein expressed in Baculovirus infected Insect Cells - ABIN2003332 : Ubersax, Woodbury, Quang, Paraz, Blethrow, Shah, Shokat, Morgan: Targets of the cyclin-dependent kinase Cdk1. in Nature 2003 (PubMed)
    Zeige alle 2 Referenzen für 2003332

  2. Human CDK1 Protein expressed in Wheat germ - ABIN1348775 : Ovejero-Benito, Frade: Brain-derived neurotrophic factor-dependent cdk1 inhibition prevents G2/M progression in differentiating tetraploid neurons. in PLoS ONE 2013 (PubMed)

Weitere Proteine zu CDK1 Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Cyclin-Dependent Kinase 1 (CDK1) Interaktionspartner

  1. Cdk1 waves are not controlled by the mitotic switch but by a double-negative feedback between Cdk1 and Chk1 (zeige CHEK1 Proteine). In Drosophila embryos, Cdk1 positive feedback serves primarily to ensure the rapid onset of mitosis, while wave propagation is regulated by S phase events.

  2. Cdk1 phosphorylates the conserved centriole protein Sas-4 during mitosis. This creates a Polo-docking site that helps recruit Polo to daughter centrioles.

  3. Our results indicate that the cyclic changes in Gwl (zeige MASTL Proteine) localization at mitotic entry and exit are directly regulated by the antagonistic cyclin B-Cdk1 and PP2A (zeige PPP2R2B Proteine)-Tws enzymes

  4. Cdk1 mediates the role of TARA and CycA (zeige CCNA2 Proteine) in sleep regulation.

  5. Y15 phosphorylation can both inhibit Cdk1 catalytic activity and de-stabilize Cdk1/Cyclin (zeige PCNA Proteine) complexes, whereas T161 phosphorylation facilitates stable interactions between cyclin B and Cdk1.

  6. Phosphorylation of Cdk1 on Y15 appeared to be crucial for developmental and DNA damage-induced G2-phase checkpoint arrest, consistent with other evidence that Myt1 (zeige MYT1 Proteine) is the major Y15-directed Cdk1 inhibitory kinase at this stage of development.

  7. nonmuscle myosin II regulation by Cdc2 activity

  8. CDK1 activation may be the cell cycle regulated event that determines the timing of emi1 destruction.

  9. Data show that down-regulation of Cdc2 delayed pI mitosis and altered the polarity and the number of subsequent cell divisions.

  10. Data suggest that Cks30A interacts with Cdk1, and may regulate Cyclin A (zeige CCNA2 Proteine) levels through the activity of a female germline-specific anaphase-promoting complex, CDC20 (zeige CDC20 Proteine)-Cortex.

Human Cyclin-Dependent Kinase 1 (CDK1) Interaktionspartner

  1. Cdk-dependent phosphorylation of TRF1 on threonine 371 promotes TRF1 to interact with APBs in S and G2 phases independently of its binding to telomeric DNA. We have demonstrated that the interaction of (pT371)TRF1 with APBs is dependent upon ATM and homologous-recombination-promoting factors such as Mre11 and BRCA1.

  2. XIAP (zeige XIAP Proteine) is stable during mitotic arrest, but its function is controlled through phosphorylation by the mitotic kinase CDK1-cyclin-B1 (zeige CCNB1 Proteine) at S40.

  3. Results suggest that the cyclin-dependent kinase I (CDK1) phosphotyrosine (pTyr15) protein is a potential indicator of the progression of colorectal cancer.

  4. These results suggest that inhibition of CDK-1 in G2 causes unpredicted effects in mitosis, even after CDK-1 inhibition is relieved.

  5. Date show that when Wee1 (zeige WEE1 Proteine) alone is inhibited, Chk1 (zeige CHEK1 Proteine) suppresses CDC45 (zeige CDC45 Proteine) loading and thereby limits the extent of unscheduled replication initiation and subsequent S-phase DNA damage, despite very high CDK (zeige CDK4 Proteine)-activity.

  6. CDK1 is a positive regulator of the IFN signaling pathway. The overexpression of CDK1 might contribute to the abnormally amplified type I IFN signaling in systemic lupus erythematosus.

  7. the mechanism of Plk1 activation and the potential role of Bora phosphorylation by Cdk1, is reported.

  8. The data presented here suggest that the temporal separation of pro- and anti-apoptotic pathways by selective inhibition of CDK2 (zeige CDK2 Proteine) disrupts coherent signaling modules and may synergize with anti-proliferative drugs, averting toxic side effects from CDK1 inhibition.

  9. Study greatly increases the known substrate space of Cdk1 and adds to the understanding of how mitotic progression is regulated by Cdk1-dependent phosphorylation pathways.

  10. periodic phosphorylation of Ku70 (zeige XRCC6 Proteine) by cyclin-cyclin (zeige PCNA Proteine) dependent kinases prevents the interaction of Ku with replication origin after initiation events in S-phase.

Cow (Bovine) Cyclin-Dependent Kinase 1 (CDK1) Interaktionspartner

  1. Oligosaccharides of hyaluronan induce angiogenesis through distinct CD44 (zeige CD44 Proteine) and RHAMM (zeige HMMR Proteine)-mediated signalling pathways involving Cdc2 and gamma-adducin (zeige ADD3 Proteine).

Mouse (Murine) Cyclin-Dependent Kinase 1 (CDK1) Interaktionspartner

  1. loss of LAR (zeige PTPRF Proteine) activity resulted in reduced activity of CDK1.

  2. CDK1 is a positive regulator of the IFN signaling pathway. The overexpression of CDK1 might contribute to the abnormally amplified type I IFN signaling in systemic lupus erythematosus.

  3. Cdk1-induced desmin (zeige DES Proteine) phosphorylation is required for efficient separation of desmin (zeige DES Proteine)-IFs and generally detected in muscular mitotic cells in vivo.

  4. using in vitro dephosphorylation assays, we demonstrate that Mastl (zeige MASTL Proteine) promotes persistent MPS1 phosphorylation by inhibiting PP2A (zeige PPP2R2B Proteine)/B55 (zeige MINK1 Proteine)-mediated MPS1 dephosphorylation rather than affecting Cdk1 kinase activity. Our findings establish a key regulatory function of the Greatwall (zeige MASTL Proteine) kinase/Mastl (zeige MASTL Proteine) - PP2A (zeige PPP2R2B Proteine)/B55 (zeige MINK1 Proteine) pathway in preventing premature SAC (zeige ADCY10 Proteine) silencing

  5. oxidative stress-induced (zeige SQSTM1 Proteine) DNA damage of mouse zygotes triggers the cell cycle checkpoint, which results in G2/M cell cycle arrest, and that phospho-Cdc25B (zeige CDC25B Proteine) (Ser323), phospho-Cdc25C (zeige CDC25C Proteine) (Ser216), and phospho-Cdc2 (Tyr15) participate in activating the G2/M checkpoint.

  6. CDK1 is required upstream of a checkpoint-associated cell death as well as meiotic metaphase progression in mouse spermatocytes.

  7. CDK1 is a synthetic lethal target for KRAS mutant tumors.

  8. Our data demonstrate that ES cells are uniquely sensitive to CDK1 inhibition via a p53 (zeige TP53 Proteine)/NOXA (zeige PMAIP1 Proteine)/MCL1 (zeige MCL1 Proteine) pathway.

  9. Ubiquitin-dependent degradation of GATA 2 (zeige GATA2 Proteine) is promoted by Fbw7 (zeige FBXW7 Proteine), is cyclin B-CDK1-mediated Thr176 phosphorylation-dependent, and influences hematopoietic cell differentiation.

  10. HDAC3 (zeige HDAC3 Proteine) controls G2/M phase progression mainly through posttranslational stabilization of the G2/M cyclin-dependent kinase 1.

Zebrafish Cyclin-Dependent Kinase 1 (CDK1) Interaktionspartner

  1. intestinal clock controls the expression of key cell cycle regulators, such as cdc2, wee1 (zeige WEE1 Proteine), p21 (zeige CDKN1A Proteine), PCNA (zeige PCNA Proteine) and cdk2 (zeige CDK2 Proteine), but only weakly influences cyclin B1 (zeige CCNB1 Proteine), cyclin B2 (zeige CCNB2 Proteine) and cyclin E1 (zeige CCNE1 Proteine) expression.

Pig (Porcine) Cyclin-Dependent Kinase 1 (CDK1) Interaktionspartner

  1. CDK7 (zeige CDK7 Proteine) and CCNH (zeige CCNH Proteine) activate CDC2 by T161 phosphorylation and make up CDK-activating kinase (zeige CDK7 Proteine), which is required for normal meiotic progression during porcine oocyte maturation.

  2. Results describe the expression of maternal cyclin B1 (zeige CCNB1 Proteine) and Cdc2 during in vitro maturation of porcine oocytes.

  3. Data demonstrate the presence of a novel structure in the cortex of porcine oocytes that comprises ERES and transiently accumulates CDC2 prior to germinal vesicle breakdown.

  4. insufficient amount of Cdc2 and continuous activation of Wee1 B are the cause of meiotic failure of small oocytes in pigs

  5. These results suggest that the inhibitory phosphorylation of CDC2, which is catalyzed by pigWee1B (zeige WEE2 Proteine), but not pigMyt1, is involved in the meiotic arrest of porcine oocytes.

Xenopus laevis Cyclin-Dependent Kinase 1 (CDK1) Interaktionspartner

  1. the fine-tuning of Cdc6 (zeige CDC6 Proteine) accumulation is essential to ensure two meiotic waves of Cdk1 activation and to avoid unscheduled DNA replication during meiotic maturation.

  2. equilibrium between CDK1 and PP2A (zeige PPP2R2B Proteine) specifies the timing of M-phase entry and exit and regulates the dynamics of cyclin B degradation upon M-phase exit in Xenopus laevis first embryonic mitosis.

  3. CDK1 activation proceeds with concomitant inhibition by CDC6 (zeige CDC6 Proteine), which tunes the timing of the M-phase entry during the embryonic cell cycle

  4. Xenopus Cdk1-AS rescues HT2-19 cells from apoptosis.

  5. Ras suppresses cyclin-dependent kinase 1 in a complex manner: It induces continuous accumulation of cyclin B2 (zeige CCNB2 Proteine), but also causes persistent inhibitory phosphorylation of tyr (zeige TYR Proteine)-15-cyclin-dependent kinase 1.

  6. By promoting CtIP (zeige RBBP8 Proteine)-dependent resection of double-strand break (DSB) ends while preventing Rad51 chromatin assembly, Cdk1 inhibits both the nonhomologous and homologous modes of DSB repair during mitosis.

  7. Examination of H1 histones reveals isoform-specific regulation by Cdk1 and RanGTP; mitotic Cdk1 functions to enhance H1 binding in egg extracts and embryos

  8. Cdc2 displays cytoskeleton-dependent localization in blastomere cortex during Xenopus embryonic cell cycle.

  9. Results suggest that the specific synthesis of either B-type cyclins or c-Mos (zeige MOS Proteine), induced by progesterone, is required to induce meiotic maturation and Cdc2 activation.

  10. Cyclin B dissociation from CDK1 precedes cyclins B degradation upon CDK1 inactivation in mitotic embryo extracts and that proteasome proteolytic activity is dispensable for both activation and inactivation of CDK1 in such extracts.

Arabidopsis thaliana Cyclin-Dependent Kinase 1 (CDK1) Interaktionspartner

  1. CDKA;1 and CYCD3;2 are required for the terminal division in the stomatal lineage.

  2. Data indicate that the in vivo confirmation of substrates of CDKA;1 showing a direct link between cell proliferation and the control of the redox state.

  3. The crucial function of CDKA;1 is the control of the plant Retinoblastoma homolog RBR1 and codepletion of RBR1 and CDKA;1 rescued most defects of cdka;1 mutants.

  4. Expression of a dominant negative CDKA;1 allele under the control of the STM (zeige SHMT1 Proteine) promoter perturbs post-embryonic development. Inhibition of CDK (zeige CDK4 Proteine) activity at the shoot apex (zeige APEX1 Proteine) results in premature differentiation of shoot apical meristem cells.

  5. When a single cdka;1 sperm was delivered, either female gamete could be fertilized leading to similar proportions of seeds containing either a single endosperm or a single embryo.

  6. However, we show here that the DNA damage checkpoint in Arabidopsis can also operate independently of the phosphorylation of CDKA;1.

  7. CDC2A participates in the fertilization process of endosperm

  8. The balance between cell division and differentiation is regulated through the interaction between CDKA;1 and the antiphosphatase PAS2. [CDKA;1]

  9. The Arabidopsis thaliana Cdc2(+)/Cdc28 homolog CDKA;1 is also phosphorylated in the T-loop and that phosphorylation at the conserved Thr (zeige TRH Proteine)-161 residue is essential for its function.

  10. phosphorylation of T161 in Arabidopsis CDKA;1 is essential for cell division during male gametogenesis

Caenorhabditis elegans (C. elegans) Cyclin-Dependent Kinase 1 (CDK1) Interaktionspartner

  1. These results reveal a crucial and conserved role of phosphorylation of the N terminus of Bora for Plk1 activation and mitotic entry.

  2. CDK-1 regulates PLK-1 activity during mitosis in C. elegans embryos through multisite phosphorylation of the PLK-1 activator SPAT (zeige AGXT Proteine)-1

  3. Conversion of microtubule-organizing center state involves the conserved C. elegans centrosome protein SPD-2/CEP192 and cell-cycle-dependent kinase activity from the mitotic cell.

  4. Our results support a model in which CYB (zeige CSTB Proteine)-2.1/2/CDK-1 antagonize CUL-2 (zeige CUL2 Proteine) activity to promote stabilization of PAR-6 (zeige PARD6A Proteine) levels during polarization of the early C. elegans embryo.

  5. CDK-1 activates PLK-1 via SPAT (zeige AGXT Proteine)-1 phosphorylation to promote entry into mitosis.

  6. model in which Wnt signaling and CDK-1 modify WRM-1 in a temporal and spatial manner to unmask an intrinsic polarity cue required for proper orientation of the endomesoderm cell division axis

  7. results indicate that CDC-25.1 is required for maintaining proper rate of germline mitotic cell cycle; propose that CDC-25.1 regulates the rate of germline mitotic cell cycle by counteracting WEE (zeige WEE1 Proteine)-1.3 and by positively controlling CDK-1

  8. CDK-1 blocks rotation by inhibiting dynein association with microtubules.

  9. Use of loss- and gain-of-function genetic approaches demonstrates that CYY-1, a cyclin (zeige PCNA Proteine) box-containing protein, drives synapse removal in this process.

  10. NPP-16 and CDK-1 function to arrest prophase blastomeres in C. elegans embryos

CDK1 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with CDK1

  • cyclin-dependent kinase 1 (PtrCDKA-1)
  • cell division control protein2 homolog (cdc2)
  • CG5363 gene product from transcript CG5363-RA (cdc2)
  • cyclin-dependent kinase 1 (CDK1)
  • cyclin-dependent kinase 1 (Cdk1)
  • cyclin-dependent kinase 1 (cdk1)
  • cyclin-dependent kinase 1 (cdk1-a)
  • cyclin-dependent kinase A-1 (CDC2)
  • cyclin-dependent kinase-like 1 (LOC100346649)
  • polymerase (DNA directed), delta 1, catalytic subunit (pold1)
  • Protein CDK-1 (cdk-1)
  • 5363 Protein
  • cdc Protein
  • cdc-2 Protein
  • cdc2 Protein
  • cdc2-a Protein
  • CDC2A Protein
  • CDC2AAT Protein
  • cdc2Dm Protein
  • cdc2x1.1 Protein
  • cdc28a Protein
  • CDCDm Protein
  • Cdk-1 Protein
  • cdk1 Protein
  • CDK1/CDC2 Protein
  • CDK2 Protein
  • CDKA1 Protein
  • CDKA;1 Protein
  • cell division control 2 Protein
  • CG5363 Protein
  • CYCLIN-DEPENDENT KINASE A;1 Protein
  • Dcdc2 Protein
  • dCdk1 Protein
  • Dm cdc2 Protein
  • Dmcdc2 Protein
  • DmCdk1 Protein
  • Dmel\\CG5363 Protein
  • group 4 Protein
  • l(2)31Eh Protein
  • p34 Protein
  • p34cdc2 Protein
  • POL3 Protein
  • pold Protein
  • PSTAIR Protein
  • wu:fc30e01 Protein
  • xcdc2 Protein
  • zgc:92032 Protein

Bezeichner auf Proteinebene für CDK1

cyclin-dependent kinase 1 , PCO133105 , PCO133105_ov , cell division control protein 2 homolog , p34cdc2 , protein cdc2 kinase , putative cyclin-dependent kinase A family protein , CG5363-PA , cdc2 kinase , cdc2-PA , cyclin dependent kinase , cyclin-dependent kinase , cell cycle controller CDC2 , cell division cycle 2, G1 to S and G2 to M , cell division protein kinase 1 , p34 protein kinase , cell cycle p34 CDC2 kinase protein , cell division cycle 2 homolog A , cell division cycle control protein 2a , Cell division cycle control protein 2 , cell division cycle 2 , cell division cycle 2 protein , Cell division control protein 2 homolog 1 , cell division control protein 2-A , cell division cycle 2 like , cell division protein kinase 1-A , cyclin-dependent kinase 1-A , p34 protein kinase 1 , DNA polymerase delta , DNA-directed DNA polymerase delta 1 , polymerase (DNA directed), delta 1, catalytic subunit 125kDa

GENE ID SPEZIES
7472581 Populus trichocarpa
542270 Zea mays
34411 Drosophila melanogaster
983 Homo sapiens
281061 Bos taurus
12534 Mus musculus
54237 Rattus norvegicus
396252 Gallus gallus
80973 Danio rerio
488997 Canis lupus familiaris
100155762 Sus scrofa
100735946 Cavia porcellus
100861361 Capra hircus
100216432 Ovis aries
380246 Xenopus laevis
824036 Arabidopsis thaliana
100346649 Oryctolagus cuniculus
447518 Xenopus laevis
176374 Caenorhabditis elegans
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