CDC25A Proteine (CDC25A)

Cell Division Cycle 25 Homolog A (S. Pombe) Proteine (CDC25A)
Auf finden Sie aktuell 12 Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A) Proteine von 7 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CDC25A Antikörper (472) und CDC25A Kits (10) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 540 CDC25A Produkte verfügbar.
cdc25A, CDC25A2, D9Ertd393e, sb:cb317
alle Proteine anzeigen Gen GeneID UniProt
CDC25A 993 P30304
CDC25A 171102 P48965
CDC25A 12530  

Weitere Synonyme anzeigen

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Am meisten referenzierte CDC25A Proteine

  1. Human CDC25A Protein expressed in Escherichia coli (E. coli) - ABIN667374 : Sørensen, Syljuåsen, Falck, Schroeder, Rönnstrand, Khanna, Zhou, Bartek, Lukas: Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. in Cancer cell 2003 (PubMed)
    Zeige alle 2 Referenzen für 667374

Weitere Proteine zu CDC25A Interaktionspartnern

Zebrafish Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A) Interaktionspartner

  1. Stat3 (zeige STAT3 Proteine) regulates cell proliferation and axis extension in part via upregulation of Cdc25a expression during oogenesis. Accordingly, restoring Cdc25a expression in stat3 (zeige STAT3 Proteine) mutants partially suppressed cell proliferation and gastrulation defects.

Human Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A) Interaktionspartner

  1. These results identify a new positive regulatory loop between Cdc25A and its CDK-cyclin substrates which contributes to accelerate entry into mitosis through the regulation of Cdc25A activity in G2.

  2. The expression level of Cdc25A was significantly increased (<0.05) after treatment with miR (zeige MLXIP Proteine)-675 mimics.

  3. miR-497 modulates the growth of chondrosarcoma cells by targeting Cdc25A.

  4. This study demonstrated that the cell cycle pathway and the cdc25a gene may be crucial in the pathogenesis and progression of hepatocellular carcinoma.

  5. Increased CDC25A is associated with invasiveness in Non-small Cell Lung Cancer.

  6. Data indicate that nine compounds were identified with Ki values for CDC25A, -B and -C ranging from 0.01 to 4.4 muM.

  7. Identify CDC25A as an early cell cycle transducer of FLT3 (zeige FLT3 Proteine)-ITD oncogenic signaling, and as a promising target to inhibit proliferation and re-induce differentiation of FLT3 (zeige FLT3 Proteine)-ITD acute myeloid leukemia (zeige BCL11A Proteine) cells.

  8. STK38-mediated phosphorylation of CDC25A at Ser-76 and the subsequent degradation of CDC25A are required to promote DNA damage-induced G2/M checkpoint activation.

  9. let-7c suppresses HCC (zeige FAM126A Proteine) progression, possibly by directly targeting the cell cycle regulator CDC25A and indirectly affecting its downstream target molecules. Let-7c may therefore be an effective therapeutic target for HCC (zeige FAM126A Proteine).

  10. Results suggest that miR-449a may act as a tumor suppressor by targeting CDC25A in endometrial cancer.

Mouse (Murine) Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A) Interaktionspartner

  1. Our results identify Cdc25A as a potential target for neuroprotectant strategy for the treatment of delayed ischemic neuronal death.

  2. CDC25A-deficient embryonic stem cells resist high doses of ATR inhibitors, which we show is due to their failure to prematurely enter mitosis in response to the drugs.

  3. These results showed that IGF1 regulated the expression of BOULE and CDC25A mRNAs via ERK1/2 signaling and in T-independent pathway during spermatogenesis in the adult mouse testes.

  4. accelerated cholangiocyte cystogenesis is likely due to overexpression of Cdc25A

  5. Cdc25A activity is required for the metaphase II arrest in mouse oocytes.

  6. deletion of Cdc25a increased apoptosis and accelerated the elimination of DNA damage following UV

  7. In the DNA damage response, instead of inhibiting cyclin B-CDK1 (zeige CDK1 Proteine) through destruction of Cdc25A phosphatase, oocytes utilize an inhibitory phosphorylation of Cdc25B (zeige CDC25B Proteine).

  8. Cdc25A inhibitors block cell-cycle progression and proliferation, reduce liver and kidney weights and cyst growth in animal models of polycystic kidney/liver disease.

  9. CDC25A and CDC25B (zeige CDC25B Proteine) but not CDC25C (zeige CDC25C Proteine) compensate for each other to maintain the proliferative capacity of intestinal epithelial stem and progenitor cells

  10. IL-7 (zeige IL7 Proteine) drives Cdc25A-mediated T-cell proliferation, which prevents the nuclear translocation of Foxo1 (zeige FOXO1 Proteine), leading to reduced expression of CD62L (zeige SELL Proteine) and the migration of T cells into circulation.

Xenopus laevis Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A) Interaktionspartner

  1. Cdc25A is a key player in the developmentally regulated program of apoptosis in X. laevis embryos

  2. Strong ERK (zeige MAPK1 Proteine) activation can target Cdc25A for degradation in a manner similar to, but independent of, Chk1 (zeige CHEK1 Proteine) for cell cycle arrest.

CDC25A Protein Überblick

Protein Überblick

CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with CDC25A

  • cell division cycle 25 homolog A (S. pombe) (CDC25A)
  • cell division cycle 25A (cdc25a)
  • cell division cycle 25 homolog (cdc25)
  • cell division cycle 25A (CDC25A)
  • cell division cycle 25A (Cdc25a)
  • cdc25A Protein
  • CDC25A2 Protein
  • D9Ertd393e Protein
  • sb:cb317 Protein

Bezeichner auf Proteinebene für CDC25A

cell division cycle 25A , cell division cycle 25 homolog A , M-phase inducer phosphatase 1 , Dual specificity phosphatase Cdc25A , CDC25A2-CAG isoform , dual specificity phosphatase CDC25A , dual specificity phosphatase Cdc25A

460341 Pan troglodytes
733851 Xenopus (Silurana) tropicalis
57925 Danio rerio
420375 Gallus gallus
484780 Canis lupus familiaris
520188 Bos taurus
100064223 Equus caballus
993 Homo sapiens
171102 Rattus norvegicus
12530 Mus musculus
734734 Xenopus laevis
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