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anti-Aurora A (AURKA) Antikörper

Bezeichnung:
anti-Aurora Kinase A Antikörper (AURKA)
Auf www.antikoerper-online.de finden Sie aktuell 281 Aurora Kinase A (AURKA) Antikörper von 30 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Aurora A Proteine (26) und Aurora A Kits (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 330 Aurora A Produkte verfügbar.
Synonyme:
87A7-9/2, AIK, AIRK1, ARK-1, Ark1, AU019385, aur-a, AURA, aurka, aurka-a, Aurora-A, AURORA2, AW539821, Ayk1, BTAK, CG3068, ck10, ck[10], Dmel\\CG3068, Eg2, IAK, IAK1, l(3)87Ac, l(3)ck10, pEg2, PPP1R47, Stk6, STK7, STK15, wu:fb37c10, wu:fc02c02, zgc:100912
Alle Antikörper anzeigen Gen GeneID UniProt
AURKA 6790 O14965
AURKA 20878 P97477
AURKA 261730  

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Weitere Synonyme anzeigen

Meistgesuchte Reaktivitäten zu anti-Aurora A (AURKA) Antikörper

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anti-Human Aurora A Antikörper:

anti-Mouse (Murine) Aurora A Antikörper:

anti-Rat (Rattus) Aurora A Antikörper:

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Am meisten referenzierte anti-Aurora A Antikörper

  1. Human Monoclonal Aurora A Primary Antibody für IF, WB - ABIN393835 : Molli, Li, Bagheri-Yarmand, Pakala, Katayama, Sen, Iyer, Chernoff, Tsai, Nair, Kumar: Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. in The Journal of cell biology 2010 (PubMed)
    Zeige alle 5 Referenzen für ABIN393835

  2. Human Polyclonal Aurora A Primary Antibody für ICC, IF - ABIN151735 : Hontz, Li, Lingle, Negron, Bruzek, Salisbury, Li: Aurora a and B overexpression and centrosome amplification in early estrogen-induced tumor foci in the Syrian hamster kidney: implications for chromosomal instability, aneuploidy, and neoplasia. in Cancer research 2007 (PubMed)
    Zeige alle 5 Referenzen für ABIN151735

  3. Cow (Bovine) Monoclonal Aurora A Primary Antibody für ICC, IF - ABIN151177 : Cremet, Descamps, Vérite, Martin, Prigent: Preparation and characterization of a human aurora-A kinase monoclonal antibody. in Molecular and cellular biochemistry 2003 (PubMed)
    Zeige alle 2 Referenzen für ABIN151177

  4. Human Polyclonal Aurora A Primary Antibody für WB - ABIN374071 : Zhou, Kuang, Zhong, Kuo, Gray, Sahin, Brinkley, Sen: Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. in Nature genetics 1998 (PubMed)

  5. Human Polyclonal Aurora A Primary Antibody für EIA, IHC (p) - ABIN360272 : Kimura, Kotani, Hattori, Sumi, Yoshioka, Todokoro, Okano: Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1. in The Journal of biological chemistry 1997 (PubMed)

  6. Cow (Bovine) Polyclonal Aurora A Primary Antibody für IHC, WB - ABIN2777171 : Ye, Yang, Grossman, Dinney, Wu, Gu: Genetic variants in cell cycle control pathway confer susceptibility to bladder cancer. in Cancer 2008 (PubMed)

Weitere Antikörper gegen Aurora A Interaktionspartner

Fruit Fly (Drosophila melanogaster) Aurora Kinase A (AURKA) Interaktionspartner

  1. Disrupting the spindle assembly checkpoint in the aurA mutant does not prevent neuroblast amplification, tumor formation or chromosome segregation.

  2. Aurora A kinase activity contributes to phosphorylation of kinetochore substrates near poles and its inhibition results in chromosome misalignment and an increased incidence of erroneous kinetochore-MT attachments.

  3. AurA and aPKC exert the spatiotemporal control of Lgl distribution to achieve unique cell polarity roles in distinct cell types.

  4. Aurora A and B kinases directly phosphorylate Lgl to promote its mitotic relocalization.

  5. Drosophila melanogaster aurora A phosphorylates the dynactin (zeige DCTN1 Antikörper) subunit p150(glued (zeige DCTN1 Antikörper)) on sites required for its association with the mitotic spindle.

  6. One of the functions of Aurora A kinase is to direct centrosomal organization such that D-TACC complexed to the MSPS/XMAP215 (zeige CKAP5 Antikörper) microtubule-associated protein (zeige FAM82A2 Antikörper) may be recruited, and thus modulate the behavior of astral microtubules.

  7. Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis.

  8. Deletion mapping identifies a central domain of Aurora-A as essential for its centrosomal localization that is augmented by both the amino and the carboxyl terminal ends of the protein.

  9. Results suggest that Aurora-A regulates centrosome assembly by controlling centrosomin's (CNN) ability to target and/or anchor gamma-tubulin (zeige TUBG1 Antikörper) to the centrosome and to organize microtubule-nucleating sites via interaction with CNN.

  10. Aurora-A is essential for many crucial events during mitosis and phosphorylation of a series of substrates by Aurora-A at different stages of mitosis may promote diverse critical events in mitosis to maintain chromosome integrity in cells

Zebrafish Aurora Kinase A (AURKA) Interaktionspartner

  1. Zebrafish Aurora-A is critically required for embryonic proliferation during development.

Human Aurora Kinase A (AURKA) Interaktionspartner

  1. These findings reveal a novel regulation mechanism of SOX2 (zeige SOX2 Antikörper) phosphorylation mediated by AURKA in mitosis and its function in stem cell pluripotency maintenance in cancer cells.

  2. Results indicate that microRNA miR (zeige MLXIP Antikörper)-124 inhibited glioblastoma growth and potentiated chemosensitivity by targeting Aurora kinase A (AURKA), which may represent promising targets and rational therapeutic options for glioblastoma.

  3. MCRS1 (zeige MCRS1 Antikörper) is phosphorylated by the Aurora-A kinase in mitosis on Ser35/36.

  4. AURKA promotes cancer metastasis by regulating epithelial-mesenchymal transition and cancer stem cell properties in hepatocellular carcinoma.

  5. Our findings demonstrate that prolonged overexpression of Aurora-A can be a driver somatic genetic event in mammary adenocarcinomas associated with deregulated tumor-relevant pathways in the Aurora-A subset of human breast cancer

  6. Deregulated ERK1/2 (zeige MAPK1/3 Antikörper) MAP kinase (zeige MAPK1 Antikörper) signaling promotes aneuploidy by a Fbxw7beta-Aurora A pathway.

  7. activation of AurA kinase through FGF1 (zeige FGF1 Antikörper)/FGFR (zeige FGFR2 Antikörper) signaling axis sustains the stem cell characteristics of glioblastoma cells.

  8. This study found that miR (zeige MLXIP Antikörper)-137 reduced AURKA expression through interaction with its 3' untranslated region (3'UTR (zeige UTS2R Antikörper)) and that miR (zeige MLXIP Antikörper)-137 was negatively correlated with AURKA expression in melanoma specimens.

  9. Our study negatively correlates expression of PHLDA1 (zeige PHLDA1 Antikörper) and Aurora A in IMR-32 cells and sheds new light on functions of PHLDA1 (zeige PHLDA1 Antikörper) in the neuroblastoma (zeige ARHGEF16 Antikörper) tumor cells, suggesting its role as a pro-apoptotic protein

  10. Results confirmed that AURKA is highly expressed in lung adenocarcinoma tissues and human lung adenocarcinoma cell lines. Its knockdown in human lung adenocarcinoma could inhibit cell growth and proliferation in vitro providing evidence for its important roles in the proliferation of human lung adenocarcinoma cells.

Mouse (Murine) Aurora Kinase A (AURKA) Interaktionspartner

  1. Bcl2l10 (zeige BCL2L10 Antikörper), Tpx2 (zeige DAZL Antikörper), and Aurka co-localized on the meiotic spindles, and Bcl2l10 (zeige BCL2L10 Antikörper) was present in the same complex with Tpx2 (zeige DAZL Antikörper).

  2. Suppression of neuroendocrine and NEPC development by ICT was associated with dose-dependent inhibitory effects on abnormally elevated IL-6 (zeige IL6 Antikörper)/STAT3 (zeige STAT3 Antikörper) and Aurora kinase A in vitro and in vivo

  3. Our findings demonstrate that prolonged overexpression of Aurora-A can be a driver somatic genetic event in mammary adenocarcinomas associated with deregulated tumor-relevant pathways in the Aurora-A subset of human breast cancer

  4. Data show that aurora-A kinase (AURKA) supports effective spindle formation in zygote.

  5. observations revealed that the alteration of PKB-GSK-3beta axis, Plk-1, and Aurora kinase-A expressions in HSPC compartment due to DNA damage response was associated with the proliferative impairment and apoptosis during aplastic anemia.

  6. Augmented expression of Aurora kinase-A and Polo-like kinase-1 (zeige PLK1 Antikörper) at the lactogenic switch likely mediates the formation of binucleated cells.

  7. Aurora A inhibition causes delocalized clustering of Lck (zeige LCK Antikörper) at the immunological synapses and decreases its phosphorylation levels thus indicating Aurora A is required for maintaining Lck (zeige LCK Antikörper) active during T-cell activation.

  8. Ndel1 (zeige NDEL1 Antikörper) acts as a novel upstream regulator of the trichoplein-Aurora A pathway to inhibit primary cilia assembly.

  9. The Aurora kinase A and c-Myc (zeige MYC Antikörper) expression and histone H3 (zeige HIST3H3 Antikörper) phosphorylation level were comparatively higher in the cranial tumor than the caudal (zeige CAD Antikörper).

  10. aurora kinase A (AURKA) represents a new therapeutic target in primary myelofibrosis.

Cow (Bovine) Aurora Kinase A (AURKA) Interaktionspartner

  1. Aurora A was the most abundant form in oocytes, both at mRNA and protein levels, in bovine oocytes during meiotic maturation.

Pig (Porcine) Aurora Kinase A (AURKA) Interaktionspartner

  1. Aurora kinase A is unlikely to be involved in CPEB1 (zeige CPEB1 Antikörper) activating phosphorylation and cyclin B1 (zeige CCNB1 Antikörper) mRNA polyadenylation during meiotic maturation of porcine oocytes.

  2. Aurora-A may be a multifunctional kinase that plays pivotal regulatory roles in microtubule assembly during porcine oocyte meiotic maturation, fertilization and early embryonic mitosis

  3. Aurora A stimulates the protein synthesis and promotes the meiotic resumption.

Xenopus laevis Aurora Kinase A (AURKA) Interaktionspartner

  1. These results suggest a novel relationship between AurA and protein phosphatases during progression throughout the early embryonic cell cycle and shed new light on potential defects caused by AurA overexpression.

  2. MCAK (zeige KIF2C Antikörper) colocalized with NuMA (zeige NUMA1 Antikörper) and XMAP215 (zeige CKAP5 Antikörper) at the center of Ran asters where its activity is regulated by Aurora A-dependent phosphorylation of S196, which contributes to proper pole focusing

  3. Plx1 (zeige PLK1 Antikörper) promotes activation of Aurora A, most likely through TPX2.

  4. Aurora-A kinase is required for astral microtubule polymerization and spindle microtubule flux during chromosome segregation.

  5. Data show that Aurora A is a key regulator of microtubule assembly during M phase and therefore of bipolar spindle formation.

  6. binding and elution properties of both the phosphopeptides and unphosphorylated peptides of His6-Aurora A

  7. Results suggest that phosphorylation of maskin (zeige TACC3 Antikörper) by Aurora-A prevents meiosis II proteins from being produced during meiosis I.

  8. The N-terminal non-catalytic domain of Aurora-A can localize to the centrosome in Xenopus egg extracts, while GFP fusions of either the N-terminal or catalytic domains are targeted to the centrosome in Xenopus XL2 cells.

  9. Here we identify G205 in Xenopus Aurora A as a key determinant of both intrinsic activity and regulation by TPX2

  10. The catalytic domain alone of Aurora-A is sufficient to restore spindle bipolarity; additional N-terminal sequences function in mitotic timing.

Aurora A (AURKA) Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.

Alternative names and synonyms associated with Aurora A (AURKA)

  • aurora (aur) Antikörper
  • aurora kinase A (aurka) Antikörper
  • hypothetical protein (Aurora-A) Antikörper
  • aurora kinase A (AURKA) Antikörper
  • aurora kinase A (Aurka) Antikörper
  • 87A7-9/2 Antikörper
  • AIK Antikörper
  • AIRK1 Antikörper
  • ARK-1 Antikörper
  • Ark1 Antikörper
  • AU019385 Antikörper
  • aur-a Antikörper
  • AURA Antikörper
  • aurka Antikörper
  • aurka-a Antikörper
  • Aurora-A Antikörper
  • AURORA2 Antikörper
  • AW539821 Antikörper
  • Ayk1 Antikörper
  • BTAK Antikörper
  • CG3068 Antikörper
  • ck10 Antikörper
  • ck[10] Antikörper
  • Dmel\\CG3068 Antikörper
  • Eg2 Antikörper
  • IAK Antikörper
  • IAK1 Antikörper
  • l(3)87Ac Antikörper
  • l(3)ck10 Antikörper
  • pEg2 Antikörper
  • PPP1R47 Antikörper
  • Stk6 Antikörper
  • STK7 Antikörper
  • STK15 Antikörper
  • wu:fb37c10 Antikörper
  • wu:fc02c02 Antikörper
  • zgc:100912 Antikörper

Bezeichner auf Proteinebene für AURKA

A-type aurora kinase , AuroraA , CG3068-PA , aur-PA , aurora A , aurora A kinase , aurora kinase , aurora-A , early-A , fruhe2 , Aurora A , hypothetical protein , aurora kinase A , fb37c10 , fc02c02 , serine/threonine-protein kinase 6 , serine/threonine protein kinase 6 , aurora A kinase protein , serine/threonine-protein kinase 6-like , ARK-1 , Aurora-A kinase , IPL1-related kinase , aurora 2 , aurora-related kinase 1 , aurora/IPL1-like kinase , aurora/IPL1-related kinase 1 , breast tumor-amplified kinase , breast-tumor-amplified kinase , hARK1 , protein phosphatase 1, regulatory subunit 47 , serine/threonine kinase 6 , serine/threonine protein kinase 15 , serine/threonine-protein kinase 15 , serine/threonine-protein kinase aurora-A , aurora family kinase 1 , ipl1- and aurora-related kinase 1 , serine/threonine-protein kinase Ayk1 , ratAurA , Aurora-A , Serine/threonine-protein kinase 6 , aurora kinase A-A , p46Eg265 , pEg2 , serine/threonine-protein kinase 6-A , serine/threonine-protein kinase Eg2 , serine/threonine-protein kinase Eg2-A

GENE ID SPEZIES
41446 Drosophila melanogaster
549324 Xenopus (Silurana) tropicalis
7200473 Phaeodactylum tricornutum CCAP 1055/1
428167 Gallus gallus
445246 Danio rerio
469980 Pan troglodytes
698190 Macaca mulatta
100216431 Ovis aries
100303586 Saccoglossus kowalevskii
100398107 Callithrix jacchus
100459866 Pongo abelii
100469600 Ailuropoda melanoleuca
6790 Homo sapiens
20878 Mus musculus
261730 Rattus norvegicus
504437 Bos taurus
485940 Canis lupus familiaris
574063 Sus scrofa
397925 Xenopus laevis
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