anti-Aurora A (AURKA) Antikörper

Bezeichnung:
anti-Aurora Kinase A Antikörper (AURKA)
Auf www.antikoerper-online.de finden Sie aktuell 289 Aurora Kinase A (AURKA) Antikörper von 32 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Aurora A Proteine (30) und Aurora A Kits (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 342 Aurora A Produkte verfügbar.
Synonyme:
87A7-9/2, AIK, AIRK1, ARK-1, Ark1, AU019385, aur-a, AURA, aurka, aurka-a, Aurora-A, AURORA2, AW539821, Ayk1, BTAK, CG3068, ck10, ck[10], Dmel\\CG3068, Eg2, IAK, IAK1, l(3)87Ac, l(3)ck10, pEg2, PPP1R47, Stk6, STK7, STK15, wu:fb37c10, wu:fc02c02, zgc:100912
Alle Antikörper anzeigen Gen GeneID UniProt
AURKA 6790 O14965
AURKA 20878 P97477
AURKA 261730  

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Weitere Synonyme anzeigen

Meistgesuchte Reaktivitäten zu anti-Aurora A (AURKA) Antikörper

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anti-Human Aurora A Antikörper:

anti-Mouse (Murine) Aurora A Antikörper:

anti-Rat (Rattus) Aurora A Antikörper:

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Am meisten referenzierte anti-Aurora A Antikörper

  1. Human Polyclonal Aurora A Primary Antibody für ICC, IF - ABIN151735 : Hontz, Li, Lingle, Negron, Bruzek, Salisbury, Li: Aurora a and B overexpression and centrosome amplification in early estrogen-induced tumor foci in the Syrian hamster kidney: implications for chromosomal instability, aneuploidy, and neoplasia. in Cancer research 2007 (PubMed)
    Zeige alle 5 Referenzen für 151735

  2. Human Monoclonal Aurora A Primary Antibody für IF, WB - ABIN393835 : Molli, Li, Bagheri-Yarmand, Pakala, Katayama, Sen, Iyer, Chernoff, Tsai, Nair, Kumar: Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. in The Journal of cell biology 2010 (PubMed)
    Zeige alle 5 Referenzen für 393835

  3. Cow (Bovine) Monoclonal Aurora A Primary Antibody für ICC, IF - ABIN151177 : Cremet, Descamps, Vérite, Martin, Prigent: Preparation and characterization of a human aurora-A kinase monoclonal antibody. in Molecular and cellular biochemistry 2003 (PubMed)
    Zeige alle 2 Referenzen für 151177

  4. Human Polyclonal Aurora A Primary Antibody für IHC (p), WB - ABIN392389 : Kimura, Kotani, Hattori, Sumi, Yoshioka, Todokoro, Okano: Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1. in The Journal of biological chemistry 1997 (PubMed)

  5. Human Polyclonal Aurora A Primary Antibody für ELISA, WB - ABIN184572 : Zhou, Kuang, Zhong, Kuo, Gray, Sahin, Brinkley, Sen: Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. in Nature genetics 1998 (PubMed)

  6. Cow (Bovine) Polyclonal Aurora A Primary Antibody für IHC, WB - ABIN2777171 : Ye, Yang, Grossman, Dinney, Wu, Gu: Genetic variants in cell cycle control pathway confer susceptibility to bladder cancer. in Cancer 2008 (PubMed)

  7. Human Polyclonal Aurora A Primary Antibody für IF (p), IHC (p) - ABIN683398 : Ye, Li, Yang, Wang, Hao, Wang, Li, Du, Hao, Liu, Wang, Xia, Huang, Sun, Tian, Fan: Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation. in The Journal of experimental medicine 2014 (PubMed)

Weitere Antikörper gegen Aurora A Interaktionspartner

Fruit Fly (Drosophila melanogaster) Aurora Kinase A (AURKA) Interaktionspartner

  1. Disrupting the spindle assembly checkpoint in the aurA mutant does not prevent neuroblast amplification, tumor formation or chromosome segregation.

  2. Aurora A kinase activity contributes to phosphorylation of kinetochore substrates near poles and its inhibition results in chromosome misalignment and an increased incidence of erroneous kinetochore-MT attachments.

  3. AurA and aPKC exert the spatiotemporal control of Lgl distribution to achieve unique cell polarity roles in distinct cell types.

  4. Aurora A and B kinases directly phosphorylate Lgl to promote its mitotic relocalization.

  5. Drosophila melanogaster aurora A phosphorylates the dynactin (zeige DCTN1 Antikörper) subunit p150(glued (zeige DCTN1 Antikörper)) on sites required for its association with the mitotic spindle.

  6. One of the functions of Aurora A kinase is to direct centrosomal organization such that D-TACC complexed to the MSPS/XMAP215 (zeige CKAP5 Antikörper) microtubule-associated protein (zeige FAM82A2 Antikörper) may be recruited, and thus modulate the behavior of astral microtubules.

  7. Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis.

  8. Deletion mapping identifies a central domain of Aurora-A as essential for its centrosomal localization that is augmented by both the amino and the carboxyl terminal ends of the protein.

  9. Results suggest that Aurora-A regulates centrosome assembly by controlling centrosomin's (CNN) ability to target and/or anchor gamma-tubulin (zeige TUBG1 Antikörper) to the centrosome and to organize microtubule-nucleating sites via interaction with CNN.

  10. Aurora-A is essential for many crucial events during mitosis and phosphorylation of a series of substrates by Aurora-A at different stages of mitosis may promote diverse critical events in mitosis to maintain chromosome integrity in cells

Zebrafish Aurora Kinase A (AURKA) Interaktionspartner

  1. Zebrafish Aurora-A is critically required for embryonic proliferation during development.

Human Aurora Kinase A (AURKA) Interaktionspartner

  1. Results provide evidence that AURKA is a target for the VHL (zeige VHL Antikörper) E3 ligase ubiquitination.

  2. Results has uncovered a previous unknown positive feedback loop between AURKA and FOXM1 (zeige FOXM1 Antikörper) that promotes breast cancer stem cells (BCSCs) phenotypes and drug resistance. It showed that nuclear AURKA is recruited by FOXM1 (zeige FOXM1 Antikörper) to transactivate the expression of target genes, which also include FOXM1 (zeige FOXM1 Antikörper), whereas AURKA itself is also a downstream transcriptional target of FOXM1 (zeige FOXM1 Antikörper).

  3. AURKA protein over expression is associated with poor prognosis of malignant melanoma patients.

  4. AURKC (zeige AURKC Antikörper) rs758099 TT and (CC + CT) genotypes were positively associated with increased intestinal type gastric cancer (GC)risk, but not with an increased diffuse type GC risk. Based on these results, we can conclude that AURKA rs1047972 and AURKC (zeige AURKC Antikörper) rs758099 polymorphisms could affect the risk of GC development.

  5. We propose that the DDR (zeige DDR1 Antikörper) targets recruitment of Aurora A to the Plk1 (zeige PLK1 Antikörper)/Bora complex to prevent activation of Plk1 (zeige PLK1 Antikörper) during DNA damage in G2.

  6. C-A-T haplotypes combined with betel nut chewing lead to a high risk of oral squamous cell carcinoma

  7. TP53-mutated human H (zeige MYC Antikörper)CCs revealed inc (zeige TP53 Antikörper)reased AURKA expression and a positive correlation between AURKA and MYC expression.

  8. This is the first study that links Twist1 (zeige TWIST1 Antikörper) in a feedback loop with its activating kinase, which indicates that concurrent inhibition of AURKA and Twist1 (zeige TWIST1 Antikörper) will be synergistic in inhibiting pancreatic tumorigenesis and metastasis.

  9. Aurora A kinases and PP6 (zeige PPP6C Antikörper) phosphatases have an ancient function in modulating spindle positioning, thus contributing to faithful cell division.

  10. we report that Aurora A is essential for phosphorylation of the TRAF-interacting protein (zeige TANK Antikörper) TIFA (zeige IL22 Antikörper)

Mouse (Murine) Aurora Kinase A (AURKA) Interaktionspartner

  1. AURKA stabilizes MYC (zeige MYC Antikörper) to promote tp53 (zeige TP53 Antikörper)-altered liver tumor cell survival.

  2. Bcl2l10 (zeige BCL2L10 Antikörper), Tpx2 (zeige DAZL Antikörper), and Aurka co-localized on the meiotic spindles, and Bcl2l10 (zeige BCL2L10 Antikörper) was present in the same complex with Tpx2 (zeige DAZL Antikörper).

  3. Suppression of neuroendocrine and NEPC development by ICT was associated with dose-dependent inhibitory effects on abnormally elevated IL-6 (zeige IL6 Antikörper)/STAT3 (zeige STAT3 Antikörper) and Aurora kinase A in vitro and in vivo

  4. Our findings demonstrate that prolonged overexpression of Aurora-A can be a driver somatic genetic event in mammary adenocarcinomas associated with deregulated tumor-relevant pathways in the Aurora-A subset of human breast cancer

  5. Data show that aurora-A kinase (AURKA) supports effective spindle formation in zygote.

  6. observations revealed that the alteration of PKB-GSK-3beta axis, Plk-1, and Aurora kinase-A expressions in HSPC compartment due to DNA damage response was associated with the proliferative impairment and apoptosis during aplastic anemia.

  7. Augmented expression of Aurora kinase-A and Polo-like kinase-1 (zeige PLK1 Antikörper) at the lactogenic switch likely mediates the formation of binucleated cells.

  8. Aurora A inhibition causes delocalized clustering of Lck (zeige LCK Antikörper) at the immunological synapses and decreases its phosphorylation levels thus indicating Aurora A is required for maintaining Lck (zeige LCK Antikörper) active during T-cell activation.

  9. Ndel1 (zeige NDEL1 Antikörper) acts as a novel upstream regulator of the trichoplein-Aurora A pathway to inhibit primary cilia assembly.

  10. The Aurora kinase A and c-Myc (zeige MYC Antikörper) expression and histone H3 (zeige HIST3H3 Antikörper) phosphorylation level were comparatively higher in the cranial tumor than the caudal (zeige CAD Antikörper).

Cow (Bovine) Aurora Kinase A (AURKA) Interaktionspartner

  1. Aurora A was the most abundant form in oocytes, both at mRNA and protein levels, in bovine oocytes during meiotic maturation.

Pig (Porcine) Aurora Kinase A (AURKA) Interaktionspartner

  1. Aurora kinase A is unlikely to be involved in CPEB1 (zeige CPEB1 Antikörper) activating phosphorylation and cyclin B1 (zeige CCNB1 Antikörper) mRNA polyadenylation during meiotic maturation of porcine oocytes.

  2. Aurora-A may be a multifunctional kinase that plays pivotal regulatory roles in microtubule assembly during porcine oocyte meiotic maturation, fertilization and early embryonic mitosis

  3. Aurora A stimulates the protein synthesis and promotes the meiotic resumption.

Xenopus laevis Aurora Kinase A (AURKA) Interaktionspartner

  1. These results suggest a novel relationship between AurA and protein phosphatases during progression throughout the early embryonic cell cycle and shed new light on potential defects caused by AurA overexpression.

  2. MCAK (zeige KIF2C Antikörper) colocalized with NuMA (zeige NUMA1 Antikörper) and XMAP215 (zeige CKAP5 Antikörper) at the center of Ran asters where its activity is regulated by Aurora A-dependent phosphorylation of S196, which contributes to proper pole focusing

  3. Plx1 (zeige PLK1 Antikörper) promotes activation of Aurora A, most likely through TPX2.

  4. Aurora-A kinase is required for astral microtubule polymerization and spindle microtubule flux during chromosome segregation.

  5. Data show that Aurora A is a key regulator of microtubule assembly during M phase and therefore of bipolar spindle formation.

  6. binding and elution properties of both the phosphopeptides and unphosphorylated peptides of His6-Aurora A

  7. Results suggest that phosphorylation of maskin (zeige TACC3 Antikörper) by Aurora-A prevents meiosis II proteins from being produced during meiosis I.

  8. The N-terminal non-catalytic domain of Aurora-A can localize to the centrosome in Xenopus egg extracts, while GFP fusions of either the N-terminal or catalytic domains are targeted to the centrosome in Xenopus XL2 cells.

  9. Here we identify G205 in Xenopus Aurora A as a key determinant of both intrinsic activity and regulation by TPX2

  10. The catalytic domain alone of Aurora-A is sufficient to restore spindle bipolarity; additional N-terminal sequences function in mitotic timing.

Aurora A (AURKA) Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.

Alternative names and synonyms associated with Aurora A (AURKA)

  • aurora (aur) Antikörper
  • aurora kinase A (aurka) Antikörper
  • hypothetical protein (Aurora-A) Antikörper
  • aurora kinase A (AURKA) Antikörper
  • aurora kinase A (Aurka) Antikörper
  • 87A7-9/2 Antikörper
  • AIK Antikörper
  • AIRK1 Antikörper
  • ARK-1 Antikörper
  • Ark1 Antikörper
  • AU019385 Antikörper
  • aur-a Antikörper
  • AURA Antikörper
  • aurka Antikörper
  • aurka-a Antikörper
  • Aurora-A Antikörper
  • AURORA2 Antikörper
  • AW539821 Antikörper
  • Ayk1 Antikörper
  • BTAK Antikörper
  • CG3068 Antikörper
  • ck10 Antikörper
  • ck[10] Antikörper
  • Dmel\\CG3068 Antikörper
  • Eg2 Antikörper
  • IAK Antikörper
  • IAK1 Antikörper
  • l(3)87Ac Antikörper
  • l(3)ck10 Antikörper
  • pEg2 Antikörper
  • PPP1R47 Antikörper
  • Stk6 Antikörper
  • STK7 Antikörper
  • STK15 Antikörper
  • wu:fb37c10 Antikörper
  • wu:fc02c02 Antikörper
  • zgc:100912 Antikörper

Bezeichner auf Proteinebene für AURKA

A-type aurora kinase , AuroraA , CG3068-PA , aur-PA , aurora A , aurora A kinase , aurora kinase , aurora-A , early-A , fruhe2 , Aurora A , hypothetical protein , aurora kinase A , fb37c10 , fc02c02 , serine/threonine-protein kinase 6 , serine/threonine protein kinase 6 , aurora A kinase protein , serine/threonine-protein kinase 6-like , ARK-1 , Aurora-A kinase , IPL1-related kinase , aurora 2 , aurora-related kinase 1 , aurora/IPL1-like kinase , aurora/IPL1-related kinase 1 , breast tumor-amplified kinase , breast-tumor-amplified kinase , hARK1 , protein phosphatase 1, regulatory subunit 47 , serine/threonine kinase 6 , serine/threonine protein kinase 15 , serine/threonine-protein kinase 15 , serine/threonine-protein kinase aurora-A , aurora family kinase 1 , ipl1- and aurora-related kinase 1 , serine/threonine-protein kinase Ayk1 , ratAurA , Aurora-A , Serine/threonine-protein kinase 6 , aurora kinase A-A , p46Eg265 , pEg2 , serine/threonine-protein kinase 6-A , serine/threonine-protein kinase Eg2 , serine/threonine-protein kinase Eg2-A

GENE ID SPEZIES
41446 Drosophila melanogaster
549324 Xenopus (Silurana) tropicalis
7200473 Phaeodactylum tricornutum CCAP 1055/1
428167 Gallus gallus
445246 Danio rerio
469980 Pan troglodytes
698190 Macaca mulatta
100216431 Ovis aries
100303586 Saccoglossus kowalevskii
100398107 Callithrix jacchus
100459866 Pongo abelii
100469600 Ailuropoda melanoleuca
6790 Homo sapiens
20878 Mus musculus
261730 Rattus norvegicus
504437 Bos taurus
485940 Canis lupus familiaris
574063 Sus scrofa
397925 Xenopus laevis
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