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a primary functional variant of PRKCB (rs35015313) was identified by genotype imputation using a phased panel of 1,070 Japanese individuals from a prospective, general population cohort study and subsequent in vitro functional analyses. These results may lead to improved understanding of the disease pathways involved in primary biliary cholangitis.
our findings identify PRKCB gene as a novel candidate gene for familial Meniere's Disease (MD )and its expression gradient in supporting cells of the organ of Corti deserves attention, given the role of supporting cells in K(+ )recycling within the endolymph, and its apical turn location may explain the onset of hearing loss at low frequencies in MD
Activation of the Pro-Oxidant PKCbetaII-p66Shc (zeige SHC1 Proteine) Signaling Pathway Contributes to Pericyte Dysfunction in Skeletal Muscles of Patients With Diabetes With Critical Limb Ischemia
Taken together, these data argue for a complex mechanism of PKC-beta-dependent regulation of SH (zeige POLD3 Proteine)CA (p66) activation invol (zeige SIGLEC1 Proteine)ving Ser(139) and a motif surroun (zeige SIGLEC1 Proteine)ding Ser(213).
The study aimed to identify a small set of genetic signatures that may reliably predict the individuals with a high genetic propensity to heroin addiction. A set of 4 genes (JUN (zeige JUN Proteine), CEBPB (zeige CEBPB Proteine), PRKCB, ENO2 (zeige ENO2 Proteine), or CEBPG (zeige CEBPG Proteine)) could predict the diagnosis of heroin addiction with the accuracy rate around 85% in our dataset.
Our results provide compelling evidence that glucose-induced PKCalpha (zeige PKCa Proteine)/PKCbeta-mediated inhibition of Kv current in vascular smooth muscle causes an enhanced constrictor response. Inhibition of Kv current causes a significant depolarization of vascular myocytes leading to marked vasoconstriction
Data suggest that targeted manipulation of protein kinase C isoforms PKCalpha (zeige PKCa Proteine), PKCbeta, and PKCeta might be beneficial in certain proteinuric kidney diseases with altered transient receptor potential cation channel subfamily C member 6 (zeige TRPC6 Proteine) protein (TRPC6 (zeige TRPC6 Proteine)) functions.
Bone marrow stroma-induced resistance of chronic lymphocytic leukemia cells to arsenic trioxide involves Mcl-1 upregulation and is overcome by inhibiting the PI3Kdelta or PKCbeta signaling pathways.
PPAR-delta (zeige PPARD Proteine) and NKIRAS1 (zeige NKIRAS1 Proteine) are downstream mediators in the PRKCB pathway in human umbilical vein endothelial cells.
Lower hydrogen sulfide (zeige SQRDL Proteine) is associated with cardiovascular mortality, which involves PKCBII/Akt (zeige AKT1 Proteine) pathway in chronic hemodialysis patients.
propose that PKCbeta acts to suppress the degradation of FTO (zeige FTO Proteine) protein and reveals the associated role of PKCbeta and FTO (zeige FTO Proteine) in adipogenesis, suggesting a new pathway that affects the development of obesity and metabolic diseases
Cytosolic NELL2 specifically interacts with PKC beta isotypes and inhibits PKC beta1 through direct binding to the N-terminal pseudosubstrate domain of PKC beta1.
Taken together, these data argue for a complex mechanism of PKCbeta-dependent regulation of p66 (zeige POLD3 Proteine) activation involving Ser (zeige SIGLEC1 Proteine)(139) and a motif surrounding Ser (zeige SIGLEC1 Proteine)(213).
Translocation of PKC-betaII from the cytoplasm to membranes is required for phagocytosis of apoptotic cells and is inhibited by soluble beta-glucan
repressor of myogenesis; opposes calcineurin function
at the functionally mature calyx of Held synapse the Ca(2+)-dependent protein kinase C isoforms alpha and beta are necessary for post-tetanic potentiation, a form of plasticity thought to underlie short-term memory
a new mechanism by which PKC-beta activation promotes EC dysfunction caused by the de-regulation of the IL-18 (zeige IL18 Proteine)/IL-18BP (zeige IL18BP Proteine) pathway, leading to increased VCAM-1 (zeige VCAM1 Proteine) expression, monocyte/macrophage adhesion, and accelerated atherosclerotic plaque formation in diabetes
These results demonstrate the importance of PKCbetaII in chronic lymphocytic leukemia-like disease progression and suggest a role for PKCalpha (zeige PKCa Proteine) subversion in creating permissive conditions for leukemogenesis.
PKCbeta2 inhibition protects mice from gut (zeige GUSB Proteine) ischemia-reperfusion injury by suppressing the adaptor p66(Shc)-mediated oxidative stress and subsequent apoptosis.
PKC-alpha (zeige PKCa Proteine) and -betaIotaIota are the predominant isoforms in the developing optic pathway, whereas PKC-epsilon (zeige PRKCE Proteine) is the major form in the chiasmatic neurons.
The study identified the serine phosphorylation (p-Ser (zeige SIGLEC1 Proteine)) sites induced by PKC-Beta activation or AGT (zeige AGT Proteine), which inhibits insulin (zeige INS Proteine)-induced p-Tyr (zeige TYR Proteine) sites on IRS2 (zeige IRS2 Proteine) and its signals in endothelial cells.
ET-1 (zeige EDN1 Proteine)-mediated myocardial contractile dysfunction during cardioplegia involves activation of protein kinase C beta II.
The PKCalpha (zeige PKCa Proteine), PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.
Increases in epicardial perivascular adipose tissue leptin (zeige LEP Proteine) exacerbate coronary endothelial dysfunction in MetS via a PKC-beta-dependent pathway.
first study to show the expression and cellular localization of PKC beta I in the retina of pigs with development, and these results suggest that PKC beta I, in accordance with PKC alpha (zeige PKCa Proteine), plays important roles in signal transduction pathways in the pig retina with development
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
, protein kinase C beta type
, protein kinase C, beta 1 polypeptide
, protein kinase C beta-II
, protein kinase C, beta 1
, protein kinase C beta I
, protein kinase C beta II
, protein kinase C beta 1
, protein kinase C, beta
, protein kinase C beta 2