AXIN1 Proteine (AXIN1)

Bezeichnung:
Axin 1 Proteine (AXIN1)
Auf www.antikoerper-online.de finden Sie aktuell 8 Axin 1 (AXIN1) Proteine von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen AXIN1 Antikörper (144) und AXIN1 Kits (8) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 168 AXIN1 Produkte verfügbar.
Synonyme:
AI316800, Axin, AXIN1, AXIN1-RGS, Fu, fused, Kb, Ki, kinky, knobbly, LOC100226467, PPP1R49, wu:fi22e03, wu:fj14c08, wu:fk11b03, xAxin, zgc:109872
alle Proteine anzeigen Gen GeneID UniProt
AXIN1 8312 O15169
AXIN1 12005 O35625
AXIN1 79257 O70239

Weitere Synonyme anzeigen

AXIN1 Proteine (AXIN1) nach Spezies

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Am meisten referenzierte AXIN1 Proteine

  1. Human AXIN1 Protein expressed in HEK-293 Cells - ABIN2715088 : Cha, Cho, Lee, Lee, Jeong, Moon, Yun, Yang, Choi, Yoon, Kim, Kim, Kaduwal, Lee, Min, Kim, Han, Choi: Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation. in Nature chemical biology 2016 (PubMed)

Weitere Proteine zu AXIN1 Interaktionspartnern

Xenopus laevis Axin 1 (AXIN1) Interaktionspartner

  1. analysis of differential role of Axin RGS (zeige PITX2 Proteine) domain function in Wnt (zeige WNT2 Proteine) signaling during anteroposterior patterning and maternal axis formation

  2. APC (zeige APC Proteine) and Axin are involved in the Wnt (zeige WNT2 Proteine) pathway

  3. Axin binds directly to the export factor CRM1 (zeige XPO1 Proteine) in the presence of RanGTP

Human Axin 1 (AXIN1) Interaktionspartner

  1. role in the formation of degradasomes and degradation of beta-catenin (zeige CTNNB1 Proteine) induced by the TNKSi G007-LK in colorectal cancer cells

  2. VDR (zeige CYP27B1 Proteine) is important for the maintenance of physiological level of Axin1

  3. RUNX1 (zeige RUNX1 Proteine) and AXIN1 proteins are strongly correlated in ER(-) tumors as well.

  4. Mutagenesis and binding studies using the bivalent TNKS (zeige TNKS Proteine) binding domain of Axin1 demonstrate that only certain ankyrin repeat clusters combinations function together. SAXS analysis is consistent with a dynamic ensemble of TNKS (zeige TNKS Proteine) ankyrin repeat conformations modulated by Axin1 interaction.

  5. LGALS3 (zeige LGALS3 Proteine) and AXIN1 genes affect tumor sizes and the mucinous component via Wnt (zeige WNT2 Proteine)/ beta-catenin (zeige CTNNB1 Proteine) pathway in the pathogenesis of colorectal cancer

  6. The AXIN1 rs1805105 SNP was associated with small tumor size and early tumor stage in hepatocellular carcinoma.

  7. AXIN1 is expressed in meningioma along with APC (zeige APC Proteine) and E-cadherin (zeige CDH1 Proteine)

  8. Data show that poly(ADP-ribose) polymerase (PARP (zeige PARP1 Proteine)) enzyme Tankyrase (TNKS (zeige TNKS Proteine)) inhibition in colon cancer cells decreases beta-catenin (zeige CTNNB1 Proteine) signaling at the level of both Axin and APC2.

  9. Cancer point mutations in the scaffold protein (zeige HOMER1 Proteine) Axin derail Wnt (zeige WNT2 Proteine) signaling and promote tumor growth in vivo through a gain-of-function mechanism.

  10. The pool of ADP-ribosylated Axin, which is degraded under basal conditions, increases immediately following Wnt (zeige WNT2 Proteine) stimulation in both Drosophila and human cells.

Mouse (Murine) Axin 1 (AXIN1) Interaktionspartner

  1. Axin-1 is critical for spindle organization and cell cycle progression during meiotic maturation in mouse oocytes.

  2. VDR (zeige CYP27B1 Proteine) is important for the maintenance of physiological level of Axin1

  3. Axin1 promotes dendritic spine stabilization through Cdc42 (zeige CDC42 Proteine)-dependent cytoskeletal reorganization.

  4. Axin1 and Axin2 (zeige AXIN2 Proteine) do not have equivalent functions in satellite cells, but are both involved in repression of Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signalling to maintain proliferation and contribute to controlling timely myogenic differentiation.

  5. Study reports that NRF2 (zeige NFE2L2 Proteine) participates in the formation of a protein complex with Axin1/GSK-3/beta-TrCP (zeige BTRC Proteine) that is disrupted by WNT-3A (zeige WNT3A Proteine), a prototypic canonical WNT (zeige WNT2 Proteine) ligand, and leads to upregulation of the NRF2 (zeige NFE2L2 Proteine) transcriptional signature.

  6. Smurf1 (zeige SMURF1 Proteine)-mediated Lys29-linked nonproteolytic polyubiquitination of axin1 negatively regulates Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling.

  7. This study demonistrated that Axin directs the amplification and differentiation of intermediate progenitors in the developing cerebral cortex in mice.

  8. results suggestg HSV-1 replication enhancement might be mediated by the axin RGS (zeige PITX2 Proteine) domain.

  9. an asymmetrical distribution pattern for Axin1 transcripts in 2-cell embryos.

  10. Conditional disruption of Axin1 leads to development of liver tumors in mice.

Zebrafish Axin 1 (AXIN1) Interaktionspartner

  1. beta-catenin1 cannot revert the ich (zeige ACE Proteine) phenotype because it may be under the control of a GSK3beta-independent mechanism that required Axin's RGS (zeige PITX2 Proteine) domain function.

  2. analysis of differential role of Axin RGS (zeige PITX2 Proteine) domain function in Wnt (zeige WNT2 Proteine) signaling during anteroposterior patterning and maternal axis formation

  3. Wnt (zeige WNT2 Proteine)/Axin/beta-catenin (zeige CTNNB1 Proteine) pathway has a role in ventral CNS development

  4. Overactivation of Wnt (zeige WNT2 Proteine)/Axin1/beta-catenin (zeige CTNNB1 Proteine) signaling during late gastrulation leads to bilateral epithalamic expression of Nodal pathway genes independently of lateral plate mesoderm Nodal signaling.

  5. A dorsalization pathway that is exerted by Axin/JNK (zeige MAPK8 Proteine) signaling and its inhibitor Aida (zeige AIDA Proteine) during vertebrate embryogenesis, is defined.

  6. Dab2 (zeige DAB2 Proteine) stabilizes Axin and attenuates Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling by preventing PP1 (zeige PPYR1 Proteine) from binding Axin

AXIN1 Protein Überblick

Protein Überblick

This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene.

Alternative names and synonyms associated with AXIN1

  • axin 1 (AXIN1)
  • axin 1 (axin1)
  • axin 1 (LOC100226467)
  • axin (axin1)
  • axin 1 (Axin1)
  • AI316800 Protein
  • Axin Protein
  • AXIN1 Protein
  • AXIN1-RGS Protein
  • Fu Protein
  • fused Protein
  • Kb Protein
  • Ki Protein
  • kinky Protein
  • knobbly Protein
  • LOC100226467 Protein
  • PPP1R49 Protein
  • wu:fi22e03 Protein
  • wu:fj14c08 Protein
  • wu:fk11b03 Protein
  • xAxin Protein
  • zgc:109872 Protein

Bezeichner auf Proteinebene für Axin 1 Proteine (AXIN1)

axin 1 , axin 1, isoform 1 , axin-1-like , axin-1 , xAxin , axis inhibition protein 1 , axis inhibitor 1 , fused, mouse, homolog of , protein phosphatase 1, regulatory subunit 49 , protein Fused , GSK-3beta interacting protein rAxin , rAxin , masterblind , mbl

GENE ID SPEZIES
453789 Pan troglodytes
734298 Xenopus laevis
100137557 Papio anubis
100226467 Taeniopygia guttata
100392475 Callithrix jacchus
100424087 Macaca mulatta
398097 Xenopus laevis
100065116 Equus caballus
8312 Homo sapiens
490099 Canis lupus familiaris
504357 Bos taurus
12005 Mus musculus
79257 Rattus norvegicus
100718536 Cavia porcellus
395786 Gallus gallus
57931 Danio rerio
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