Ectodysplasin A Proteine (EDA)

Bezeichnung:
Ectodysplasin A Proteine (EDA)
Auf www.antikoerper-online.de finden Sie aktuell 15 Ectodysplasin A (EDA) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Ectodysplasin A Antikörper (105) und Ectodysplasin A Kits (14) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 141 Ectodysplasin A Produkte verfügbar.
Synonyme:
0610040D20Rik, 2900052N06Rik, c11orf5, ECTD1, ED1, ED1-A1, ED1-A2, Eda-A1, Eda-A2, EDA1, EDA2, HED, HED1, mED1, ODT1, RGD1563178, si:ch73-223d24.5, STHAGX1, Ta, tabby, XHED, XLHED
alle Proteine anzeigen Gen GeneID UniProt
EDA 66070 Q9JHS9
EDA 1896 Q92838
Ratte EDA EDA 302424  

Weitere Synonyme anzeigen

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Weitere Proteine zu Ectodysplasin A Interaktionspartnern

Mouse (Murine) Ectodysplasin A (EDA) Interaktionspartner

  1. Data suggest that corneal epithelial integrity is defective and the thickness is reduced in Eda mutant Tabby mice at early postnatal stage (4-week-old); corneal epithelial cell proliferation is decreased and epithelial wound healing (zeige EGFR Proteine)is delayed in Tabby mice, (zeige EGFR Proteine) whereas it is restored by exogenou (zeige EGFR Proteine)s Eda. Tabby mice are a model for X-linked hypohidrotic ectodermal dysplasia and can be treated with recombinant Eda.

  2. Murine nasal submucosal glands express EDA during embryonic development. EDA signalling is essential for Lateral Nasal Gland and Medial Nasal Gland budding and ductal morphogenesis.

  3. Mouse models with HED also carry Eda, Edar (zeige EDAR Proteine) or Edaradd (zeige EDARADD Proteine) mutations and have defects that map to the same structures.We report that otitis media, rhinitis and nasopharyngitis occur at high frequency in Eda and Edar (zeige EDAR Proteine) mutant mice and explore the pathogenic mechanisms related to glandular function, microbial and immune parameters in these lines

  4. Wnt (zeige WNT2 Proteine), Eda, and Shh (zeige SHH Proteine) have roles in touch dome Merkel cell development

  5. Using an ex vivo culture system, we show that suppression of canonical Wnt (zeige WNT2 Proteine) signalling leads to a dose-dependent inhibition of supernumerary placodes in K14 (zeige KRT14 Proteine)-Eda tissue explants.

  6. Eda and activin A (zeige INHBA Proteine) are upstream regulators of Foxi3 (zeige FOXI3 Proteine) in skin appendage placodes

  7. Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 (zeige FGF20 Proteine) signaling.

  8. NF-kappaB (zeige NFKB1 Proteine) downstream of the TNF (zeige TNF Proteine)-like ligand ectodysplasin (Eda) is identified as a unique regulator of embryonic and prepubertal ductal morphogenesis.

  9. Data found that Eda regulates growth and branching of the SMG (zeige SNRPG Proteine) via transcription factor NF-kappaB (zeige NFKB1 Proteine) in the epithelium, and that the hedgehog (zeige SHH Proteine) pathway is an important mediator of Eda/NF-kappaB (zeige NFKB1 Proteine).

  10. Dkk4 (zeige DKK4 Proteine) affects an auxiliary pathway for Eda-independent development of secondary hair

Human Ectodysplasin A (EDA) Interaktionspartner

  1. Data suggest that EDA is highly expressed in meibomian glands and is detectible in human tears but not serum; EDA protein is secreted from meibomian glands and promotes corneal epithelial cell proliferation through regulation of EGFR (zeige EGFR Proteine) signaling pathway. (EGFR (zeige EGFR Proteine) = epidermal growth factor receptor (zeige EGFR Proteine))

  2. EDA is an important candidate gene for two developmental diseases sharing the common feature of the congenital lack of teeth. In addition, these results can support the hypothesis that X-linked HED and EDA-related NTA are the same disease with different degrees of severity.

  3. EDA-A2 and its receptor XEDAR (zeige EDA2R Proteine) are overexpressed in epithelial cells of salivary glands in Sjogren's syndrome patients, in comparison with healthy individuals. The EDA-A2/XEDAR (zeige EDA2R Proteine) system in these cells is involved in the induction of apoptosis via CASP3 (zeige CASP3 Proteine) activation.

  4. Based on a computerized protein structure analysis, we suggest that the change p.Arg289His in EDA impairs protein stabilization and thus might possibly be involved in the development of oligodontia concomitant with a mild ED phenotype.

  5. we identified a novel and three reported EDA missense mutations in four of six patients with X-linked hypohidrotic ectodermal dysplasia. Missense mutations and the mutations affecting the tumor necrosis factor (zeige TNF Proteine) homology domain were correlated with fewer missing teeth.

  6. Our findings indicate that a novel mutation (c.878T>G) of EDA is associated with XLHED and adds to the repertoire of EDA mutations.

  7. We found a novel missense mutation in exon 1 of the EDA1 gene in a putative Mayan family from Mexico with XL-HED.

  8. A novel missense mutation in the EDA gene in a Chinese family with X-linked hypohidrotic ectodermal dysplasia.

  9. dentified a novel deletion mutation located in exon 1 which if expressed would produce a highly truncated protein in a Chinese Han family with X-linked hypohidrotic ectodermal dysplasia

  10. novel non-synonymous mutation in ectodysplasin A (EDA) associated with non-syndromic X-linked dominant congenital tooth agenesis

Cow (Bovine) Ectodysplasin A (EDA) Interaktionspartner

  1. Authors identifya mutation, never described before, that changes the regulation of alternative splicing in the EDA gene and causes ectodermal dysplasia in cattle.

  2. The 161-bp-long LINE1-derived-pseudoexon introduces a shift in reading frame and a premature stop codon early in EDA exon 2 and is probably the cause of XHED in this Danish Red Holstein family.

  3. describe a novel mutation of the EDA gene in which a 19 bp deletion in exon 1 in male Holstein calves demonstrated the phenotypic features of EDA

Zebrafish Ectodysplasin A (EDA) Interaktionspartner

  1. Eda and edar (zeige EDAR Proteine) are not required for early development but are specific for the development of adult skeletal and dental structures.

Ectodysplasin A (EDA) Protein Überblick

Protein Überblick

The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.

Alternative names and synonyms associated with Ectodysplasin A (EDA)

  • ectodysplasin A (EDA)
  • CWC15 homolog (S. cerevisiae) (Cwc15)
  • ectodysplasin A (eda)
  • ectodysplasin-A (Eda)
  • 0610040D20Rik Protein
  • 2900052N06Rik Protein
  • c11orf5 Protein
  • ECTD1 Protein
  • ED1 Protein
  • ED1-A1 Protein
  • ED1-A2 Protein
  • Eda-A1 Protein
  • Eda-A2 Protein
  • EDA1 Protein
  • EDA2 Protein
  • HED Protein
  • HED1 Protein
  • mED1 Protein
  • ODT1 Protein
  • RGD1563178 Protein
  • si:ch73-223d24.5 Protein
  • STHAGX1 Protein
  • Ta Protein
  • tabby Protein
  • XHED Protein
  • XLHED Protein

Bezeichner auf Proteinebene für Ectodysplasin A Proteine (EDA)

ectodysplasin A , embryonic development factor 1 , nucleoporin , protein CWC15 homolog , spliceosome-associated protein CWC15 homolog , X-linked anhidroitic ectodermal dysplasia protein , ectodysplasin-A , oligodontia 1 , ectodysplasin A1 , ectodermal dysplasia 1, anhidrotic , ectodermal dysplasia protein , ectodysplasin-1 , nackt , nkt , EDA protein homolog

GENE ID SPEZIES
473652 Pan troglodytes
66070 Mus musculus
1896 Homo sapiens
769069 Gallus gallus
491935 Canis lupus familiaris
616179 Bos taurus
798740 Danio rerio
13607 Mus musculus
302424 Rattus norvegicus
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