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promotes assembly and secretion of human apolipoprotein B (zeige APOB Proteine)
the phospholipid transfer activity of MTP is sufficient for the assembly and secretion of primordial apoB (zeige APOB Proteine) lipoproteins
analysis of developmental expression and nutritional regulation of zebrafish homolog to mammalian microsomal triglyceride transfer protein large subunit
In a genetic study of lipid transport and metabolism, larval levels of microsomal triglyceride transfer protein (Mtp), the protein responsible for packaging triacylglycerol and beta-lipoproteins into lipoprotein particles, are unchanged by feeding.
MTTP is regulated by apo A-IV in manner to promote increased packaging of triglyceride into chylomicron core, which may be important in neonatal fat absorption.
There appears to be an interaction between the porcine MTTP genotype and the type of fat source in the pig diet, which would agree with the previous results on the biology of MTTP biology.
Nonesterified fatty acids significantly inhibit the expression of ApoB100 (zeige APOB Proteine), ApoE (zeige APOE Proteine), MTP, and LDLR (zeige LDLR Proteine), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
after calving the apolipoprotein B(100 (zeige APOB Proteine)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP) and apolipoprotein E (zeige APOE Proteine) messenger RNA abundance were higher in the liver
measurements of the transfer of phospholipids (PLs (zeige CTSC Proteine)) and cholesteryl esters (CEs)to acceptor vesicles by purified MTP showed TAG transfer activity was the most robust, and CE and PL transfer activities were 60-71% and 5-13% of the TAG transfer activity
Fasting upregulates Fpn1 (zeige SLC40A1 Proteine) expression in spleen and peritoneal macrophages, probably via a ghrelin (zeige GHRL Proteine)/GHSR1a/MAPK (zeige MAPK1 Proteine) signaling pathway.
Microsomal triglyceride transfer protein protein plays a critical role in lipid droplet maturation, but does not regulate total body fat accumulation.
Expression of Hepcidin (zeige HAMP Proteine) and Ferroportin (zeige SLC40A1 Proteine) in the Placenta, and Ferritin (zeige FTL Proteine) and Transferrin Receptor 1 (zeige TFR Proteine) Levels in Maternal and Umbilical Cord Blood in Pregnant Women with and without Gestational Diabetes
findings show that ferroportin (zeige SLC40A1 Proteine) expression by macrophages at the site of injury represents a requirement for appropriate activation of myogenic precursors and eventual healing of injured skeletal muscle
data provide the first in vivo evidence of the transcriptional regulatory activity of beta-apocarotenoids and identify microsomal triglyceride transfer protein and its transcription factors as the targets of their action. This study demonstrates that beta-carotene induces a feed-forward mechanism in the placenta to enhance the assimilation of beta-carotene for proper embryogenesis.
The results suggest that physiologic hepcidin (zeige HAMP Proteine) levels are insufficient to alter Fpn levels within the retinal pigment epithelium and Muller cells, but may limit iron transport into the retina from vascular endothelial cells.
PHARMACOLOGICAL STUDY OF NEW COMPOUNDS ACTING AS REGULATORS OF 18-KDA TRANSLOCATOR PROTEIN (zeige TSPO Proteine) LIGANDS
In Angiotensin II treated mice, duodenal divalent metal transporter-1 (zeige SLC11A2 Proteine) and ferroportin (zeige SLC40A1 Proteine) expression levels were increased and hepatic hepcidin (zeige HAMP Proteine) mRNA expression and serum hepcidin (zeige HAMP Proteine) concentration were reduced.
Intestine-specific MTP (zeige LAPTM4A Proteine) and global ACAT2 (zeige SOAT2 Proteine) deficiency lowers acute cholesterol absorption with chylomicrons and HDLs (zeige CSF1R Proteine)
Mice infected with Salmonella typhimurium have increased duodenal expression of the iron exporter ferroportin-1 (zeige SLC40A1 Proteine), consistent with increased uptake of dietary iron.
two new hypolipidemic patients with very low plasma triglyceride and apolipoprotein B (apoB (zeige APOB Proteine)) levels with plasma lipid profiles similar to abetalipoproteinemia (ABL (zeige ABL1 Proteine)) patients, are reported.
results of this study, examining a cohort of obese children, suggest that the genetic variation at MTTP rs2306986 was associated with higher susceptibility to NAFLD
Data suggest that amphipathic beta-strands in 200 N-terminal residues of beta1 domain of APOB (zeige APOB Proteine) are required for secretion of lipid-rich or lipid-poor particles; residues 300-700 or 1050-1500 of beta1 domain appear to be required for secretion of lipid-rich particles; MTTP is required for secretion of intact APOB (zeige APOB Proteine) but not of truncated APOB (zeige APOB Proteine). (APOB (zeige APOB Proteine) = apolipoprotein B (zeige APOB Proteine); MTTP = microsomal triglyceride transfer protein)
In chronic hepatitis C patients infected with HCV genotype 3 and with the TT/GT genotype of the MTTP -493G/T SNP, a significant increase in hepatic steatosis was observed, which may indicate that this SNP has a significant influence on the accumulation of triglycerides in hepatocytes.
High expression of MTTP is associated with high carotid intima-media thickness.
MTP (zeige MT1B Proteine) Gene Variants are associated with Homozygous Familial Hypercholesterolemia.
the N-terminal domain of MTP (zeige MT1B Proteine) is important for its lipid transfer activity
These studies indicated that SAP18 (zeige SAP18 Proteine) expression enhanced the recruitment of mSin3A in coordination with TRIB1 (zeige TRIB1 Proteine) to MTTP regulatory elements and increased MTTP expression.
Results present evidence that MTTP polymorphisms could modulate the lipid homeostasis to determine the serum lipids and increase risk of non-alcoholic fatty liver disease.
Findings from meta-analysis indicate that the MTP (zeige MT1B Proteine) -493G/T polymorphism may contribute to the development of non-alcoholic fatty liver disease. Thus, the MTP (zeige MT1B Proteine) -493G/T polymorphism may be a biomarker for the early detection of the disease.
MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.
microsomal triglyceride transfer protein (large polypeptide, 88kDa)
, microsomal triglyceride transfer protein large subunit
, microsomal triglyceride transfer protein B
, microsomal triglyceride transfer protein, large subunit
, microsomal triacylglycerol transfer protein
, microsomal triglyceride transfer protein