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anti-Human GDF2 Antikörper:
anti-Mouse (Murine) GDF2 Antikörper:
anti-Rat (Rattus) GDF2 Antikörper:
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Human Polyclonal GDF2 Primary Antibody für IHC (p), WB - ABIN388817
Herrera, van Dinther, Ten Dijke, Inman: Autocrine bone morphogenetic protein-9 signals through activin receptor-like kinase-2/Smad1/Smad4 to promote ovarian cancer cell proliferation. in Cancer research 2009
Show all 5 Pubmed References
Human Polyclonal GDF2 Primary Antibody für ELISA - ABIN449713
Scharpfenecker, van Dinther, Liu, van Bezooijen, Zhao, Pukac, Löwik, ten Dijke: BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis. in Journal of cell science 2007
Human Polyclonal GDF2 Primary Antibody für WB - ABIN4256550
David, Mallet, Keramidas, Lamandé, Gasc, Dupuis-Girod, Plauchu, Feige, Bailly: Bone morphogenetic protein-9 is a circulating vascular quiescence factor. in Circulation research 2008
The results demonstrate that although BMP9 alone does not influence leukocyte recruitment, it primes the vascular endothelium to mount a more intense response when challenged with LPS (zeige IRF6 Antikörper) through an increase in TLR4 (zeige TLR4 Antikörper), E-selectin (zeige SELE Antikörper), and VCAM-1 (zeige VCAM1 Antikörper) and ultimately through enhanced leukocyte recruitment.
Data suggest BMP9/GDF2 and BMP10 (zeige BMP10 Antikörper) synergize with TNFA (zeige TNF Antikörper) to increase monocyte recruitment to vascular endothelial cells; process appears to be mediated mainly via ALK2/ACVR1 (zeige ACRV1 Antikörper) (which exhibits protein kinase (zeige CDK7 Antikörper) activity). These studies used in vitro flow monocyte adhesion assay. (BMP9 = growth differentiation factor 2; BMP10 (zeige BMP10 Antikörper) = bone morphogenetic protein 10 (zeige BMP10 Antikörper); TNFA (zeige TNF Antikörper) = tumor necrosis factor alpha (zeige TNF Antikörper); ALK2/ACVR1 (zeige ACRV1 Antikörper) = activin A receptor type 1 (zeige ACRV1 Antikörper))
These results suggest that BMP9-transduced calvarial mesenchymal progenitor cells seeded in a PPCN-g thermoresponsive scaffold is capable of inducing bone formation in vivo and is an effective means of creating tissue engineered bone for critical sized defects.
circulating levels significantly decreased in type 2 diabetes mellitus patients and associated with glucose homoeostasis and insulin (zeige INS Antikörper) sensitivity
the data identify MxA (zeige MX1 Antikörper) as a novel stimulator of BMP4 (zeige BMP4 Antikörper) and BMP9 transcriptional signaling, and suggest it to be a candidate IFN-alpha (zeige IFNA Antikörper)-inducible mechanism that might have a protective role against development of pulmonary arterial hypertension and other vascular diseases.
BMP9 inhibited the proliferation and migration of the A549 cells.
his study shows that BMP9 inhibition is associated with Osteosarcoma (OS) development and that enhanced expression of BMP9 may be a potential treatment method for OS
IGF1 (zeige IGF1 Antikörper) can enhance BMP9-induced osteogenic differentiation in mesenchymal stem cells.
In ovarian and breast epithelial cells, epigenetic regulation of GDF2 suppresses anoikis.
BMP9 also influenced the expression of PPARgamma (zeige PPARG Antikörper).
Our findings provide a clearer understanding of the cellular pathways utilized by BMP-9 for chondrogenesis that may help improve current therapies for regenerative cartilage repair.
Constitutive expression of low levels of BMP-9 stabilises hepatocyte function in the healthy liver. High levels of BMP-9 cause enhanced damage upon acute or chronic injury.
Notch (zeige NOTCH1 Antikörper) signaling may play an important role in BMP9-induced osteogenesis and angiogenesis. It's conceivable that simultaneous activation of the BMP9 and Notch (zeige NOTCH1 Antikörper) pathways should efficiently couple osteogenesis and angiogenesis of MSCs for successful bone tissue engineering.
Western blot analysis demonstrated that following BMP2 (zeige BMP2 Antikörper) and BMP7 (zeige BMP7 Antikörper) cotransfection of MC3T3E1 cells, the protein expression levels of BMP2 (zeige BMP2 Antikörper), BMP4 (zeige BMP4 Antikörper), BMP6 (zeige BMP6 Antikörper), BMP7 (zeige BMP7 Antikörper), BMP9 and Wnt3a (zeige WNT3A Antikörper) were increased compared with control cells
he results of the present study demonstrated that BMP9 promoted the osteoclast differentiation of osteoclast precursors via binding to the ALK1 (zeige ACVRL1 Antikörper) receptor on the cell surface, and inhibiting the ERK1/2 (zeige MAPK1/3 Antikörper) signaling pathways in the cell
that Dkk1 (zeige DKK1 Antikörper) negatively regulates BMP9-induced osteogenic differentiation.
Data show athat beta-catenin (zeige CTNNB1 Antikörper) can be activated by bone morphogenetic protein 9 (BMP9) and the activation of beta-catenin (zeige CTNNB1 Antikörper) plays an important role in the differentiation of C3H10T1/2 cells into cardiomyocyte-like cells induced by BMP9.
miR23b inhibits BMP9induced C2C12 myoblast osteogenesis via targeting of the Runx2 (zeige RUNX2 Antikörper) gene, acting as a suppressor.
We have established a producer line that stably expresses a high level of active BMP9 protein. Such producer line should be a valuable resource for generating biologically active BMP9 protein for studying BMP9 signaling
Data show that microRNA miR (zeige MLXIP Antikörper)-21 was significantly upregulated by bone morphogenetic protein 9 (BMP9) during the osteogenesis the multilineage cells (MMCs) by suppressing Smad7 (zeige SMAD7 Antikörper) protein.
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons.
bone morphogenetic protein 9
, growth/differentiation factor 2