anti-UNC93B1 (UNC93B1) Antikörper

anti-Unc-93 Homolog B1 (C. Elegans) Antikörper (UNC93B1)
Auf finden Sie aktuell 29 Unc-93 Homolog B1 (C. Elegans) (UNC93B1) Antikörper von 15 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 35 UNC93B1 Produkte verfügbar.
IIAE1, Unc-93B1, UNC93, Unc93b
Alle Antikörper anzeigen Gen GeneID UniProt
UNC93B1 81622 Q9H1C4
UNC93B1 54445 Q8VCW4
UNC93B1 361689  

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Meistgesuchte Reaktivitäten zu anti-UNC93B1 (UNC93B1) Antikörper

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anti-Human UNC93B1 Antikörper:

anti-Mouse (Murine) UNC93B1 Antikörper:

anti-Rat (Rattus) UNC93B1 Antikörper:

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Am meisten referenzierte anti-UNC93B1 Antikörper

  1. Human Polyclonal UNC93B1 Primary Antibody für WB - ABIN4364376 : Nakano, Morimoto, Suzuki, Watanabe, Amano, Takasaki: Up-regulation of the endoplasmic reticulum transmembrane protein UNC93B in the B cells of patients with active systemic lupus erythematosus. in Rheumatology (Oxford, England) 2010 (PubMed)
    Zeige alle 2 Referenzen für 4364376

  2. Human Polyclonal UNC93B1 Primary Antibody für IHC, ELISA - ABIN1003411 : Brinkmann, Spooner, Hoebe, Beutler, Ploegh, Kim: The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. in The Journal of cell biology 2007 (PubMed)
    Zeige alle 2 Referenzen für 1003411

  3. Cow (Bovine) Polyclonal UNC93B1 Primary Antibody für WB - ABIN2783996 : Kanerva, Moilanen, Virolainen, Vaheri, Pitkäranta: Melkersson-Rosenthal syndrome. in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2008 (PubMed)

Weitere Antikörper gegen UNC93B1 Interaktionspartner

Human Unc-93 Homolog B1 (C. Elegans) (UNC93B1) Interaktionspartner

  1. Endosomal localization of endogenous TLR3 (zeige TLR3 Antikörper) was decreased by silencing of LRRC59, suggesting that LRRC59 promotes UNC93B1-mediated translocation of NA-sensing TLRs from the ER upon infection.

  2. the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms.

  3. IgM(+)IgD(+)CD27 (zeige CD27 Antikörper)(+) but not switched B cells were strongly reduced in MYD88 (zeige MYD88 Antikörper)-, IRAK-4 (zeige IRAK4 Antikörper)-, and TIRAP (zeige TIRAP Antikörper)-deficient patients, but not UNC-93B-deficient patients.

  4. TLR3 (zeige TLR3 Antikörper) is the important regulator of UNC93B1 that in turn governs the responsiveness of all TLR3 (zeige TLR3 Antikörper) as the important regulator of UNC93B1 that in turn governs the responsiveness of all NAS (zeige SCN9A Antikörper) Toll (zeige TLR4 Antikörper)-like receptors

  5. UNC93B1 expression is required for TLR3 (zeige TLR3 Antikörper) cleavage and signaling.

  6. UNC93B1 physically associates with human TLR8 (zeige TLR8 Antikörper) and regulates TLR8 (zeige TLR8 Antikörper)-mediated signaling

  7. findings elucidate a genetic etiology for herpes simplex virus encephalitis in two children with autosomal recessive deficiency in the intracellular protein (zeige CKAP2 Antikörper) UNC-93B, resulting in impaired cellular interferon-alpha (zeige IFNA Antikörper)/beta and -lambda antiviral responses

  8. No UNC-93B1 mutations were foundin patients with MRS.

  9. IRAK-4 (zeige IRAK4 Antikörper)-, MyD88 (zeige MYD88 Antikörper)-, and UNC-93B-deficient patients did not display autoreactive antibodies in their serum or develop autoimmune diseases, suggesting that IRAK-4 (zeige IRAK4 Antikörper), MyD88 (zeige MYD88 Antikörper), and UNC-93B pathway blockade may thwart autoimmunity in humans.

  10. regulates ligand-induced trafficking of TLR7 (zeige TLR7 Antikörper) and TLR9 (zeige TLR9 Antikörper) from the ER to endolysosomes, potential therapeutic target for controlling dysregulated TLR7 (zeige TLR7 Antikörper)/9 responses in autoimmune diseases

Mouse (Murine) Unc-93 Homolog B1 (C. Elegans) (UNC93B1) Interaktionspartner

  1. Autophagy contributes to macrophage resistance to Leishmania major. Data, including data from studies in knockout mice, suggest a key resistance mechanism involves endosomal signaling via Tlr3 (zeige TLR3 Antikörper)/7/9 in macrophages; macrophages deficient for Tlr3 (zeige TLR3 Antikörper)/7/9, Unc93b1, or MyD88 (zeige MYD88 Antikörper) fail to undergo L. major-induced autophagy. (TLR = Toll (zeige TLR4 Antikörper)-like receptor; Unc93b1 = unc-93 homolog B1; MyD88 (zeige MYD88 Antikörper) = myeloid differentiation primary response gene 88 (zeige MYD88 Antikörper))

  2. Describe a mechanism for differential sorting of endosomal toll (zeige TLR4 Antikörper) like receptors by UNC93B1.

  3. These observations establish a significant role for Unc93b1 in the regulation of the host inflammatory response to CVB3 infection and also reveal potential mediators of host tissue damage that merit further investigation in acute viral myocarditis.

  4. Unc93b1 controls activation of both myeloid and lymphoid cells during the innate immune response to influenza.

  5. We discovered that TLR5 (zeige TLR5 Antikörper), a cell surface receptor for bacterial protein flagellin (zeige FliC Antikörper), also requires UNC93B1 for plasma membrane localization and signaling.

  6. The observations demonstrate for the first time that activation of interferon (zeige IFNA Antikörper) and estrogen signaling in immune cells up-regulates the expression of murine Unc93b1.

  7. Mutation of the acidic residues in TLR3 (zeige TLR3 Antikörper) and TLR9 (zeige TLR9 Antikörper) prevents UNC93B1 binding, and impairs TLR trafficking and renders the mutant receptors incapable of transmitting signals; therefore, the acidic residues in the juxtamembrane region of the nucleotide-sensing TLRs have important functional roles

  8. Data indicate that UNC93B1 mutant and triple TLR3 (zeige TLR3 Antikörper)/7/9 knock-out mice are highly susceptible to infection with Leishmania major.

  9. UNC93B1 mediates innate inflammation and antiviral defense in the liver during acute murine cytomegalovirus infection.

  10. UNC93B, but not Toll (zeige TLR4 Antikörper)-like receptors 3, 7, and 9, is required for bacterial RNA-induced IL-1beta (zeige IL1B Antikörper) production and activation of caspase-1 (zeige CASP1 Antikörper).

UNC93B1 Antigen-Profil

Beschreibung des Gens

This gene encodes a protein with similarity to the C. elegans unc93 protein. The Unc93 protein is involved in the regulation or coordination of muscle contraction in the worm.

Alternative names and synonyms associated with UNC93B1

  • unc-93 homolog B1 (C. elegans) (UNC93B1) Antikörper
  • unc-93 homolog B1 (UNC93B1) Antikörper
  • unc-93 homolog B1 (C. elegans) (Unc93b1) Antikörper
  • IIAE1 Antikörper
  • Unc-93B1 Antikörper
  • UNC93 Antikörper
  • Unc93b Antikörper

Bezeichner auf Proteinebene für UNC93B1

unc-93 homolog B1 (C. elegans) , protein unc-93 homolog B1 , unc-93 related protein , hUNC93B1 , unc93 homolog B , unc93 homolog B1 , unc-93 homolog B

483692 Canis lupus familiaris
710928 Macaca mulatta
100059773 Equus caballus
100582643 Nomascus leucogenys
746130 Pan troglodytes
395244 Gallus gallus
81622 Homo sapiens
508878 Bos taurus
54445 Mus musculus
361689 Rattus norvegicus
Ausgewählte Anbieter für anti-UNC93B1 (UNC93B1) Antikörper
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