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Fish IRF6 (zeige IRF6 ELISA Kits) is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 (zeige MYD88 ELISA Kits) and TBK1, suggesting that differences in the IRF6 (zeige IRF6 ELISA Kits) regulation pattern exist between lower and higher vertebrates.
ZIKV infection of neuroepithelial stem cells and radial glial cells causes centrosomal depletion and mitochondrial sequestration of phospho-TBK1 during mitosis.
High TBK1 expression is associated with Lung cancer.
Our results highlight an unexpected role of the Golgi apparatus in innate immunity as a key subcellular gateway for TBK1 activation after RNA virus infection.
The results of this study proposed that TBK1 is not a frequent causal gene in Chinese ALS patients.
HERP (zeige HERPUD1 ELISA Kits) Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress
these data suggest that HNSs, an antagonist of host innate immunity, interacts with TBK1 and thereby hinders the association of TBK1 with its substrate IRF3 (zeige IRF3 ELISA Kits), thus blocking IRF3 (zeige IRF3 ELISA Kits) activation and transcriptional induction of the cellular antiviral responses.
Pathogenic variants in TBK1 are rare but could be responsible for sALS (zeige CDH23 ELISA Kits) in a small number of Korean patients.
High TBK1 expression is associated with normal tension glaucoma.
We identified novel genomic TBK1 variants including two loss-of-function (LoF) (p.Leu59Phefs*16 and c.358+5G>A), two missense (p.Asp118Asn and p.Ile397Thr) and one intronic variant (c.1644-5_1644-2delAATA).
Mutations in the TANK-binding kinase 1 (TBK1) gene were identified as a cause for amyotrophic lateral sclerosis (ALS (zeige IGFALS ELISA Kits)) with or without comorbid frontotemporal dementia.
The TBK1 Y179A mutant failed to rescue type I IFN production by virally infected RAW264.7 macrophages deficient in TBK1
these studies reveal an additional regulatory function of TRIM8 (zeige TRIM8 ELISA Kits) in innate immune responses: TRIM8 (zeige TRIM8 ELISA Kits) catalyzes polyubiquitination of TRIF (zeige RNF138 ELISA Kits), resulting in disruption of TRIF (zeige RNF138 ELISA Kits)-TBK1 interaction
TBK1 regulates p16 expression and retinal ganglion cell senescence.
USP38 inhibits type I interferon signaling by editing TBK1 ubiquitination through NLRP4 signalosome.
The authors report that Raf kinase inhibitory protein (RKIP (zeige PEBP1 ELISA Kits)) is essential for TBK1 activation and type I interferon (zeige IFNA ELISA Kits) production triggered by viral infection.
Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 (zeige FOSL1 ELISA Kits) "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3 (zeige TRAF3 ELISA Kits)), TIR domain-containing adapter inducing IFN-beta (zeige IFNB1 ELISA Kits) (TRIF (zeige RNF138 ELISA Kits)), and Tank-binding kinase 1 (TBK1) via impairing K63-linked polyubiquitination of TRAF3 (zeige TRAF3 ELISA Kits) and TRIF (zeige RNF138 ELISA Kits).
TBK1 complexes required for the phosphorylation of IRF3 (zeige IRF3 ELISA Kits) and the production of interferon-beta (zeige IFNB1 ELISA Kits) have been identified.
this study reveals a previously unknown ICOS (zeige ICOS ELISA Kits)-TBK1 signaling pathway that specifies the commitment of germinal center follicular helper T cells
Innate immune responses to adenovirus vectors are largely TBK1-dependent in the spleen but TBK1-independent in the liver
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors.
serine/threonine-protein kinase TBK1
, TANK-binding kinase 1
, NF-kappa-B-activating kinase
, TANK binding kinase 1
, serine/threonine protein kinase TBK1
, serine/threonine-protein kinase TBK1-like
, NF-kB-activating kinase