anti-Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) Antikörper

anti-Inositol Polyphosphate-5-Phosphatase, 145kDa Antikörper (INPP5D)
Auf finden Sie aktuell 146 Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) Antikörper von 19 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Inositol Polyphosphate-5-Phosphatase, 145kDa Kits (16) und Inositol Polyphosphate-5-Phosphatase, 145kDa Proteine (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 174 Inositol Polyphosphate-5-Phosphatase, 145kDa Produkte verfügbar.
13.t00027, 256.t00004, AI323613, hp51CN, INPP5D, s-SHIP, SHIP, SHIP-1, SHIP1, SIP-145

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Am meisten referenzierte anti-Inositol Polyphosphate-5-Phosphatase, 145kDa Antikörper

  1. Human Monoclonal INPP5D Primary Antibody für FACS, WB - ABIN302081 : Ai, Maturu, Johnson, Wang, Marsh, Tridandapani: The inositol phosphatase SHIP-2 down-regulates FcgammaR-mediated phagocytosis in murine macrophages independently of SHIP-1. in Blood 2006 (PubMed)
    Zeige alle 4 Referenzen für 302081

  2. Human Monoclonal INPP5D Primary Antibody für EIA, WB - ABIN238500 : Xing, Hamaguchi: Effects of SHIP-1 on MMP2 secretion and invasion of SR3Y1 cells. in Journal of genetics and genomics = Yi chuan xue bao 2007 (PubMed)
    Zeige alle 4 Referenzen für 238500

  3. Mouse (Murine) Monoclonal INPP5D Primary Antibody für IF, WB - ABIN968479 : Lioubin, Algate, Tsai, Carlberg, Aebersold, Rohrschneider: p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity. in Genes & development 1996 (PubMed)
    Zeige alle 3 Referenzen für 968479

  4. Human Polyclonal INPP5D Primary Antibody für EIA, WB - ABIN358021 : Gilby, Goodeve, Winship, Valk, Delwel, Reilly: Gene structure, expression profiling and mutation analysis of the tumour suppressor SHIP1 in Caucasian acute myeloid leukaemia. in Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007 (PubMed)
    Zeige alle 3 Referenzen für 358021

  5. Human Polyclonal INPP5D Primary Antibody für ELISA, WB - ABIN1531473 : Ware, Rosten, Damen, Liu, Humphries, Krystal: Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation. in Blood 1996 (PubMed)

Weitere Antikörper gegen Inositol Polyphosphate-5-Phosphatase, 145kDa Interaktionspartner

Zebrafish Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) Interaktionspartner

Mouse (Murine) Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) Interaktionspartner

  1. Rictor (zeige RICTOR Antikörper) positively regulates B cell receptor signaling via up-regulating Btk (zeige BTK Antikörper) and down-regulating SH2-containing inositol phosphatase

  2. MiR (zeige MLXIP Antikörper)-155 promotes experimental colitis by repressing SHIP-1 expression.

  3. Results are consistent with predicted/observed reduction in the Lyn-SHIP-1-PTEN-SHP-1 axis function in B cells from systemic lupus

  4. SHIP has a role in extracellular matrix accumulation via suppressing PI3K/Akt (zeige AKT1 Antikörper)/CTGF (zeige CTGF Antikörper) signaling in diabetic kidney dise

  5. this study shows that FcgammaRIIb drives the sequential dephosphorylation system comprising SHIP1/2 and Inpp4a (zeige INPP4A Antikörper), and accelerates phagosome acidification

  6. Data (including data from studies in knockout mice) suggest that up-regulation of signaling in colonic mucosa via interleukin-10 (zeige IL10 Antikörper)/microRNA-155/SHIP-1 (Src homology 2 domain-containing inositol-5-phosphatase) is involved in development of colitis due to dysbiosis.

  7. Our results describe a critical role for SHIP-1 in regulating the ability of dendritic cells to efficiently prime Th2-type responses.

  8. Findings indicate a role for inositol-polyphosphate 5-phosphatase SHIP-1 coupling to DC-type lectin receptor ectin-1 hemITAM in the selective control of downstream responses.

  9. miR (zeige MLXIP Antikörper)-155 regulates the delicate balance between PAK1 (zeige PAK1 Antikörper)-mediated proliferation and apoptosis in T cells impacting lymphoid organ size and function.

  10. miR (zeige MLXIP Antikörper)-155 regulation of SHIP represents a unique axis that regulates dendritic cells function in vivo.

Human Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) Interaktionspartner

  1. JARID1B (zeige KDM5B Antikörper) directly bound to PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper) signaling inhibitor SHIP1 gene promoter and decreased SHIP1 gene expression.

  2. Study shows that SHIP1 activity is decreased in adult Crohn's disease (CD) patients either through reduced intrinsic enxymatic activity or reduced protein expression, and propose that in addition to ATG16L1 (zeige ATG16L1 Antikörper), SHIP1 may contribute to the risk conferred by the 2q37 CD risk locus.

  3. results indicate that FcgammaRIIB is not uniquely able to promote membrane recruitment of SHIP, but rather modulates its function via formation of distinct signaling complexes. Membrane recruitment of SHIP via Syk (zeige SYK Antikörper)-dependent mechanisms may be an important factor modulating immunoreceptor signaling.

  4. SHIP has a role in extracellular matrix accumulation via suppressing PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper)/CTGF (zeige CTGF Antikörper) signaling in diabetic kidney dise

  5. SHIP levels and activity are lower in intestinal tissues and peripheral blood samples from patients with Crohn's disease, resulting in induction of Il1-beta (zeige IL1B Antikörper).

  6. Underexpression of SHIP1 is associated with drug resistance in acute myeloid leukemia (zeige BCL11A Antikörper).

  7. ectopically expressed SHIP1 accumulates in nucleolar cavities and colocalizes with the tumor suppressor protein p53 (zeige TP53 Antikörper).

  8. Results show that expression of SHIP1 protein is targeted by miR (zeige MLXIP Antikörper)-155 in acute myeloid leukemia (zeige BCL11A Antikörper) (AML (zeige RUNX1 Antikörper)) suggesting it as an onco-miR (zeige MLXIP Antikörper). The miR (zeige MLXIP Antikörper)-155/SHIP1/PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper) signaling pathway could play an important role in the pathogenesis of AML (zeige RUNX1 Antikörper).

  9. Overexpression of miR (zeige MLXIP Antikörper)-155 in the gouty synovial fluid mononuclear cells leads to suppress SHIP-1 levels and enhance proinflammatory cytokines.

  10. SLAMF7 (zeige SLAMF7 Antikörper)-triggered inhibition is mediated by a mechanism involving Src (zeige SRC Antikörper) kinases, CD45 (zeige PTPRC Antikörper), and SHIP-1 that is defective in MM cells

Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) Antigen-Profil

Beschreibung des Gens

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative names and synonyms associated with Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D)

  • inositol polyphosphate-5-phosphatase, 145kDa (INPP5D) Antikörper
  • inositol polyphosphate-5-phosphatase, 145kDa (inpp5d) Antikörper
  • inositol polyphosphate 5-phosphatase (EHI_159880) Antikörper
  • inositol polyphosphate 5-phosphatase (EHI_153490) Antikörper
  • phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (inpp5d) Antikörper
  • Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (ship1) Antikörper
  • inositol polyphosphate-5-phosphatase D (Inpp5d) Antikörper
  • 13.t00027 Antikörper
  • 256.t00004 Antikörper
  • AI323613 Antikörper
  • hp51CN Antikörper
  • INPP5D Antikörper
  • s-SHIP Antikörper
  • SHIP Antikörper
  • SHIP-1 Antikörper
  • SHIP1 Antikörper
  • SIP-145 Antikörper

Bezeichner auf Proteinebene für INPP5D

inositol polyphosphate-5-phosphatase, 145kDa , SH2 containing inositol phosphatase , phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 , phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1-like , SH2 domain-containing inositol 5'-phosphatase 1 , SH2 domain-containing inositol phosphatase 1 , SH2 domain-containing inositol-5'-phosphatase 1 , SHIP-1 , phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 , Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 , SH2 containing inositol phosphotase , SH2-containing inositol phosphatase SHIP , SIP-145 , Src homology 2 domain-containing inositol-5-phosphatase , inositol polyphosphate-5-phosphatase of 145 kDa , inositol polyphosphate-5-phosphatase, 145 kDa , p150Ship , Inositol polyphosphate-5-phosphatase 145 kDa , Inositol polyphosphate-5-phosphatase, 145 kDa , signaling inositol polyphosphate 5 phosphatase SIP-145

424745 Gallus gallus
470683 Pan troglodytes
507329 Bos taurus
100021361 Monodelphis domestica
100400043 Callithrix jacchus
100446045 Pongo abelii
100464150 Ailuropoda melanoleuca
559103 Danio rerio
3404260 Entamoeba histolytica HM-1:IMSS
3410671 Entamoeba histolytica HM-1:IMSS
100064896 Equus caballus
100526019 Sus scrofa
100561031 Anolis carolinensis
399051 Xenopus laevis
100380693 Salmo salar
16331 Mus musculus
54259 Rattus norvegicus
3635 Homo sapiens
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