Gephyrin Proteine (GPHN)

Bezeichnung:
Gephyrin Proteine (GPHN)
Auf www.antikoerper-online.de finden Sie aktuell 4 Gephyrin (GPHN) Proteine von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Gephyrin Antikörper (84) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 94 Gephyrin Produkte verfügbar.
Synonyme:
5730552E08Rik, AI662856, BC027112, C230040D23, DKFZp459M0825, Geph, gpgb1, GPH, GPHN, GPHRYN, HKPX1
alle Proteine anzeigen Gen GeneID UniProt
GPHN 10243 Q9NQX3
GPHN 268566 Q8BUV3
Ratte GPHN GPHN 64845 Q03555

Weitere Synonyme anzeigen

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Weitere Proteine zu Gephyrin Interaktionspartnern

Zebrafish Gephyrin (GPHN) Interaktionspartner

  1. duplicated gephyrin genes mediate Moco biosynthesis and control postsynaptic clustering of glycine receptor (zeige GLRB Proteine)

Human Gephyrin (GPHN) Interaktionspartner

  1. these data reveal that IQSEC3 acts together with gephyrin to regulate inhibitory synapse development.

  2. A missense mutation of gephyrin that was unable to synthesize MoCo and activate MoCo-dependent enzymes was identified.

  3. A yin-yang haplotype pattern encompassing gephyrin consists of 284 divergent nucleotide states and both variants vary drastically from their mutual ancestral haplotype, suggesting rapid evolution.

  4. The N-terminal region of GABRA3 (zeige GABRA3 Proteine) and the GlyR beta subunit (zeige POLG Proteine) occupies the same binding site of gephyrin.

  5. Results show that PKC (zeige PRRT2 Proteine)-dependent phosphorylation of GAP43 (zeige GAP43 Proteine) plays a critical role in regulating postsynaptic gephyrin aggregation in developing GABAergic synapses.

  6. Structural exonic microdeletions affecting the GPHN gene constitute a rare genetic risk factor for IGE and other neuropsychiatric disorders by an impairment of the GABAergic inhibitory synaptic transmission.

  7. The enhancement of Cb-induced gephyrin clustering by GTP (zeige AK3 Proteine)-TC10 (zeige RHOQ Proteine) does not depend on the guanine nucleotide exchange activity of Cb but involves an interaction that resembles reported interactions of other small GTPases with their effectors

  8. abnormal accumulations of gephyrin are highly correlated with the neuropathologic diagnosis of Alzheimer disease in 17 AD versus 14 control cases. Furthermore, gephyrin accumulations were specific for AD.

  9. Rare exonic deletions implicate the synaptic organizer Gephyrin (GPHN) in risk for autism, schizophrenia and seizures.

  10. Extracellular signal-regulated kinase and glycogen synthase kinase 3beta regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism

Mouse (Murine) Gephyrin (GPHN) Interaktionspartner

  1. Ablation of gephyrin result in the forebrain-specific loss of postsynaptic gamma2-GABAA (zeige GABRg1 Proteine) receptors, reduces LTP (zeige SCP2 Proteine) and network excitability in the dentate gyrus.

  2. adult mice lacking interleukin-1 receptor 1 (IL-1R1) exhibit increased expression of both the excitatory scaffolding protein postsynaptic density-95 (PSD-95) and inhibitory scaffolding proteingephyrin, respectively, in the hippocampus.

  3. The results demonstrate that formation of GABAergic synapses containing a postsynaptic gephyrin scaffold is crucial for morphological differentiation, synaptic integration, and long-term survival of adult-born granule cells/

  4. Data suggest that KIF5 regulates gephyrin sorting by a mechanism that involves GSK3 activity.

  5. Pin1 (zeige PIN1 Proteine)-dependent signaling represents a mechanism to modulate GABAergic transmission by regulating NL2 (zeige MMEL1 Proteine)/gephyrin interaction.

  6. These results reveal a homeostatic mechanism through which activity regulates the dynamics and function of perisomatic inhibitory synapses, and they identify a CaMKII (zeige CAMK2G Proteine)-dependent phosphorylation site on gephyrin.

  7. study reveals that palmitoylation of gephyrin by DHHC-12 contributes to dynamic and functional modulation of GABAergic synapses

  8. Within this network, collybistin (zeige Arhgef9 Proteine) can adopt open/active and closed/inactive conformations to act as a switchable adaptor that links gephyrin to plasma membrane phosphoinositides.

  9. these findings suggest that gephyrin may be a key factor in BDNF (zeige BDNF Proteine)-dependent GABAAR (zeige GABRG2 Proteine) regulation in the amygdala.

  10. Data suggest that the loss of neurotransmitter receptor (zeige GRIN1 Proteine) clustering at inhibitory synapses causes the early lethality of gephyrin deficient mice.

Gephyrin (GPHN) Protein Überblick

Protein Überblick

This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described\; however, the full-length nature of all transcript variants is not currently known.

Alternative names and synonyms associated with Gephyrin (GPHN)

  • gephyrin (GPHN)
  • gephyrin a (gphna)
  • gephyrin (PTRG_08978)
  • gephyrin (VDBG_00775)
  • gephyrin (Tsp_03043)
  • gephyrin (gphn)
  • gephyrin (Gphn)
  • 5730552E08Rik Protein
  • AI662856 Protein
  • BC027112 Protein
  • C230040D23 Protein
  • DKFZp459M0825 Protein
  • Geph Protein
  • gpgb1 Protein
  • GPH Protein
  • GPHN Protein
  • GPHRYN Protein
  • HKPX1 Protein

Bezeichner auf Proteinebene für Gephyrin Proteine (GPHN)

gephyrin , gephyrin1 , gephyrin-like , gephyrin isoform , putative glycine receptor-tubulin linker protein

GENE ID SPEZIES
100063078 Equus caballus
709677 Macaca mulatta
452976 Pan troglodytes
555470 Danio rerio
6347264 Pyrenophora tritici-repentis Pt-1C-BFP
9530667 Verticillium alfalfae VaMs.102
10900320 Trichinella spiralis
100022949 Monodelphis domestica
100124966 Xenopus (Silurana) tropicalis
100172899 Pongo abelii
100331181 Danio rerio
100396072 Callithrix jacchus
100471953 Ailuropoda melanoleuca
100555683 Anolis carolinensis
779372 Xenopus laevis
428878 Gallus gallus
10243 Homo sapiens
490739 Canis lupus familiaris
535194 Bos taurus
268566 Mus musculus
64845 Rattus norvegicus
100153443 Sus scrofa
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