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Zhx2 is a novel regulator of Mup expression; Zhx2 activates as well as represses expression of target genes
These results indicated that ZHX2 plays a critical role in the proliferation and osteo/odontogenic differentiation of SCAPs.
Data show that Zinc-fingers and homeoboxes 2 (ZHX2) represses nuclear transcription factor Y alpha (zeige NFYA Proteine) (NF-Y)-mediated activation of multidrug resistance 1 (MDR1) transcription.
Data indicate that zinc-fingers and homeoboxes 2 (ZHX2) suppresses glypican 3 (GPC3 (zeige GPC3 Proteine)) transcription by binding with its core promoter.
Two novel markers, rs7840785 (PINX1 (zeige PINX1 Proteine)) and rs7844465 (ZHX2), are significantly associated with carotid intima-media thickness.
Expression of a constitutively active Raf (zeige RAF1 Proteine) transgene enhances lymphoproliferation (zeige FAS Proteine), indicating a role for the Ras-MAPK (zeige MAPK1 Proteine) pathway in linker for activation of T cells (LAT (zeige LAT Proteine))-mediated autoimmune hyperproliferation.
There was no significant difference in high and low percentage of HbF in GG, GA, and AA bearing individuals showing that ZHX2 gene variant has no role in ameliorating the severity of beta-thalassemia major in the South Indian population from Andhra Pradesh.
results demonstrate multiple mechanisms decreasing expression of tumor suppressor gene ZHX2 in Hodgkin lymphoma cell lines
Expression profiling of L-1236 cells following siRNA-mediated knockdown of ZHX2 showed inhibition of genes regulating differentiation and apoptosis, suggesting tumor suppressor activity of ZHX2.
ZHX2, a transcriptional repressor, may participate in globin gene regulation.
NFAT1 (zeige NFAT1 Proteine) protein activation can shift oncogenic Ras/Raf (zeige RAF1 Proteine)/MEK (zeige MDK Proteine)/ERK (zeige EPHB2 Proteine) signaling to acting as a tumor suppressor pathway.
The Zhx2 mutation resulted in a failure to suppress expression of lipoprotein lipase (zeige LPL Proteine), a gene normally silenced in the adult liver.
molecular crosstalk between aberrant expression of Hox (zeige MSH2 Proteine) molecule(s) and activated Raf (zeige RAF1 Proteine) may have a key role in the MLL (zeige MLL Proteine)-fusion-mediated-leukemogenesis
Zhx2 acts as a repressor of Gpc3 (zeige GPC3 Proteine) in the adult liver.
The carboxyl terminus of Angptl4 (zeige ANGPTL4 Proteine) alone is sufficient to suppress angiogenesis, possibly through inhibiting the Raf (zeige RAF1 Proteine)/MEK (zeige MDK Proteine)/ERK1/2 MAP kinase (zeige MAPK1 Proteine) pathway in endothelial cells.
These findings revealed that oxidative stress, inflammation, Ras/Raf/ERK1/2 pathway and apoptosis collectively played a crucial role in the chemopreventive activity of farnesol to inhibit the murine skin tumorigenesis.
evidence presented that ZHX2 & ephrin-B1 cytoplasmic domain can interact & regulate transcription; study identifies ZHX2 as novel regulator of neural progenitor cell maintenance & suggests potential nuclear mechanism of ephrin-B function in the cortex
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family.
zinc fingers and homeoboxes 2
, zinc finger and homeodomain protein 2
, zinc fingers and homeoboxes protein 2
, zinc fingers and homeoboxes protein 2-like
, AFP regulator 1
, alpha-fetoprotein regulator 1
, regulator of AFP
, transcription factor ZHX2
, zinc-fingers and homeoboxes 2
, alpha fetoprotein regulation 1, adult