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Human NANOG Protein expressed in Escherichia coli (E. coli) - ABIN667930
Pan, Pei: Identification of two distinct transactivation domains in the pluripotency sustaining factor nanog. in Cell research 2004
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Here the authors couple mutagenesis with functional and dimerization assays to show that the number of tryptophans within the tryptophan repeat is linked to the strength of homodimerization, Sox2 (zeige SOX2 Proteine) heterodimerization and self-renewal activity.
In mouse model of acute uterine injury, Nanog homebox (NANOG) express (zeige SRY Proteine)ion reached (zeige SOX2 Proteine) a peak at 6 h, while sex-determining (zeige POU5F1 Proteine) region Y-box2 (SOX2) and octamer-binding protein 4 (OCT4) peaked later at 12 h after lipopolysaccharide (LPS) treatment.
NANOG as a key regulator connecting the pluripotency network with constitutive heterochromatin organization in mouse embryonic stem cells.
Data indicate that Nanog homeobox protein (zeige HOXA1 Proteine) is important for the effects of reprogramming media.
Nanog enhances proliferation of fibroblasts through transcriptional regulation of cell cycle inhibitor p27 (zeige CDKN1B Proteine) gene.
The different embryonic stem cells Nanog-expressing populations differ in their differentiation propensities. Nanog upregulation is not well correlated to Oct4 (zeige POU5F1 Proteine), Sox2 (zeige SOX2 Proteine) and Klf4 (zeige KLF4 Proteine) expression, or cell cycle phase.
1After the 32-cell stage, when embryos form the blastocyst cavity, Nanog expression was upregulated mainly in ICM cells while it was repressed in the future primitive endoderm lineage in an FGF signaling-dependent manner in the later stages
Nanog is able to transform normal somatic cells into tumor cells.
NANOG represses mitochondrial oxidative phosphorylation genes, as well as reactive oxygen species generation, and activates fatty acid oxidation to support tumor initiating cell self-renewal and drug resistance.
The cellular reprogramming-promoting function of mitoflashes occurs via the upregulation of Nanog expression.
LGR5 (zeige LGR5 Proteine)-expressing fraction of CD54 (zeige ICAM1 Proteine)+ cells represents gastric cancer CSCs, in which LGR5 (zeige LGR5 Proteine) is closely associated with stemness and EMT (zeige ITK Proteine) core genes
Data show that Nanog homebox (NANOG) but not sex-determining region Y (zeige SRY Proteine)-box2 (SOX2 (zeige SOX2 Proteine)) and octamer-binding protein 4 (OCT4 (zeige POU5F1 Proteine)) expression was overexpressed in the endometrium of women with intrauterine adhesion (IUA).
The NANOG transcription was significantly upregulated by ETV4 (zeige ETV4 Proteine) overexpression.
Collectively, these findings demonstrate a novel role of YBX1 (zeige YBX1 Proteine) in maintaining the stemness of CSCs and metastasis, unveiling YBX1 (zeige YBX1 Proteine) as promising therapeutic target for NSCLC treatments.
the early response of pluripotency genes OCT4 (zeige POU5F1 Proteine) and NANOG to the differentiation-inducing stimuli is mediated by dynamic changes in chromatin marks, while DNA methylation (zeige HELLS Proteine) is acquired in the later stages of neurogenesis.
USP21 specifically regulates the Lys48-linked polyubiquitination and stability of NANOG
Nanog expression is a prognostic biomarkers for triple-negative breast cancer
Stat3 (zeige STAT3 Proteine) was correlated with NANOG-mediated EMT (zeige ITK Proteine).
miR-760 was proved to be functional associated with NANOG via regulating its expression.
SIRT-1 and NANOG are high correlated biological markers for diagnosis and prognosis follow up in patients with adenocarcinoma.
the functional porcine NANOG that is different in chromosomal structure from mouse and human genes is a single exon gene and encodes the functional NANOG protein.
Results demonstrate that Nanog could interact with and activate other pluripotent genes both in porcine fetal fibroblasts and embryos.
Localisation of NANOG, OCT4 (zeige POU5F1 Proteine), and E-CADHERIN (zeige CDH1 Proteine) in porcine pre- and peri (zeige PLIN1 Proteine)-implantation embryos.
analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos
Nanog displayed relatively the same methylation levels between sperm and oocytes
Noggin, a cytokine inhibiting the BMP4 pathway, successfully upregulated the relative expression of NANOG mRNA in the ICM explants with respect to controls.
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT-3'. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity).
ES cell-associated protein 4
, early embryo specific expression NK family
, early embryo specific expression NK-type homeobox protein
, homeobox protein NANOG
, homeobox transcription factor Nanog
, homeobox transcription factor Nanog-delta 48
, homeodomain transcription factor Nanog
, homeobox transcription factor NANOG