Nanog Homeobox Proteine (NANOG)

Auf finden Sie aktuell 21 Nanog Homeobox (NANOG) Proteine von 9 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Nanog Homeobox Antikörper (415) und Nanog Homeobox Kits (11) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 464 Nanog Homeobox Produkte verfügbar.
2410002E02Rik, ecat4, ENK
alle Proteine anzeigen Gen GeneID UniProt
NANOG 71950 Q80Z64
NANOG 79923 Q9H9S0
Ratte NANOG NANOG 414065  

Nanog Homeobox Proteine (NANOG) nach Spezies

Weitere Proteine zu Nanog Homeobox Interaktionspartnern

Mouse (Murine) Nanog Homeobox (NANOG) Interaktionspartner

  1. Otx2 (zeige OTX2 Proteine)-mediated Nanog regulation contributes to the integrity of the embryonic stem cell state and cell lineage specification in preimplantation development (zeige MTA2 Proteine).

  2. Maintenance of pluripotency is regulated by a network of transcription factors coordinated by Oct4 (zeige POU5F1 Proteine), Sox2 (zeige SOX2 Proteine), and Nanog; Trim24 (zeige TRIM24 Proteine) significantly improved efficiency of cellular reprogramming, demonstrating its direct functionality in establishing pluripotency.

  3. studies highlight a new hypoxia-induced pathway in which NANOG activates BNIP3L (zeige BNIP3L Proteine) expression, contributing to autophagy induction in hypoxic tumor cells and their resistance to killing by CTL

  4. Genetic reporters can compromise the behavior of important pluripotency-sustaining positive feedback loops, and induce a bifurcation in the underlying dynamics that gives rise to heterogeneous Nanog expression patterns in reporter cell lines that are not representative of the wild-type; findings help explain the range of published observations of Nanog variability and highlight the problem of measurement in live cells.

  5. Here the authors couple mutagenesis with functional and dimerization assays to show that the number of tryptophans within the tryptophan repeat is linked to the strength of homodimerization, Sox2 (zeige SOX2 Proteine) heterodimerization and self-renewal activity.

  6. In mouse model of acute uterine injury, Nanog homebox (NANOG) express (zeige SRY Proteine)ion reached (zeige SOX2 Proteine) a peak at 6 h, while sex-determining (zeige POU5F1 Proteine) region Y-box2 (SOX2) and octamer-binding protein 4 (OCT4) peaked later at 12 h after lipopolysaccharide (LPS) treatment.

  7. NANOG as a key regulator connecting the pluripotency network with constitutive heterochromatin organization in mouse embryonic stem cells.

  8. Data indicate that Nanog homeobox protein (zeige HOXA1 Proteine) is important for the effects of reprogramming media.

  9. Nanog enhances proliferation of fibroblasts through transcriptional regulation of cell cycle inhibitor p27 (zeige CDKN1B Proteine) gene.

  10. The different embryonic stem cells Nanog-expressing populations differ in their differentiation propensities. Nanog upregulation is not well correlated to Oct4 (zeige POU5F1 Proteine), Sox2 (zeige SOX2 Proteine) and Klf4 (zeige KLF4 Proteine) expression, or cell cycle phase.

Human Nanog Homeobox (NANOG) Interaktionspartner

  1. miR-612 has a suppressive role on hepatocellular carcinoma cell stemness via Sp1/Nanog signaling pathway.

  2. These data reveal an overexpression of NANOG and other markers of pluripotency and stemness in meningiomas.

  3. The NANOG deficiency affected multiple genes, particularly, supressed drug-resistance via down-regulated ABCG2 in Eca109 cells, and caused G1 arrest by down-regulated cyclin D1 (CCND1 (zeige CCND1 Proteine)) expression.

  4. Endogenous Plastic Somatic (ePS) cells in a latent state, i.e. lacking SOX2 (zeige SOX2 Proteine), OCT3/4 (zeige POU5F1 Proteine) and NANOG (SON) expression, in non-diseased breast specimens through immunohistochemical analysis of previously identified ePS-specific biomarkers (CD73(+), EpCAM (zeige EPCAM Proteine)(+) and CD90 (zeige THY1 Proteine)(-)).

  5. Data suggest that C-terminal truncated hepatitis B virus X protein (HBx-DeltaC1) enhances liver cancer stem cell (CSC) properties through Stat3 (zeige STAT3 Proteine)/Nanog cascade, and insight for the therapeutic intervention for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC (zeige FAM126A Proteine)).

  6. Nanog directly repressed transcription of the miR (zeige MLXIP Proteine)-200c and miR (zeige MLXIP Proteine)-200b genes in colon cancer cells, inducing epithelial-mesenchymal transformation.

  7. LGR5 (zeige LGR5 Proteine)-expressing fraction of CD54 (zeige ICAM1 Proteine)+ cells represents gastric cancer CSCs, in which LGR5 (zeige LGR5 Proteine) is closely associated with stemness and EMT (zeige ITK Proteine) core genes

  8. Data show that Nanog homebox (NANOG) but not sex-determining region Y (zeige SRY Proteine)-box2 (SOX2 (zeige SOX2 Proteine)) and octamer-binding protein 4 (OCT4 (zeige POU5F1 Proteine)) expression was overexpressed in the endometrium of women with intrauterine adhesion (IUA).

  9. The NANOG transcription was significantly upregulated by ETV4 (zeige ETV4 Proteine) overexpression.

  10. Collectively, these findings demonstrate a novel role of YBX1 (zeige YBX1 Proteine) in maintaining the stemness of CSCs and metastasis, unveiling YBX1 (zeige YBX1 Proteine) as promising therapeutic target for NSCLC treatments.

Pig (Porcine) Nanog Homeobox (NANOG) Interaktionspartner

  1. Activin A (zeige INHBA Proteine) and overexpression of SMAD2 (zeige SMAD2 Proteine)/3 significantly promoted expressions of porcine NANOG and OCT4 (zeige POU5F1 Proteine),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog/OCT4 (zeige POU5F1 Proteine) expression.

  2. the functional porcine NANOG that is different in chromosomal structure from mouse and human genes is a single exon gene and encodes the functional NANOG protein.

  3. Results demonstrate that Nanog could interact with and activate other pluripotent genes both in porcine fetal fibroblasts and embryos.

  4. Localisation of NANOG, OCT4 (zeige POU5F1 Proteine), and E-CADHERIN (zeige CDH1 Proteine) in porcine pre- and peri (zeige PLIN1 Proteine)-implantation embryos.

Cow (Bovine) Nanog Homeobox (NANOG) Interaktionspartner

  1. analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos

  2. Nanog displayed relatively the same methylation levels between sperm and oocytes

  3. Noggin, a cytokine inhibiting the BMP4 pathway, successfully upregulated the relative expression of NANOG mRNA in the ICM explants with respect to controls.

Nanog Homeobox (NANOG) Protein Überblick

Protein Überblick

Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT-3'. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity).

Alternative names and synonyms associated with Nanog Homeobox (NANOG)

  • Nanog homeobox (Nanog)
  • Nanog homeobox (NANOG)
  • 2410002E02Rik Protein
  • ecat4 Protein
  • ENK Protein

Bezeichner auf Proteinebene für Nanog Homeobox Proteine (NANOG)

ES cell-associated protein 4 , early embryo specific expression NK family , early embryo specific expression NK-type homeobox protein , homeobox protein NANOG , homeobox transcription factor Nanog , hNanog , homeobox transcription factor Nanog-delta 48 , homeodomain transcription factor Nanog , homeobox transcription factor NANOG

71950 Mus musculus
79923 Homo sapiens
100170132 Sus scrofa
538951 Bos taurus
486701 Canis lupus familiaris
100860956 Capra hircus
414065 Rattus norvegicus
748301 Pan troglodytes
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