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Members of the SIN3A/HDAC2 corepressor complex are enriched in an extended NANOG interactome.
Functional studies revealed that knockdown of Nanog eliminated the mESC self-renewal-promoting ability of Sp5. Finally, we demonstrated that the self-renewal-promoting function of Sp5 was largely dependent on its zinc finger domains
Otx2 (zeige OTX2 Proteine)-mediated Nanog regulation contributes to the integrity of the embryonic stem cell state and cell lineage specification in preimplantation development (zeige MTA2 Proteine).
Maintenance of pluripotency is regulated by a network of transcription factors coordinated by Oct4 (zeige POU5F1 Proteine), Sox2 (zeige SOX2 Proteine), and Nanog; Trim24 (zeige TRIM24 Proteine) significantly improved efficiency of cellular reprogramming, demonstrating its direct functionality in establishing pluripotency.
studies highlight a new hypoxia-induced pathway in which NANOG activates BNIP3L (zeige BNIP3L Proteine) expression, contributing to autophagy induction in hypoxic tumor cells and their resistance to killing by CTL
Genetic reporters can compromise the behavior of important pluripotency-sustaining positive feedback loops, and induce a bifurcation in the underlying dynamics that gives rise to heterogeneous Nanog expression patterns in reporter cell lines that are not representative of the wild-type; findings help explain the range of published observations of Nanog variability and highlight the problem of measurement in live cells.
Here the authors couple mutagenesis with functional and dimerization assays to show that the number of tryptophans within the tryptophan repeat is linked to the strength of homodimerization, Sox2 (zeige SOX2 Proteine) heterodimerization and self-renewal activity.
In mouse model of acute uterine injury, Nanog homebox (NANOG) express (zeige SRY Proteine)ion reached (zeige SOX2 Proteine) a peak at 6 h, while sex-determining (zeige POU5F1 Proteine) region Y-box2 (SOX2) and octamer-binding protein 4 (OCT4) peaked later at 12 h after lipopolysaccharide (LPS) treatment.
NANOG as a key regulator connecting the pluripotency network with constitutive heterochromatin organization in mouse embryonic stem cells.
Data indicate that Nanog homeobox protein (zeige HOXA1 Proteine) is important for the effects of reprogramming media.
RNAi-mediated silencing of NANOG in SKOV-3 reversed the expression of mesenchymal cell markers and restored expression of E-cadherin. Susceptibility to cisplatin increased in SKOV-3 cells on down-regulating NANOG and reversible results were obtained in Moody cells post-overexpression of NANOG.
NANOG enabled reactivation of the ROCK and Transforming Growth Factor (TGF)-beta pathways-both of which were impaired in senescent cells-leading to ACTIN polymerization, MRTF-A translocation into the nucleus and serum response factor (SRF)-dependent myogenic gene expression.
High NANOG expression is associated with brain neoplasms.
Super-enhancers at the Nanog locus differentially regulate neighboring pluripotency-associated genes, in particular, DPPA3 (zeige DPPA3 Proteine).
our data reveal that SATB2 in alveolar bone mesenchymal stem cells (AB-BMSCs) associates with their age-related properties, and prevents AB-BMSCs senescence via maintaining Nanog expression.
High NANOG expression is associated with Multidrug Resistance in breast and cervical cancer.
miR-612 has a suppressive role on hepatocellular carcinoma cell stemness via Sp1/Nanog signaling pathway.
These data reveal an overexpression of NANOG and other markers of pluripotency and stemness in meningiomas.
The NANOG deficiency affected multiple genes, particularly, supressed drug-resistance via down-regulated ABCG2 in Eca109 cells, and caused G1 arrest by down-regulated cyclin D1 (CCND1 (zeige CCND1 Proteine)) expression.
Endogenous Plastic Somatic (ePS) cells in a latent state, i.e. lacking SOX2 (zeige SOX2 Proteine), OCT3/4 (zeige POU5F1 Proteine) and NANOG (SON) expression, in non-diseased breast specimens through immunohistochemical analysis of previously identified ePS-specific biomarkers (CD73(+), EpCAM (zeige EPCAM Proteine)(+) and CD90 (zeige THY1 Proteine)(-)).
analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos
Nanog displayed relatively the same methylation levels between sperm and oocytes
Noggin, a cytokine inhibiting the BMP4 pathway, successfully upregulated the relative expression of NANOG mRNA in the ICM explants with respect to controls.
Activin A (zeige INHBA Proteine) and overexpression of SMAD2 (zeige SMAD2 Proteine)/3 significantly promoted expressions of porcine NANOG and OCT4 (zeige POU5F1 Proteine),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog/OCT4 (zeige POU5F1 Proteine) expression.
the functional porcine NANOG that is different in chromosomal structure from mouse and human genes is a single exon gene and encodes the functional NANOG protein.
Results demonstrate that Nanog could interact with and activate other pluripotent genes both in porcine fetal fibroblasts and embryos.
Localisation of NANOG, OCT4 (zeige POU5F1 Proteine), and E-CADHERIN (zeige CDH1 Proteine) in porcine pre- and peri (zeige PLIN1 Proteine)-implantation embryos.
NANOG and SOX2 (zeige SOX2 Proteine) expression inversely correlated with the DNA methylation (zeige HELLS Proteine) pattern in the promoter region
report the isolation of complete coding regions of rabbit SOX2, KLF4, C-MYC and NANOG, which encode transcription factors that play crucial regulatory roles during early mammalian embryonic development
The authors show, at single-cell resolution in vivo, that Pou5f3 complexes with Nanog to pattern mesendoderm differentiation at the blastula stage.
Nanog has a role in supressing cell migration.
maternal Nanog, Pou5f1 (zeige POU5F1 Proteine) and SoxB1 are required to initiate the zygotic developmental program and induce clearance of the maternal program by activating miR (zeige MYLIP Proteine)-430 expression
Depletion of Nanog in zebrafish cannot be rescued by ectopic expression of Xvent, and Xvent depletion in Xenopus cannot be overcome by ectopic expression of zebrafish Nanog.
This study identified a Nanog-like-Mxtx2-Nodal pathway and establishes a role for Nanog-like in regulating the formation of the extraembryonic tissue required for endoderm induction.
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT-3'. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity).
ES cell-associated protein 4
, early embryo specific expression NK family
, early embryo specific expression NK-type homeobox protein
, homeobox protein NANOG
, homeobox transcription factor Nanog
, homeobox transcription factor Nanog-delta 48
, homeobox transcription factor NANOG
, Nanog homeobox
, nanog homeobox transcription factor
, homeodomain transcription factor Nanog
, LOW QUALITY PROTEIN: homeobox protein NANOG
, nanog homeobox
, ovary-expressed homeobox protein