LRP1 Proteine (LRP1)

Low Density Lipoprotein Receptor-Related Protein 1 Proteine (LRP1)
Auf finden Sie aktuell 11 Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) Proteine von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen LRP1 Antikörper (165) und LRP1 Kits (33) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 222 LRP1 Produkte verfügbar.
A2mr, AI316852, APOER, APR, CD91, IGFBP3R, Lrp, LRP-1, LRP1A, TGFBR5
alle Proteine anzeigen Gen GeneID UniProt
LRP1 4035 Q07954
LRP1 16971 Q91ZX7
Ratte LRP1 LRP1 299858  

Weitere Synonyme anzeigen

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Am meisten referenzierte LRP1 Proteine

  1. Human LRP1 Protein expressed in Human Cells - ABIN2004497 : Su, Nakada-Tsukui, Tosello-Trampont, Li, Bu, Henson, Ravichandran: Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). in The Journal of biological chemistry 2002 (PubMed)
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Weitere Proteine zu LRP1 Interaktionspartnern

Human Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) Interaktionspartner

  1. Poor LRP1 expression in T cells depends on shedding. Integrin ligands and CXCL12 (zeige CXCL12 Proteine) antagonize shedding through a TSP-1 (zeige THBS1 Proteine)-dependent pathway and ligation of CD28 (zeige CD28 Proteine) antagonizes shedding independent of TSP-1 (zeige THBS1 Proteine).

  2. Altered Met receptor phosphorylation and LRP1-mediated uptake in cells lacking carbohydrate-dependent lysosomal targeting

  3. LRP1 single-nucleotide polymorphism is associated with migraine.

  4. Electrostatic potential calculations suggested a competition between negatively charged GAGs and highly negatively charged complement-like domains of LRP-1 for the binding to a positively charged area of TIMP-3 (zeige TIMP3 Proteine) as an underlying mechanism.

  5. findings revealed a pH-dependent release of the ligand associated with a conformational change of the receptor. In summary, this investigation of the complete LRP1 ectodomain significantly advances our understanding of this important receptor and provides the basis for further elucidating the mechanism of action of LRP1 in a whole and integrated system.

  6. although fVIII (zeige F8 Proteine) bound avidly to soluble forms of clusters II and IV from LRP1, only soluble cluster IV competed with the binding of fVIII (zeige F8 Proteine) to full-length LRP1, revealing that cluster IV represents the major fVIII (zeige F8 Proteine) binding site in LRP1.

  7. LRP1 protein expression in human abdominal aortic aneurysm tissues may be down-regulated by miR (zeige MLXIP Proteine)-205 through translational inhibition, resulting in a reduced clearance of pericellular MMP-9 (zeige MMP9 Proteine), promoting aneurysm formation.

  8. data also reveal that D1D2 is able to bind to a second distinct site on LRP1 to form a monovalent complex. The studies confirm the canonical model for ligand recognition by this class of receptors, which is initiated by pairs of lysine residues that dock into acidic pockets on the receptor

  9. results indicate that genetic variations in LRP1 and ULK4 contribute to risk for presenting with an acute aortic dissection

  10. Considering that LRP-1, by mediating the clearance of matrix metalloproteinases, is involved in the regulation of extracellular matrix remodeling and cell migration, we conclude that a decreased expression of LRP-1 could be involved with the increasing activity of MMPs shown in cancers.

Mouse (Murine) Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) Interaktionspartner

  1. ApoC-III (zeige APOC3 Proteine) inhibits turnover of TG-rich lipoproteins primarily through a hepatic clearance mechanism mediated by the LDLR (zeige LDLR Proteine)/LRP1 axis

  2. These results provide evidence supporting a key role for the p38 MAPK (zeige MAPK14 Proteine) signaling pathway which is involved in the regulation of Abeta1-42 internalization in the parietal cortex and hippocampus of mouse through LRP1 in vivo.

  3. BMPER (zeige BMPER Proteine)/low-density lipoprotein receptor-related protein 1 axis plays a pivotal role in pulmonary inflammatory response.

  4. report that LRP1 expression is rapidly lost as oligodendrocyte progenitor cells differentiate, and is absent from all oligodendrocytes, including newborn oligodendrocytes

  5. Results show evidence of low-density lipoprotein receptor-related protein 1 ( (LRP1) expression and activity modulation by Intravenous immunoglobulin (IVIg), and support the role of LRP1 as a partner of IVIg in the execution of its neuroprotective effects.

  6. LRP1 deficiency in mature adipocytes promotes diet-induced inflammation and atherosclerosis.

  7. TNF-alpha (zeige TNF Proteine) blockade exerts antiatherosclerotic effects that are dependent on the presence of macrophage LRP1.

  8. these results documented that LRP1 deficiency in hepatocytes promotes lipid accumulation and lipotoxicity through lysosomal-mitochondrial permeabilization and ER stress that ultimately result in cell death. Hence, LRP1 dysfunction may be a major risk factor in fatty liver disease progression.

  9. A critical role was determined for astrocytic LRP1 in brain for clearing amyloid-beta accumulation.

  10. Findings provide evidence for a central role of LRP1 in overall energy homeostasis, and specifically liver glucose and fatty acid metabolism. Its somatic inactivation in the liver predisposes to diet-induced insulin (zeige INS Proteine) resistance with dyslipidemia and non-alcoholic hepatic steatosis.

LRP1 Protein Überblick

Protein Überblick

The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.

Alternative names and synonyms associated with LRP1

  • low density lipoprotein receptor-related protein 1 (LRP1)
  • low density lipoprotein receptor-related protein 1 (Lrp1)
  • A2mr Protein
  • AI316852 Protein
  • APOER Protein
  • APR Protein
  • CD91 Protein
  • IGFBP3R Protein
  • Lrp Protein
  • LRP-1 Protein
  • LRP1A Protein
  • TGFBR5 Protein

Bezeichner auf Proteinebene für LRP1

low density lipoprotein receptor-related protein 1 , prolow-density lipoprotein receptor-related protein 1-like , LRP-1 , TbetaR-V/LRP-1/IGFBP-3 receptor , alpha-2-macroglobulin receptor , apolipoprotein E receptor , prolow-density lipoprotein receptor-related protein 1 , type V tgf-beta receptor , alpha 2-macroglobulin receptor , lipoprotein receptor-related protein , low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) , low-density lipoprotein receptor-related protein/alpha-2 macroglobulin receptor , low-density lipoprotein receptor-related protein 1

100414789 Callithrix jacchus
4035 Homo sapiens
16971 Mus musculus
299858 Rattus norvegicus
100009547 Oryctolagus cuniculus
100726418 Cavia porcellus
100627964 Sus scrofa
481124 Canis lupus familiaris
533894 Bos taurus
396170 Gallus gallus
101120656 Ovis aries
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